A5100670549- Bryophyte Studies and Records
- Autophagy in Disease and Therapy
- Microbial Natural Products and Biosynthesis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Endoplasmic Reticulum Stress and Disease
- Prostate Cancer Treatment and Research
- Lichen and fungal ecology
- Fungal Biology and Applications
- Pharmacological Effects of Medicinal Plants
- Natural product bioactivities and synthesis
- Botany and Plant Ecology Studies
- Estrogen and related hormone effects
- Ubiquitin and proteasome pathways
- Catalytic C–H Functionalization Methods
- RNA Research and Splicing
- Plant Toxicity and Pharmacological Properties
- Hormonal and reproductive studies
- Drug Transport and Resistance Mechanisms
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Cellular transport and secretion
- Bone Metabolism and Diseases
Shandong University
2015-2025
Zhejiang Ocean University
2025
Hanyang University
2025
China Electronic Information Industry Development
2025
Second Hospital of Shandong University
2018-2024
Huazhong University of Science and Technology
2018-2023
Tongji Hospital
2018-2023
Shaoguan Railway Hospital
2020-2023
John Wiley & Sons (United Kingdom)
2023
University of Oxford
2023
Abstract Ferroptosis suppressor protein 1 (FSP1, also known as AIMF2, AMID or PRG3) is a recently identified glutathione-independent ferroptosis 1–3 , but its underlying structural mechanism remains unknown. Here we report the crystal structures of Gallus gallus FSP1 in substrate-free and ubiquinone-bound forms. The reveal FAD-binding domain NAD(P)H-binding domain, both which are shared with AIF NADH oxidoreductases 4–9 characteristic carboxy-terminal well. We demonstrate that crucial for...
Melatonin is a critical regulator of biological rhythms across organisms, transducing light signals into neuroendocrine that facilitate reproductive regulation in response to environmental cues. However, the precise mechanisms through which melatonin regulates reproduction fish require further investigation. In this study, we employed molecular and organizational techniques examine expression patterns its five receptor subtypes (LcMTNR1A1, LcMTNR1A2, LcMTNR1B1, LcMTNR1B2, LcMTNR1C) various...
Abstract The first one‐pot enantioselective oxidative coupling of cyclic benzylic ethers with aldehydes has been developed. A variety were transformed into the corresponding oxygen heterocycles high enantioselectivity. Mechanistic experiments conducted to determine nature reaction intermediates. application this strategy reactions other nucleophiles besides was also explored.
Betulin and betulinic acid have been widely studied for their anticancer activities. However, further development is limited due to low bioavailability, poor aqueous solubility, intracellular accumulation. In the present study, a triphenylphosphonium cation moiety was linked betulin specifically target them cancer cell mitochondria. Biological characterization established that uptake of mitochondria-targeted compound 1a in mitochondria cells increased compared betulin. The derivatives showed...
Abstract Described is a practical and universal CH functionalization of readily removable N ‐benzyl ‐allyl carbamates, with wide range nucleophiles at ambient temperature promoted by Ph 3 CClO 4 . The metal‐free reaction has an excellent functional‐group tolerance, displays broad scope respect to both ‐carbamates nucleophile partners (a variety organoboranes compounds). synthetic utility in target‐ as well diversity‐oriented syntheses demonstrated.
Combination therapy is frequently used in cancer treatments. Delivery of combined anticancer agents loaded a nanocarrier would be promising option for combination therapy. Here, we designed PEGylated nano-liposomes co-delivery Docetaxel (Doc) and Resveratrol (Res) to evaluate antitumor efficiency the drugs prostate cancer. The average diameter liposomes was 99.67 nm with spheral-like shape. Drug release studies showed that both could synchronously leak from sustained behavior. Cellular...
Mixed lineage kinase domain-like protein (MLKL) serves as a critical mediator in necroptosis, form of regulated cell death linked to various liver diseases. This study aims specifically investigate the role MLKL's adenosine triphosphate (ATP)-binding pocket facilitating necroptosis-independent pathways that may contribute disease progression. By focusing on this mechanism, we seek identify potential therapeutic targets can modulate MLKL activity, offering new strategies for prevention and...
A chemical investigation of the endolichenic fungus Aspergillus versicolor (125a), which was found in lichen Lobaria quercizans, resulted isolation four novel diphenyl ethers, named diorcinols F-H (1-3, resp.) and 3-methoxyviolaceol-II (4), eight new bisabolane sesquiterpenoids, (-)-(R)-cyclo-hydroxysydonic acid (5), (-)-(7S,8R)-8-hydroxysydowic (6), (-)-(7R,10S)-10-hydroxysydowic (7), (-)-(7R,10R)-iso-10-hydroxysydowic (8), (-)-12-acetoxy-1-deoxysydonic (9), (-)-12-acetoxysydonic (10),...
It is generally accepted that the origin of cytotoxicity ent-kaurane diterpenoids due to formation reactive oxygen species (ROS) and α,β-unsaturated carbonyl a pivotal moiety. Herein we demonstrate isolation 32 new 12 known from two Chinese liverworts. These compounds three semisynthesized derivatives were screened against human cancer cell lines. The results revealed their anticancer activities are caused by ROS through Michael modification protein thiols depletion glutathione...
The transactivation function of the human androgen receptor (AR) can be regulated by several coregulators that may either positive or negative. Ubiquitous transcription factor Sp1 not only regulates basal expression AR but also acts as its coregulator. Our previous study has shown quercetin, one main polyphenols, effectively inhibit and AR. present is to address if quercetin affect Sp1's action on activity in prostate adenocarcinoma cell lines, LNCaP PC-3. First, we showed indeed transient...
BACKGROUND Approximately 50% of prostate cancer (PCa) patients in Western countries harbor ERG rearrangement with concurrent overexpression. Overexpression SOX4 has been shown to play important roles multiple cancers including PCa. However, the link between these two critical genetic aberrations was unclear. METHODS Fluorescence situ hybridization and immunohistochemistry were utilized detect expression. Cellular function evaluated by transwell, wound healing assays, cell adhesion assay,...
Background: The prognostic nutritional index (PNI) has been described as a simple risk-stratified tool for several diseases. We explored the predictive role of PNI on coronavirus disease 2019 (COVID-19) severity. Methods: A total 101 patients with COVID-19 were included in this retrospective study from January 2020 to March 2020. They divided into two groups according severity: non-critical ( n = 56) and critical 45). was calculated upon hospital admission: 10 × serum albumin (g/dL) + 0.005...
Abstract Background Could nutritional status serve as prognostic factors for coronavirus disease 2019 (COVID-19)? The present study evaluated the clinical and characteristics of COVID-19 patients explored relationship between risk malnutrition at admission in-hospital mortality. Methods A retrospective, observational was conducted in two hospitals Hubei, China. Confirmed cases were typed mild/moderate, severe, or critically ill. Clinical data death collected. assessed using geriatric index...
Separation of the water-soluble fraction peanut skins led to isolation 8 flavonoids and two novel indole alkaloids. Two new flavonoid glycosides have been identified as isorhamnetin 3-O-[2-O-β-glucopyranosyl-6-O-α-rhamnopyranosyl]-β-glucopyranoside 3′,5,7-trihydroxyisoflavone-4′-methoxy-3′-O-β-glucopyranoside. alkaloids are 2-methoxyl-3-(3-indolyl)-propionic acid 2-hydroxyl-3-[3-(1-N-methyl)-indolyl]-propionic acid. These isolated were evaluated for their free radical scavenging activity...