A5100769234- Extracellular vesicles in disease
- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Traditional Chinese Medicine Studies
- Bone health and treatments
- Nanoplatforms for cancer theranostics
- Bone and Joint Diseases
- 3D Printing in Biomedical Research
- Clinical practice guidelines implementation
- Cell Adhesion Molecules Research
- Bone health and osteoporosis research
- Cancer-related molecular mechanisms research
- Healthcare and Venom Research
- Acupuncture Treatment Research Studies
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Orthopedic Infections and Treatments
- NF-κB Signaling Pathways
- Health and Medical Research Impacts
- Cancer Cells and Metastasis
- Medical Research and Treatments
- Protease and Inhibitor Mechanisms
- Nanoparticle-Based Drug Delivery
- Rheumatoid Arthritis Research and Therapies
Sun Yat-sen University
2024-2025
The Seventh Affiliated Hospital of Sun Yat-sen University
2025
Shanghai University
2021-2024
Zhongshan Hospital
2011-2024
Xi'an Medical University
2024
New York University Shanghai
2024
Xi'an Honghui Hospital
2024
Xi'an Jiaotong University
2024
Changzhi Medical College
2017-2023
Shanghai University of Sport
2022
Abstract 3D‐printed polycaprolactone (PCL) scaffolds have been extensively studied for application in bone tissue engineering. However, PCL‐based with enhanced bioactivity and intelligent delivery capability repair remains challenging. Herein, CuS nanoparticle‐PEG soft hydrogel‐coated 3D hard (denoted as CuS‐PEG‐PCL scaffold) are rationally designed efficient regeneration. nanoparticles cross‐linked PEG hydrogel (CuS‐PEG‐hydrogel) endows the scaffold excellent photothermal properties stable...
Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the mechanism is unclear. We used lymphocyte cytosolic protein 1 (Lcp1) knockout mice suppress osteoclasts in a OA model with anterior cruciate ligament transection (ACLT), Lcp1-/- showed decreased retarded degeneration. For mechanisms, activated induced type-H vessels elevated oxygen concentration, which ubiquitylated...
Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture healing. Macrophages play key role in the process of healing by undergoing polarization into either M1 or M2 subtypes, which respectively exhibit pro-inflammatory anti-inflammatory functions. Therefore, modulation macrophage subtype beneficial for Exosomes perform an important improving osteoimmune microenvironment due their extremely low immunogenicity and high bioactivity. In this study, we extracted...
Drug resistance in cancer remains a major challenge oncology, impeding the effectiveness of various treatment modalities. The nuclear factor-kappa B (NF-κB) signaling pathway has emerged as critical player development drug cells. This comprehensive review explores intricate relationship between NF-κB and cancer. We delve into molecular mechanisms through which activation contributes to against chemotherapeutic agents, targeted therapies, immunotherapies. Additionally, we discuss potential...
Osteoporosis (OP) is a systematic bone disease characterized by low mass and fragile microarchitecture. Conventional treatment for OP has limited efficacy long-term toxicity. Synthetic biology makes bacterial extracellular vesicle (BEVs)-based therapeutic strategies promising alternative the of OP. Here, we constructed recombinant probiotics Escherichia coli Nissle 1917-pET28a-ClyA-BMP-2-CXCR4 (ECN-pClyA-BMP-2-CXCR4), in which BMP-2 CXCR4 were overexpressed fusion with BEVs surface protein...
Abstract In addition to its recognized role in providing structural support, bone plays a crucial maintaining the functionality and balance of various organs by secreting specific cytokines (also known as osteokines). This reciprocal influence extends these modulating homeostasis development, although this aspect has yet be systematically reviewed. review aims elucidate bidirectional crosstalk, with particular focus on osteokines. Additionally, it presents unique compilation evidence...
Osteoarthritis (OA) is the most common type of arthritis with no effective therapy. Subchondral bone and overlying articular cartilage are closely associated function as "osteo-chondral unit" in joint. Abnormal mechanical load leads to activated osteoclast activity increased resorption subchondral bone, which implicated onset OA pathogenesis. Thus, inhibiting activation could prevent onset. Betaine, isolated from Lycii Radicis Cortex (LRC), has been demonstrated exert anti-inflammatory,...
Cartilage defects are usually caused by acute trauma and chronic degeneration. However, it is still a great challenge to improve the repair of articular cartilage due limited self-regeneration capacity such defects. Herein, novel ROS-responsive in situ nanocomposite hydrogel loaded with kartogenin (KGN) bone marrow-derived stem cells (BMSCs) was designed constructed via enzymatic reaction fibrinogen thrombin. Meanwhile, thioketal (TK)-based liposome synthesized load chondrogenesis-inducing...
Abstract Background Osteoporosis is characterized by an imbalance in bone homeostasis, resulting the excessive dissolution of minerals due to acidified microenvironment mediated overactive osteoclasts. Oroxylin A (ORO), a natural flavonoid, has shown potential reversing osteoporosis inhibiting osteoclast-mediated resorption. The limited water solubility and lack targeting specificity hinder effective accumulation within pathological environment osteoporosis. Results Osteoclasts’...
Abstract Organoids have emerged as crucial platforms in tissue engineering and regenerative medicine but confront challenges faithfully mimicking native structures functions. Bioprinting technologies offer a significant advancement, especially when combined with organoid bioinks-engineered formulations designed to encapsulate both the architectural functional elements of specific tissues. This review provides rigorous, focused examination evolution impact bioprinting. It emphasizes role...