A5075884605- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Lubricants and Their Additives
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Veterinary Equine Medical Research
- Connective tissue disorders research
Shanghai University
2023-2024
XinHua Hospital
2023-2024
Shanghai Jiao Tong University
2023-2024
Changhai Hospital
2023
Second Military Medical University
2023
Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the mechanism is unclear. We used lymphocyte cytosolic protein 1 (Lcp1) knockout mice suppress osteoclasts in a OA model with anterior cruciate ligament transection (ACLT), Lcp1-/- showed decreased retarded degeneration. For mechanisms, activated induced type-H vessels elevated oxygen concentration, which ubiquitylated...
Posttraumatic osteoarthritis (PTOA) patients are often diagnosed by X-ray imaging at a middle-late stage when drug interventions less effective. Early PTOA is characterized overexpressed matrix metalloprotease 13 (MMP13). Herein, we constructed an integrated diagnosis and treatment micelle modified with MMP13 enzyme-detachable, cyanine 5 (Cy5)-containing PEG, black hole quencher-3 (BHQ3), cRGD ligands loaded siRNA silencing (siM13), namely ERMs@siM13. ERMs@siM13 could be cleaved in the...