A5100343772- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Advanced MRI Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- Traditional Chinese Medicine Analysis
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Bone health and osteoporosis research
- Phytochemistry and Biological Activities
- Ultrasound Imaging and Elastography
- Bone and Joint Diseases
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Infant Development and Preterm Care
- Respiratory viral infections research
- Cerebral Palsy and Movement Disorders
- Autophagy in Disease and Therapy
- Fungal Biology and Applications
- Parasitic infections in humans and animals
- Kidney Stones and Urolithiasis Treatments
- Congenital Anomalies and Fetal Surgery
Jiangsu University
2015-2025
Institute of Geographic Sciences and Natural Resources Research
2025
Fujian Academy of Agricultural Sciences
2025
Chinese Academy of Sciences
2016-2025
Nanjing University of Chinese Medicine
2015-2025
First Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Qingdao University
2023-2025
Affiliated Hospital of Qingdao University
2023-2025
Nantong University
2024
Shaanxi University of Science and Technology
2023-2024
Posttraumatic osteoarthritis (PTOA) patients are often diagnosed by X-ray imaging at a middle-late stage when drug interventions less effective. Early PTOA is characterized overexpressed matrix metalloprotease 13 (MMP13). Herein, we constructed an integrated diagnosis and treatment micelle modified with MMP13 enzyme-detachable, cyanine 5 (Cy5)-containing PEG, black hole quencher-3 (BHQ3), cRGD ligands loaded siRNA silencing (siM13), namely ERMs@siM13. ERMs@siM13 could be cleaved in the...
Abstract Introduction The aim of this study was to evaluate the early diagnostic, risk stratification and prognostic value neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9) tissue inhibitor metalloproteinases-1 (TIMP-1), compared with procalcitonin (PCT) Mortality in Emergency Department Sepsis (MEDS) score septic patients emergency department (ED). Methods In total, 480 consecutive adult were enrolled study. They fulfilled systemic inflammatory response...
Abstract Paclitaxel, a known TLR4 ligand, leads to activation of TLR4/MyD88-dependent pathway that mediates chemoresistance and tumor progression in epithelial ovarian carcinoma (EOC). Atractylenolide-I (AO-I), novel TLR4-antagonizing agent, inhibits signaling by interfering with the binding LPS or paclitaxel membrane human leukocytes. In this study, AO-I was found attenuate paclitaxel-induced protein expression IL-6, VEGF survivin enhance early apoptosis growth inhibition MyD88 + EOC cells;...
Abstract Background We retrospectively analyzed 26 persistently asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carriers. Methods Epidemiological and clinical characteristics from the patients with positive results for SARS-CoV-2 ribonucleic acid testing were obtained. Results Twenty-two (84.6%) correlated clustering occurrence. The median period contact to diagnosis last nucleic test was 19 (8–24 days) 21.5 days (10–36 days), respectively. negative significantly...
Rationale: Stem cells self-organize to form organoids that generate mini-organs resemble the physiologically-developed ones.The mechanism by which stem acquire initial potential for generating remains elusive.Here we used skin as an example study how mechanical force drives epidermal-dermal interaction potentiates regenerate hair follicles.Methods: Live imaging analysis, single-cell RNA-sequencing and immunofluorescence were analyze contractile of dermal in organoids.Bulk calcium probe...
With the enormous morbidity and mortality caused by respiratory syncytial virus (RSV) infections among infants elderly, vaccines against RSV are in large market demand.We conducted a first-in-human (FIH), randomized, double-blind, placebo-controlled dose escalation study to evaluate safety immunogenicity response of rRSV vaccine (BARS13) healthy adults aged 18-45. A total 60 eligible participants were randomly assigned receive one four levels or vaccination regimens BARS13 placebo at 4:1...
Rationale: An elevated level of plasma LDL (low-density lipoprotein) is an established risk factor for cardiovascular disease. Recently, we reported that the (pro)renin receptor ([P]RR) regulates metabolism in vitro via LDLR (LDL receptor) and SORT1 (sortilin-1), independently renin–angiotensin system. Objectives: To investigate physiological role (P)RR lipid vivo. Methods Results: We used N-acetylgalactosamine modified antisense oligonucleotides to specifically inhibit hepatic expression...
The clearance of activated hepatic stellate cells (HSCs) by apoptosis is critical for the reversibility fibrosis. Mitochondrial homeostasis regulated mitophagy, which an efficient way clearing injured mitochondria that plays important role in apoptosis. However, mitophagy HSCs and fibrosis still unclear. Here, we show enhanced parallel with increased during reversal inhibition suppressed aggravated mice. In contrast, activation induced HSCs. Furthermore, confirmed BCL-B, a member BCL-2...
Diabetes mellitus (DM), an emerging chronic epidemic, contributes to mortality and morbidity around the world. Diabetic cardiac autonomic neuropathy (DCAN) is one of most common complications associated with DM. Previous studies have shown that satellite glial cells (SGCs) in superior cervical ganglia (SCG) play indispensable role DCAN progression. In addition, it has been purinergic neurotransmitters, as well metabotropic GPCRs, are involved pathophysiological process DCAN. Furthermore,...
<abstract abstract-type="Abstract"> <sec> <b>Introduction</b> Varicella outbreaks significantly disrupt schools and other child-centered institutions. This study aimed to identify patterns epidemiological features of varicella in China from 2006 2022. </sec><sec> <b>Methods</b> Data were extracted outbreak reports submitted the Public Health Emergency Reporting Management Information System within specified timeframe. Analytical methods included Spearman correlation tests Mann-Kendall trend...
Objectives: Postresuscitation care bundle treatment after return of spontaneous circulation in patients experiencing in-hospital cardiac arrest can improve patients’ survival and quality life. The aim the study was to evaluate efficacy safety combined therapy Shenfu injection postresuscitation these patients. Design: Prospective, randomized, controlled clinical study. Setting: Fifty hospitals China. Patients: Adult had experienced between 2012 2015. Interventions: Based on standardized...
Mitophagy affects the activation of hepatic stellate cells (HSCs). Mitochondria-targeted ubiquinone (MitoQ) is a mitochondria-targeted antioxidant that reduces production intracellular reactive oxygen species (ROS). However, its relationship with mitophagy remains unclear. This study evaluated during HSC and effects MitoQ on in cell culture an animal model HSCs. We found reduced HSCs alleviated fibrosis. PINK1 (PTEN-induced putative kinase 1) serine/threonine located mitochondria's outer...
Galectin-14 is specifically expressed in placental trophoblasts, and its expression reduced trophoblasts retrieved from the cervix of women destined to develop early pregnancy loss. However, roles galectin-14 regulating pathogenesis complication have never been investigated. In current research, we aimed investigate regulation trophoblasts. Tissues placenta villi were collected. Primary human trophoblast cell line HTR-8/SVneo used. Western blotting RT-PCR used quantify gene expression. The...
Recently, artemisinin and derivatives have been revealed to possess encouraging antitumor activity. Herein, we integrated the advantages of artesunate platinum drugs construct novel PtIV-artesunate dual-action triple-action complexes. Most derivatives, especially 10f, displayed broad-spectrum potent in vitro activities against a number cancer cell lines. Compound 10f antimetastasis anticlonogenic activities, efficiently induced autophagic death apoptosis, arrested cycle at both S G2/M...
A recent genome-wide association study identified two common variants that confer susceptibility to bladder cancer. We hypothesized these are associated with risk of cancer in Chinese populations. genotyped rs9642880 G>T on 8q24 and rs710521 A>G 3q28 a two-stage case–control evaluate the further examined expression MYC . found G>T, but not polymorphism, was an increased Compared GG genotype, GT/TT genotypes were odds ratio 1.65 (95% confidence interval = 1.25–2.17), this more pronounced...
Ultraviolet A (UVA) radiation contributes to skin photoaging. Baicalin, a plant-derived flavonoid, effectively absorbs UV rays and has been shown have anti-oxidant anti-inflammatory properties that may delay the photoaging process. In current study, cultured human fibroblasts were incubated with 50 μg/ml baicalin 24 hours prior 10 J/cm 2 UVA irradiation. order examine efficacy of treatment in delaying UVA-induced photoaging, we investigated aging-related markers, cell cycle changes,...
Abstract Background Site-specific variations are challenges for pooling analyses in multi-center studies. This work aims to propose an inter-site harmonization method based on dual generative adversarial networks (GANs) diffusion tensor imaging (DTI) derived metrics neonatal brains. Results DTI-derived (fractional anisotropy, FA; mean diffusivity, MD) obtained age-matched neonates without magnetic resonance (MRI) abnormalities: 42 from site 1 and 2. Significant differences of FA can be...
ABSTRACT Introduction As a widely used Chinese herbal medicine, Mume Fructus pulp (MFP) has rich nutritional value and biological activity, but its quality control research is relatively scarce. Objectives The objective of the study was to evaluate difference between MFPs from different origins adulterant apricot (APP), identify potential markers. Methods chemical compositions were identified by untargeted metabolomics analysis based on ultra‐performance liquid chromatography‐quadrupole...