A5100353080- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Influenza Virus Research Studies
- Nutrition and Health in Aging
- Smoking Behavior and Cessation
- Metabolism and Genetic Disorders
- Dietary Effects on Health
- Cardiovascular Disease and Adiposity
- Advanced Battery Materials and Technologies
- Substance Abuse Treatment and Outcomes
- Peroxisome Proliferator-Activated Receptors
- Hippo pathway signaling and YAP/TAZ
- Child Nutrition and Water Access
- Obstructive Sleep Apnea Research
- Neuroscience and Neuropharmacology Research
- Child Abuse and Trauma
- Hydrogen's biological and therapeutic effects
- Simulation-Based Education in Healthcare
- Cellular Mechanics and Interactions
- Advanced battery technologies research
- Cancer Cells and Metastasis
- Birth, Development, and Health
- Adipokines, Inflammation, and Metabolic Diseases
Shenzhen Children's Hospital
2021-2025
Hebei Medical University
2023-2025
Peking University
2011-2024
Chongqing University
2024
Peking University First Hospital
2024
Shandong Center for Disease Control and Prevention
2024
Chongqing University of Technology
2023
Hebei University of Chinese Medicine
2022-2023
Wuhan YZY Biopharma (China)
2023
Tianjin Medical University
2023
FK506-binding protein-51 (FKBP51) is a molecular cochaperone recently shown to be positive regulator of peroxisome proliferator-activated receptor (PPAR)γ, the master adipocyte differentiation and function. In cellular models adipogenesis, loss FKBP51 not only reduced PPARγ activity but also lipid accumulation, suggesting that knock-out (KO) mice might have insufficient development adipose tissue storage ability. This model was tested by examining wild-type (WT) FKBP51-KO under regular...
Abstract Background Body roundness index (BRI) is one of the obesity-related anthropometric indices. However, studies on relationship between BRI and diabetes risk limited. The purpose this study was to explore baseline incident type 2 mellitus (T2DM) in Japanese population. Methods A retrospective longitudinal 15,310 participants a physical examination program at Murakami Memorial Hospital Japan from 2004 2015. association levels T2DM analyzed by Cox proportional-hazards regression, smooth...
Rationale: Stem cells self-organize to form organoids that generate mini-organs resemble the physiologically-developed ones.The mechanism by which stem acquire initial potential for generating remains elusive.Here we used skin as an example study how mechanical force drives epidermal-dermal interaction potentiates regenerate hair follicles.Methods: Live imaging analysis, single-cell RNA-sequencing and immunofluorescence were analyze contractile of dermal in organoids.Bulk calcium probe...
Accurate estimation of food portion sizes remains an important challenge in dietary data collection. The present study aimed to develop a atlas with adequate visual reference improve the accuracy surveys China.
Negative emotions and gut microbiota during pregnancy both bear significant public health implications. However, the relationship between them has not been fully elucidated. This study, utilizing data from a cohort, employed metagenomic sequencing to elucidate anxiety, depression, microbiota’s diversity, composition, species, functional pathways. Data 87 subjects, spanning 225 time points across early, mid, late pregnancy, were analyzed. The results revealed that anxiety depression...
A ratiometric fluorescent probe was described for imaging the production of peroxynitrite in cells stimulated by 5-FU.
Prussian blue analogues (PBAs) as a promising high-voltage cathode material for aqueous zinc-ion batteries (ZIBs) are usually subjected to an ephemeral lifespan and low Coulombic efficiency due the irreversible phase change high Zn2+ insertion potential. Besides, Zn dendrites, H2 evolution reaction, corrosion derived from anode interface remain huge challenges. Given this, highly stable zinc hexacyanoferrate (KZnHCF) together with mixed concentrated electrolyte is prepared realize long-life...
BackgroundThe rapid increase in child and adolescent overweight obesity (OAO) China has a significant health economic impact. This study undertook an investment case analysis to evaluate the impacts of OAO potential returns from implementing specific policies interventions.MethodsThe estimates reduction mortality morbidity set evidence-based interventions across between 2025 2092 using deterministic Markov cohort model. Modelled were identified by literature review expert recommendation...
Abstract Background The ketogenic diet (KD) therapy is a primary treatment for drug-resistant epilepsy, and beta-hydroxybutyrate (BHB) the main ketone produced during KD. However, pattern of increase in BHB levels not well understood, reference range need to be defined. aim this study was evaluate first three months, especially one week, after KD initiation, explore physiological BHB. Methods In our study, fasting initiation strategy used majority patients (252/300, 84%) who underwent 24–48...
While video-based instruction has been employed to teach a range of surgical skills, most videos rely on modular demonstrations, which restrict students' comprehension human tissue structures and their control over intricate procedural details. This study described the development, implementation, evaluation, results novel video curriculum based demonstrations combined with animated simulations. Participants were randomly assigned three groups using simple lottery-based randomization method,...
Meal replacement plans are effective tools for weight loss and improvement of various clinical characteristics but not sustainable due to the severe energy restriction. The aim study was evaluate impact meal replacement, specifically 388 kcal in total energy, on body composition metabolic parameters individuals with overweight obesity from a Chinese population. A parallel, randomized controlled trial performed 174 participants (ChiCTR-OOC-17012000). intervention group (<mml:math...
Aim The purpose of this study is to examine the design and implementation a high-fidelity simulation training course for medical nursing collaboration, based on Fink integrated model. Additionally, aims validate teaching effectiveness course. Background Previous empirical studies have highlighted collaborative healthcare education in institutional hospital training. However, development China has been slow develop China. In recent years, Chinese educators researchers shown interest utilizing...
Tuberous sclerosis complex (TSC) is a rare disease with high risk of epilepsy and cognitive impairment in children. Ketogenic diet (KD) therapy has been consistently reported to be beneficial TSC patients. In this study, we aimed investigate the efficacy safety KD treatment drug-resistant children TSC.In multicenter 53 (33 males 20 females) or caused by were retrospectively recruited from 10 hospitals January 1, 2010, December 31, 2020. Intention-to-treat analysis was used evaluate seizure...
Abstract Humans need to obtain nutrients from foods for survival and health. Culture belief play important roles in food selection intake. Throughout human history, dietary factor has been one of the factors inducing causing outbreaks infectious diseases. If unhealthy eating behavior, like raw/undercooked or meat products wild animals, are not abandoned, foodborne diseases will remain an risk epidemics. The misconception culture is that triggers behavior. Therefore, it vital change people’s...
Introduction In recent years, the relationship between circadian rhythm and overweight obesity has attracted attention of many scholars. Methods To evaluate association duration sleep regularity breakfast overweight. A total 1,178 students from Qingdao University were selected by stratified cluster sampling. There 601 males (24.69 ± 0.80 years old) 569 females (24.54 0.70 old). We used body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) to define levels. Chi-square...
Addressing the increasing global health issue of childhood obesity, exacerbated by pervasive food marketing, this study critically evaluated China's marketing policies in comparison with international best practices, aiming to uncover policy content and implementation gaps inform enhancement strategies.
Ageing is associated with generalized slowing of movement. Gait speed an indicator physical performance. The present study aimed to determine whether the gait could replace comprehensive geriatric assessment (CGA) assess status elderly. 531 participants aged 60 or more years were recruited from inpatients and community population in this study. CGA was performed, including sociodemographic information, neuropsychological assessment, nutritional status, social support health assessment....
Objective: To investigate the association between neighborhood food environment and body mass index (BMI) among Chinese older adults. Methods: A multi-stage stratified random sampling method was used to recruit participants from 12 communities in Beijing, China, 2019. Participants (n = 1764, 1034 women) this study were adults aged 65 80. We collected participants’ basic information, measured their height weight, calculated BMI. Neighborhood environments by density of proximity different...
To evaluate the retention rate, efficacy, and safety of ketogenic diet therapy for drug-resistant epilepsy in children compare results with those a previous cohort at our institution.A total 634 were included this retrospective study. Patients categorized into two groups. The was as control group 317 assessed between 2004 2011, whereas current 2015 2019. provided care usual, additionally adopted goal long-term management strategy. Outcomes measured respect to seizure reduction, adverse...