A5100524402- Advanced Photocatalysis Techniques
- Neonatal and fetal brain pathology
- Immune Cell Function and Interaction
- Immune cells in cancer
- PAPR reduction in OFDM
- Advanced Wireless Communication Technologies
- Advanced Wireless Communication Techniques
- Fetal and Pediatric Neurological Disorders
- Immunotherapy and Immune Responses
- Advanced oxidation water treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Optical Wireless Communication Technologies
- Optical Systems and Laser Technology
- Environmental Impact and Sustainability
- Satellite Communication Systems
- Pesticide Exposure and Toxicity
- Power Line Communications and Noise
- Advanced Neuroimaging Techniques and Applications
- Rheumatoid Arthritis Research and Therapies
- Nanomaterials for catalytic reactions
- Infant Development and Preterm Care
- Adversarial Robustness in Machine Learning
- Physical Unclonable Functions (PUFs) and Hardware Security
- Steroid Chemistry and Biochemistry
- Inflammatory Biomarkers in Disease Prognosis
First Affiliated Hospital of Xi'an Jiaotong University
2022-2025
China Pharmaceutical University
2017-2025
Nanyang Technological University
2022-2025
Tongji University
2023-2024
SingHealth
2024
Shanghai Tenth People's Hospital
2023-2024
China Agricultural University
2024
Fuzhou University
2024
Xiamen University
2023
University of Edinburgh
2021-2022
Abstract Background MUC16 (CA125) is a commonly used tumor marker for ovarian cancer screening and reported to be an immunosuppressive factor by acting on the sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) surface of natural killer cells (NK cells), B cells, monocytes. However, role neutrophils in microenvironment remains further explored. Methods The correlation between proportion count peripheral blood serum inflammatory-related factors level patients was constructed based...
Cholesterol plays an important role in maintaining normal physiological function of human body. However, excessive intake will induce a series diseases including cancer. For melanoma, the relationship between hypercholesterolemia and its incidence remains unknown. The cholesterol metabolite 27-hydroxy (27-HC) catalyzed by CYP27A1 has been reported to activate estrogen receptor (ER). As studies have indicated that melanoma expresses ER, we designed experiments explore whether 27-HC could link...
5552 Background: Tumor-infiltrating lymphocytes (TILs) therapy has shown limited success in patients with recurrent ovarian cancer (OC). To improve TIL antitumor activity, we designed glycosylphosphatidylinositol-anchored membrane-bound interleukin-7 (mbIL-7-GPI) to engineer TILs (mbIL-7-TIL) through piggyBac transposon system. This study aimed investigate the safety and efficacy of mbIL-7-TIL OC patients. Methods: is a single-center, investigator-initiated, open-label, single-arm phase 1...
To observe the influence of Xinfeng-capsule (XFC) on abarticular pathologic changes (APCs) and other indices patients with rheumatoid arthritis (RA) explore mechanism action XFC in improving such changes. Three-hundred RA were divided randomly into a treatment group (n=150) control (n=150). A normal (NC) (n=90) was also created. Changes cardiac function, pulmonary anemia platelet parameters measured. Curative effects two groups compared, comparison carried out NC group. In 300 patients, late...
The purpose of this paper is to examine the effect ethical leadership on followers’ subjective and objective career success from a P-E fit perspective. Specifically, mediating effects demands-abilities fit, needs-supplies person-organization in relationship between employee (i.e., satisfaction) mobility promotability) were investigated. We collected two-wave data 160 employees used hierarchical regressions test hypotheses. findings revealed that had positive satisfaction, mobility,...
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Abstract Fluorescence spectroscopy in combination with UV absorption was carried out to investigate the interaction between neodymium–naproxen complex (Nd–NAP) and calf thymus DNA (ctDNA). The experimental results showed that Nd–NAP intercalated ctDNA base pairs. Analysis of fluorescence quenching data by at different temperatures using a Stern–Volmer equation revealed dynamic static occurred simultaneously. binding constants number sites 293 310 K were obtained as 2.904 × 10 4 L mol −1 ,...
Abstract In the present study, an austenitic stainless steel (2Cr17Ni13Mo5) was processed by severe cold rolling (SCR) and subsequent annealing. The grain size severely refined to ∼100 nm after SCR. yield strength (YS) ultimate tensile (UTS) increased 1510.5 MPa 1660.4 MPa, respectively. Nevertheless, ductility decreased significantly. Full recrystallization completed annealing at 800 °C for 1h. However, ultrafine-grained structure maintained with of 780 nm, which is mainly attributed...
Abstract Ovarian cancer lacks effective therapy. Here, we reported three metastatic ovarian patients administrated with a noval TIL therapy, which was designed glycosylphosphatidylinositol-anchored membrane-bound interleukin-7 (mbIL-7-GPI) to engineer TILs (mbIL-7-TIL) through piggyBac transposon system. In advanced patients, infusion of mbIL-7-TILs showed endurable toxicity and prolonged clinical response. After infusion, peripheral peaked around 5-7 days then sharply decreased. We found...
Abstract Background Tumor-infiltrating lymphocyte (TIL) therapy has been restricted by intensive lymphodepletion and high-dose intravenous interleukin-2 (IL-2) administration. To address these limitations, we conducted preclinical clinical studies to evaluate the safety, antitumor activity, pharmacokinetics of an innovative modified regimen in patients with advanced gynecologic cancer. Methods Patient-derived xenografts (PDX) were established from a local recurrent cervical cancer patient....
In this paper, we propose a novel low complexity time domain (TD) oversampling receiver framework under affine frequency division multiplexing (AFDM) waveforms for joint channel estimation and data detection (JCEDD). Leveraging generalized doubly-dispersive model, first derive the input-output (I/O) relationship arbitrary when oversampled in TD present I/O AFDM as an example. Subsequently, utilizing multiple sample streams created via procedure, use parametric bilinear Gaussian belief...
We present a case study that introduces systematic framework for designing an automated guided vehicle (AGV) order fulfillment system. The multi-stage integrated discrete event simulation (DES), super-efficiency data envelopment analysis (S-DEA) model, and Design of Experiments (DOE) methodologies the design AGV system in existing large-scale surgical complex within comprehensive hospital Singapore. Performance metrics derived from this model were consolidated into single relative efficiency...