A5100378189- Cancer-related molecular mechanisms research
- Trace Elements in Health
- Bone Metabolism and Diseases
- Machine Learning in Bioinformatics
- Bone health and treatments
- Circular RNAs in diseases
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Drug-Induced Hepatotoxicity and Protection
- Osteoarthritis Treatment and Mechanisms
- Diet and metabolism studies
- Aluminum toxicity and tolerance in plants and animals
- Pluripotent Stem Cells Research
- Heat shock proteins research
- NF-κB Signaling Pathways
- Genomics and Phylogenetic Studies
- Mesenchymal stem cell research
- Bone and Joint Diseases
- FOXO transcription factor regulation
- Alcohol Consumption and Health Effects
- Cancer Cells and Metastasis
- vaccines and immunoinformatics approaches
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Inflammation biomarkers and pathways
Zhongshan Hospital
2024
Ningxia Medical University General Hospital
2022-2024
Ningxia Medical University
2022-2024
University of Washington
2024
Shanghai University
2009-2023
Chinese People's Liberation Army
2023
Peking University
2023
Changhai Hospital
2019-2021
Second Military Medical University
2019-2021
Heilongjiang Bayi Agricultural University
2020
Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the mechanism is unclear. We used lymphocyte cytosolic protein 1 (Lcp1) knockout mice suppress osteoclasts in a OA model with anterior cruciate ligament transection (ACLT), Lcp1-/- showed decreased retarded degeneration. For mechanisms, activated induced type-H vessels elevated oxygen concentration, which ubiquitylated...
The mechanisms of metallothionein prevention diabetic cardiomyopathy are largely unknown. present study was performed to test whether inhibition nitrosative damage is involved in cardiomyopathy. Cardiac-specific metallothionein-overexpressing transgenic (MT-TG) mice and wild-type littermate controls were treated with streptozotocin (STZ) by a single intraperitoneal injection, both developed diabetes. However, the development cardiomyopathy, revealed histopathological ultrastructural...
The actin-bundling protein L-plastin (LPL) mediates the resorption activity of osteoclasts, but its therapeutic potential in pathological bone loss remains unexplored. Here, we report that LPL knockout mice show increased mass and cortical thickness with more mononuclear tartrate-resistant acid phosphatase-positive cells, osteoblasts, CD31hiEmcnhi endothelial vessels, fewer multinuclear osteoclasts marrow periosteum. deletion impeded preosteoclasts fusion by inhibiting filopodia formation...
Acute ethanol exposure causes liver injury in experimental animals, and accumulating evidence suggests that a major responsible factor for the pathogenesis is endotoxemia, which results from bacterial endotoxin leakage small intestine due to increased intestinal permeability under alcohol challenge. The purpose of this study was examine whether zinc pretreatment would inhibit acute ethanol-induced through prevention changes. Male 129 SvPCJ mice were treated with three intragastric doses...
The differentiation of pluripotent stem cells (PSCs) into diverse functional cell types provides a promising solution to support drug discovery, disease modeling, and regenerative medicine. However, is currently limited by the substantial line-to-line batch-to-batch variabilities, which severely impede progress scientific research manufacturing products. For instance, PSC-to-cardiomyocyte (CM) vulnerable inappropriate doses CHIR99021 (CHIR) that are applied in initial stage mesoderm...
Abstract Bone homeostasis is delicately orchestrated by osteoblasts and osteoclasts. Various pathological bone loss situations result from the overactivated osteoclastogenesis. Receptor activator of nuclear factor κB ligand (RANKL)‐activated NF‐κB MAPK pathways vital for Here, we first time explored effects l ‐tetrahydropalmatine ( ‐THP), an active alkaloid derived corydalis, on formation function osteoclasts in vitro vivo. In RAW264.7 cells marrow monocytes (BMMCs), ‐THP inhibited...
In this paper we present XSW, a new parallel Smith-Waterman algorithm for searching protein sequence databases on the Xeon Phi coprocessor. order to make full use of compute power many-core hardware, have used two-level parallelization scheme: thread level coarse-grained and VPU fine-grained parallelism implement our algorithm. At level, XSW employs multi-threading SIMD parallelism. Knights Corner instructions gain more data We also reorganized database made shuffling operations achieve...
Background: The dysregulation of microRNA (miRNAs) is broadly participated in cancer progression, resulting sustained cell proliferation by directly targeting various targets. This study investigated the expression miR-582 GC and its association with liver metastasis. Methods: Firstly, differentially expressed miRNAs gastric (GC) tissues were predicted microarray. Then, relationship between clinical characteristics patients was analyzed. By silencing cells, change malignant biological...
Direct cardiac reprogramming to induce cardiomyocyte-like cells, e.g., by GMT (Gata4, Mef2c and Tbx5), is a promising route for regenerating damaged heart in vivo disease modeling vitro. Supplementation with additional factors chemical agents can enhance efficiency but raises concerns regarding selectivity fibroblasts complicates delivery situ reprogramming. Here, we screened 2000 chemicals known biological activities found that combination of 2C (SB431542 Baricitinib) significantly enhances...
Age-related osteoporosis is characterized by an imbalance between osteogenic and adipogenic differentiation in bone mesenchymal stem cells (BMSCs). Forkhead box O 3 (FoxO3) transcription factor involved lifespan cell differentiation. In this study, we explore whether FoxO3 regulates age-related loss marrow fat accumulation. The expression levels of BMSCs during aging were detected vivo vitro. To the role differentiation, primary isolated from young aged mice. was modulated adenoviral vector...
The first step in membrane protein type prediction is how to represent the sample of a protein. In this work, can be represented by high-dimension feature vector using DC (Dipeptide Composition) method. This extremely high dimensionality data may increase computing time and classifier complexity. Thus, linear reduction algorithm NPE (Neighborhood Preserving Embedding) introduced extract indispensable features from high-dimensional space. Based on reduced low-dimensional features, K-NN...