A5101671485- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Adrenal Hormones and Disorders
- Diabetes and associated disorders
- Thyroid Disorders and Treatments
- Diabetes Management and Research
- Neuroendocrine Tumor Research Advances
- Metabolism, Diabetes, and Cancer
- Folate and B Vitamins Research
- Thyroid and Parathyroid Surgery
- Cancer Risks and Factors
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Lipid metabolism and disorders
- Medical Research and Treatments
- Reproductive System and Pregnancy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Elbow and Forearm Trauma Treatment
- Erythrocyte Function and Pathophysiology
- Cancer, Lipids, and Metabolism
- Diabetes Treatment and Management
Chinese PLA General Hospital
2015-2024
Hainan General Hospital
2020-2024
Chinese People's Liberation Army
2010-2022
Hainan Branch of People's Liberation Army General Hospital
2021-2022
North Sichuan Medical University
2019
Zhongshan Hospital
2019
Beijing Haidian Hospital
2015
Creative Commons
2015
Fundación Juan March
2015
People's Liberation Army No. 150 Hospital
2010
Objective Pituitary stalk interruption syndrome (PSIS) is characterized by the absence of pituitary stalk, hypoplasia, and ectopic posterior pituitary. Due to rarity PSIS, clinical data are limited, especially in Chinese people. Herein, we analyzed characteristics patients diagnosed with PSIS from our center over 10 years. Patients Methods We retrospectively manifestations laboratory MRI findings 55 PSIS. Results Of 48 (87.3%) were male. The average age was 19.7±6.7 years there no familial...
Abstract Background There are large regional variations in the prevalence and mortality of cardiovascular disease general populations China. It remains uncertain whether type 2 diabetes mellitus (T2DM) varies by region Methods We analyzed data 219,522 Chinese patients with T2DM retrieved from China National HbA1c Surveillance System 2012. used population distribution 2010 to standardize coronary heart (CHD), stroke, composite both 30 provinces seven geological regions. Multivariable logistic...
Abstract We aimed to investigate the association between excess body mass index (BMI) and papillary thyroid cancer (PTC) in an operative population, impact of higher BMI on clinicopathological aggressiveness PTC. Charts 10,844 consecutive patients with nodules undergoing partial or total thyroidectomy 1993 2015 were reviewed. Patients diagnosed PTC stratified 4 groups: < 18.5 (underweight), ≤ 24 (normal-weight), 28 (overweight) ≥ 28(obese). The impacts high prevalence parameters...
Objectives This study aims to summarise the features and trends of thyroid carcinoma in past two decades China. Design, setting participants Clinical data obtained from 10 798 patients treated by thyroidectomy 1994 2015 at Department General Surgery People’s Liberation Army Hospital, Beijing, China were retrospectively analysed. Outcome measures Incidence histopathological cancer compared risk factors for local lymph node metastasis Results Our indicated a significant increase detection...
Given that mutations related to maturity-onset diabetes of the young (MODY) are rarely found in Chinese populations, we aim characterize mutation spectrum MODY pedigrees.Maturity-onset candidate gene- or exome-targeted capture sequencing was carried out 76 probands from unrelated families fulfilling clinical diagnostic criteria for MODY. MAF <0.01 GnomAD ExAC database used filter significant variants. Sanger then validate findings. Function prediction by SIFT, PolyPhen-2 and PROVEAN CADD...
SUMMARY While rabies is a significant public health concern in China, the epidemiology of animal north and northwest border provinces remains unknown. From February 2013 to March 2014, seven outbreaks domestic caused by wild carnivores Xinjiang (XJ) Inner Mongolia (IM) Autonomous Regions, China were reported diagnosed brain samples infected animals fluorescent antibody test (FAT) RT–PCR. Ten field viruses obtained. Sequence comparison phylogenetic analysis based on complete N gene (1353 bp)...
Aim . To investigate the clinical and endocrinological characteristics of patients with adrenal incidentaloma (AI). Materials Methods This retrospective study enrolled 1941 AI hospitalized at Department Endocrinology, Chinese PLA General Hospital, Beijing, China, between January 1997 December 2016. The patient gender, age visits, imaging features, functional status, histological results were analyzed. Results Of patients, 984 (50.70%) men. median was 52 years (interquartile range: 44–69...
The study aimed to investigate the gender-related differences of disease onset, age distribution, blood type, clinical characteristics, and malignant behaviors differentiated thyroid carcinoma (DTC) in Chinese patients. A total 7385 consecutive cancer patients who underwent thyroidectomy were retrospectively reviewed. 4087 (55.3%) diagnosed as benign other (3298, 44.7%) malignant. DTC accounted for 97.6% tumor. More single nodules turned out be male compared multiple (46.9% vs. 40.4%, P =...
The Clonal Selection Algorithm (CSA) is employed by the natural immune system to define basic features of an response antigenic stimulus. In response, according Burnet's clonal selection principle, antigen imposes a selective pressure on antibody population allowing only those cells which specifically recognize be selected for proliferation and differentiation. However ongoing investigations indicate that receptor editing, refers process whereby engagement leads secondary somatic gene...
Recurrent autoimmune hypophysitis is a rare endocrine disease involving lymphocytic infiltration and chronic pituitary inflammation. It even more than primary hypophysitis. The objective of the study was to evaluate efficacy glucocorticoid treatment combined with azathioprine for treating three cases recurrent encountered within two-year period. clinical features follow-up data these were analyzed, including results glucocorticoids azathioprine. All patients female presented following...
Abstract Hepatitis B virus (HBV) infection is a major public health problem worldwide. The mechanism of susceptibility to chronic persistent HBV not well clarified, while the outcome mainly depends on host immune response. Human leukocyte antigen (HLA) class II molecule an integral component response which majority genetic studies have concentrated. Many different HLA alleles been demonstrated play roles in infection. In this study, association between and HLA‐DRB1 Han individuals...
It has been suggested that anti-thyroglobulin antibody (TgAb) are more common among papillary thyroid cancer (PTC). This study investigated the correlation between TgAb expression level and PTC in Chinese patients 2011-2015 a retrospective study. Thyroid goiter who have undergone thyroidectomy received confirmed pathological diagnosis were enrolled into this Demographic data, clinical characteristics preoperative thyroglobulin collected from each patient. Based on test, divided negative...
Analyze the clinical applicability of glucose metabolism indexes and continuous monitoring data on qualitative diagnosis insulinoma.Involve 22 patients with insulinoma (insulinoma group), 11 hypoglycemia (hypoglycemia group) 31 people normal tolerance (control group). HbA1c, fasting blood (FBG), insulin (FINS) C-peptide (FCP) was tested. Using CGMS to monitor for three consecutive days selecting 24 h thereof, figuring out, aid EasyGV Version 9.0, mean (MG), standard deviation (SD) glucose,...
Thyroid nodules are very common. Ultrasound (US) and fine needle aspiration (FNA) both integral in cancer screening. This study investigated the concordance between thyroid nodule sizes measured by US gross pathologic examination their relationship with malignancy.A retrospective design was used to select consecutive patients proven carcinoma of thyroid. The number maximum diameter nodules, rates types malignancy, as well predictors malignancy were determined.The 10 944 examined had 15 283...
Objective Autoimmune hypothalamitis (AHT) is a rare inflammatory disorder that involves the hypothalamus. It remains unclear whether autoimmune hypophysitis (AH) and AHT represent different diseases or aspects of same disease. Thus, further investigation required. Methods A retrospective review medical pathological records patients from Chinese PLA General Hospital were examined January 1, 2005 to May 2017. Clinical data, treatments, outcomes investigated. Results Five female identified...
Primary adrenal lymphoma (PAL) is a rare form of mass. We summarize our experience in its clinical presentation, biochemical indexes, radiological features, pathological information, therapy regimens, and outcomes.This was an institutional review board-approved retrospective medical records surgical pathology specimens patients with diagnosis PAL at the Chinese People's Liberation Army General Hospital First Affiliate Xiamen University between July 2007 2017.Twenty-six were identified. The...
Primary macronodular adrenal hyperplasia (PMAH), also known in the past as bilateral adrenalhyperplasia or adrenocorticotropin (ACTH)-independent hyperplasia, is a rare type of Cushing's syndrome (CS) and associated with bilateralenlargement glands. It accounts for <1% all endogenous cases CS. In order toidentify pathogenic mutations causative gene (AIMAH pedigrees, Whole-genome sequencing three patients family I was used to retrieve candidate genes. Meanwhile, identified by Sanger from two...
The diagnosis of malignant thyroid nodules is still a clinical challenge. This study aimed to determine the ultrasonographic characteristics papillary carcinoma. and pathological data 2453 in cohort 1895 Chinese patients who underwent thyroidectomy from January 2010 December 2012 were retrospectively reviewed. Anteroposterior transversal (AP/TR) diameters ≥1, solid structure, infiltrative margins, hypoechoic appearance, microcalcifications more common than benign (P < 0.01). These features...
Background/Aims: Chronic inflammation contributes to the development of type 2 diabetes mellitus by targeting insulin receptor substrate protein-1 (IRS-1) signaling pathway. Previous studies showed that Leukemia related protein 16 (LRP16) reduced stimulated glucose uptake in adipocytes impairing IRS-1 We explored mechanism which LRP16 promotes inflammatory response. Methods: screened induced proteins lipopolysaccharide (LPS)-stimulated response using liquid chromatography-mass spectrometry...
Aim . To investigate incidental adrenal enlargement clinical characteristics and functional status analyze lesion risk factors. Materials Methods This retrospective study included 578 patients with imaging features showing enlargement. Incidental cases (78) were considered eligible. Demographics, diagnosis, features, concomitant diseases analyzed. Results The number of enlargements proportion increased each year. Mean patient age was 50.32 years. Thirty-nine had unilateral on the left side 3...