A5103088494- Thyroid Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Neuroendocrine Tumor Research Advances
- Cancer-related molecular mechanisms research
- Thyroid Disorders and Treatments
- Coronary Interventions and Diagnostics
- Lipoproteins and Cardiovascular Health
- Artificial Intelligence in Healthcare and Education
- Magnesium in Health and Disease
- melanin and skin pigmentation
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- RNA modifications and cancer
- Cardiac electrophysiology and arrhythmias
- Advanced Biosensing Techniques and Applications
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Analysis
- Anodic Oxide Films and Nanostructures
- S100 Proteins and Annexins
- Radiomics and Machine Learning in Medical Imaging
- Phytoestrogen effects and research
- Thyroid and Parathyroid Surgery
Shandong Provincial QianFoShan Hospital
2013-2025
Shandong First Medical University
2020-2025
Beijing Luhe Hospital Affiliated to Capital Medical University
2021-2022
Chinese PLA General Hospital
2017-2022
China Agricultural University
2020-2021
Shandong University
2013-2020
Duke University
2019
BackgroundThe potential mechanisms of microRNA-1 (miR-1) in the electrical remodeling atrial fibrillation remain unclear. The purpose this study was to evaluate effects miR-1 on effective refractory period (AERP) a right tachypacing model and elucidate mechanisms. Methods ResultsQRT-PCR western blot were used detect expression miR-1, KCNE1, KCNB2 genes after 1-week New Zealand white rabbits. AERP measured using programmable multichannel stimulator, induced by burst stimulation vivo. slowly...
Over the past decades, incidence of thyroid cancer (TC) rapidly increased all over world, with papillary (PTC) accounting for vast majority TC cases.It is crucial to investigate novel diagnostic and therapeutic targets PTC explore more detailed molecular mechanisms in carcinogenesis progression PTC.Based on TCGA GEO databases, FAM111B downregulated tissues predicts better prognosis patients.FAM111B suppresses growth, migration, invasion glycolysis both vitro vivo.Furthermore, estrogen...
More people die from melanoma after a stage I diagnosis than IV diagnosis, because the tools available to clinicians do not readily identify which early-stage cancers will be aggressive. Near-infrared pump-probe microscopy detects fundamental differences in melanin structure between benign human moles and also correlates with metastatic potential. However, biological mechanisms of these changes have been difficult quantify, as many different can contribute signal. We use model systems...
Abstract We aimed to investigate the association between excess body mass index (BMI) and papillary thyroid cancer (PTC) in an operative population, impact of higher BMI on clinicopathological aggressiveness PTC. Charts 10,844 consecutive patients with nodules undergoing partial or total thyroidectomy 1993 2015 were reviewed. Patients diagnosed PTC stratified 4 groups: < 18.5 (underweight), ≤ 24 (normal-weight), 28 (overweight) ≥ 28(obese). The impacts high prevalence parameters...
mTOR inhibitors released from drug-eluting stents (DESs) play a critical role in the pathogenesis of in-stent neoatherosclerosis (ISNA), contributing to development late restenosis (ISR). Circular RNAs (circRNAs) are emerging as key regulators various pathophysiological processes, but their involvement ISNA remains unclear. The expression pattern circRNAs human umbilical vein endothelial cells (HUVECs) treated with everolimus (EVL) was analysed using RNA sequencing. levels circRNAs,...
Aminophenols, which are widely used as components of hair dye and medicine, may function environmental endocrine disruptors by regulating the proliferation endocrine-related cancers. Estrogen receptor α (ERα) is a key regulator breast cancer. Recently, it was found that ERα also participate in transformation progression thyroid tumors, but its interaction with aminophenols tumors not clear. In this study, transcription factor activity BHP10-3 cells (a tumor cell line) examined using...
It has been suggested that anti-thyroglobulin antibody (TgAb) are more common among papillary thyroid cancer (PTC). This study investigated the correlation between TgAb expression level and PTC in Chinese patients 2011-2015 a retrospective study. Thyroid goiter who have undergone thyroidectomy received confirmed pathological diagnosis were enrolled into this Demographic data, clinical characteristics preoperative thyroglobulin collected from each patient. Based on test, divided negative...
Background. Previous studies have shown that the ratio of triglyceride to high-density lipoprotein cholesterol level (TG/HDL-C) is a risk factor for type 2 diabetes mellitus (T2DM). The aim this study was investigate nonlinear relationship between TG/HDL-C and incidence T2DM in Chinese population. Methods. We used logistic regression models estimate odds ratios (ORs) 95% confidence intervals (CIs) among 7,791 participants from Risk Evaluation cAncers diabeTic Individuals: lONgitudinal...
Thyroid nodules are very common. Ultrasound (US) and fine needle aspiration (FNA) both integral in cancer screening. This study investigated the concordance between thyroid nodule sizes measured by US gross pathologic examination their relationship with malignancy.A retrospective design was used to select consecutive patients proven carcinoma of thyroid. The number maximum diameter nodules, rates types malignancy, as well predictors malignancy were determined.The 10 944 examined had 15 283...
Abstract Background Patients with normoalbuminuria and a reduced estimated glomerular filtration rate (eGFR) account for considerable proportion of type 2 diabetes patients. The aim this research was to investigate the epidemiological clinical characteristics normoalbuminuric kidney disease in Chinese population. Methods We included 8131 diabetic patients from multicenter prospective study China. Based on eGFR urinary albumin‐to‐creatinine ratio (UACR), participants were stratified into four...
Objective: This retrospective cohort study is to analyze the impacts of CYP2C19 polymorphism and clopidogrel dosing on in-stent restenosis (ISR) after coronary stenting. Methods: Totally, 111 patients were included, who underwent percutaneous intervention (PCI) with drug-eluting stent. Patients received treatment background aspirin, based genotypes: 75 mg once each day for subjects without loss-of-function (LOF) alleles (n=51; EM), (n=27; IM75) or twice (n=33; IM150) one LOF allele. ISR at...
With the rapid development of IoT technology, it is a new trend to combine edge computing with smart medicine in order better develop modern medicine, avoid crisis information "sibling," and meet requirements timeliness computational performance massive data generated by devices. However, somewhat open prone security risks, so privacy protection systems for healthcare receiving increasing attention. The two groups were compared before after treatment blood glucose, lipids, pressure, renal...
Abstract Background Type 2 diabetes mellitus (T2DM) is the most common type of metabolic disorder involving multiple organ systems. Grape has been reported to improve symptoms T2DM, precise mechanism its action unclear. Our study was aimed determine effect and grape pomace extract in T2DM mice induced by high fat diet (HFD). Materials methods Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry were used identify main active compounds T2DM. C57BLK/6J HFD...
Objective To investigate the influence of Chinese guidelines for thyroid nodules and differentiated cancers on diagnosis treatment nodule patients undergoing surgery in PLA General Hospital. Methods A retrospective analysis was conducted data 2 243 inpatients who were with their pathology results 2011(before guideline change, 1 013 patients)and 2013(after 230 patients). The changes baseline characteristics, diagnosis, constituent nodule, distribution benign size compared between 2011...
Objective To investigate the correlation between body mass index(BMI) and occurence of papillary thyroid carcinoma(PTC)among patients with nodules. Methods This cross-sectional study collected data 4 350 nodules who underwent thyroidectomy in our hospital from January 1994 to December 2013. The were divided into normal weight(BMI 18.50~23.9 kg/m2), overweight(BMI 24.0~27.9 obese(BMI≥28.0 kg/m2)groups according BMI, as well benign carcinoma groups based on their pathological finding....
Objective To investigate the trends in clinicopathological characteristics of thyroid cancer patients undergoing surgery from 1994 to 2013. Methods A retrospective analysis was conducted on clinical data inpatients with nodular diasease thyroidectomy pathology results January December 2013. The pathogenic constituent nodule and 3 399 were analyzed. Results (1)Over past 20 years, proportion diagnosed as gradually increased, especially those papillary cancer(PTC). Whereas...
Objective To determine the correlation between papillary thyroid cancer(PTC) malignancy with antibody expression level. Methods In this retrospective study, 4 046 goiter patients complete clinical data who have undergone thyroidectomy were separated into benign nodule (n=1 357) and PTC groups (n=2 689), their preoperative thyroglobulin (TgAb) peroxidase (TPOAb) assessed through analysis. HT was determined based on postoperative histopathology. The collected then evaluated for...
Abstract Hepatocellular carcinoma (HCC), a common malignant tumor, is one of the main causes cancer-related deaths worldwide. Circular RNAs (circRNAs), novel class non-coding RNA, have been reported to be involved in etiology various malignancy. However, functions circRNAs HCC remain unclear. In this study, through mining RNA sequencing databases from GEO datasets and subsequent experimental verification, we identified that hsa_circ_0000384 (circMRPS35) was highly expressed HCC. Knockdown...