A5100730950- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune cells in cancer
- Ovarian cancer diagnosis and treatment
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- IL-33, ST2, and ILC Pathways
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- CAR-T cell therapy research
- Inflammatory Biomarkers in Disease Prognosis
- Glioma Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Epigenetics and DNA Methylation
- Intraocular Surgery and Lenses
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Liver Disease and Transplantation
- Uterine Myomas and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
Zunyi Medical University
2018-2025
Henan Cancer Hospital
2020-2025
Zhengzhou University
2020-2025
Second Affiliated Hospital of Zhejiang University
2016-2024
Zhejiang University
2008-2024
Gansu University of Traditional Chinese Medicine
2024
Fudan University Shanghai Cancer Center
2019-2022
Peking University
2022
National Clinical Research Center for Digestive Diseases
2022
National Medical Products Administration
2022
T cell immunoglobulin and ITIM domain (TIGIT) CD226 emerge as a novel cosignaling pathway in which TIGIT serve costimulatory coinhibitory receptors, respectively, for the ligands CD155 CD112. In this study, we describe CD112R, member of poliovirus receptor–like proteins, new receptor human cells. CD112R is preferentially expressed on cells inhibits receptor–mediated signals. We further identify that CD112, widely antigen-presenting tumor cells, ligand with high affinity. competes to bind...
Abstract Background Tumor microenvironment (TME) is a complex environment containing tumor cells, tumor-associated macrophages (TAMs), interstitial and non-cellular components. Epithelial–mesenchymal transition (EMT), as major actor in cancer tumorigenicity metastasis, was involved the interaction between TAMs cells. However, potential mechanisms of EMT how EMT-programmed cells affect M2-like still need further exploration. Methods An integrated analysis nine CRC miRNA expression datasets...
Abstract Background Tumor-associated macrophages (TAMs) in the tumor microenvironment influence initiation, invasion and metastasis. Several studies have shown that Wnt5a is mainly expressed stroma, especially TAMs. However, whether regulates polarization biological function of TAMs colorectal cancer (CRC) incompletely understood. Methods Immunofluorescence staining was performed to detect CD68 expression tissues from patients (63 CRC specimens VS 20 normal tissues). RT-qPCR, flow cytometry,...
Background: The interaction and crosstalk between tumor-associated macrophages (TAMs) epithelial-mesenchymal transition (EMT) has been demonstrated to play a critical role in the progression metastasis of multiple cancers. However, roles M2-polarized TAMs different tumor location EMT prognosis colorectal cancer (CRC) have not elucidated. Therefore, present study was designed set up reliable ratio CD163+/CD68+ assess infiltration center (TC) invasive front (TF) further evaluate their...
Background: M2 macrophages are crucial components of tumor microenvironment that frequently associated with the resistance therapeutic treatments in human cancers, but their role chemosensitivity colorectal cancer (CRC) to 5-fluorouracil (5-FU) is still obscure. Methods: In our study, we clarified biological functions and mechanism on CRC cells 5-FU. Then, analyzed correlation between CCL22 CD68+ CD163+ tumor-associated (TAMs), further elucidated prognostic value clinical samples. Results:...
Pretreatment nutritional and immunological statuses play an indispensable role in predicting the outcome of patients with various types malignancies. The purpose this study is to evaluate predictive value albumin/globulin ratio (AGR) overall survival (OS) recurrence hepatocellular carcinoma (HCC) following radical hepatic carcinectomy.This retrospective included a total 172 HCC complete medical follow-up information between 2002 2012. AGR was calculated according formula: = albumin/globulin....
Aim: The authors studied the role of soluble ST2 (sST2) in COVID-19 and its relationship with inflammatory status disease severity. Materials & methods: Serum levels sST2 interleukin (IL)-33, C-reactive protein (CRP), serum amyloid (SAA), IL-6 procalcitonin (PCT), T lymphocyte subsets from 80 subjects diagnosed including 36 mild, 41 severe three asymptomatic cases were tested. Results: significantly increased patients, which positively correlated CRP, but negatively CD4+ CD8+ counts....
Opposite roles of circular RNA MM-associated (circ-MYBL2) have been observed in different malignancies, and its role pancreatic adenocarcinoma (PA) is unknown. Our preliminary sequencing data revealed inverse correlation with microRNA-19a (miR-19a). This study was performed to explore the circ-MYBL2 PA crosstalk miR-19a. The accumulation miR-19a detected by RT-qPCR. Participation regulation gene methylation studied an overexpression assay, followed RT-qPCR MSP analyses. cell proliferation...
<h3>Background</h3> We tested the hypothesis that a novel vaccine developed from autologous dendritic cells (DC) loaded with unique allogeneic brain tumor cell line (GBM6-AD) would be well-tolerated and generate an immune response. <h3>Method</h3> Patients recurrent primary tumors underwent vaccination GBM6-AD/DC vaccine. Subjects were treated at escalating DC doses: 5 × 10<sup>6</sup> (one patient), 10 patient) 15 (6 patients). Subcutaneous injections planned for days 0, 14, 28, 42, 56,...
Abstract Background This study aims to evaluate the role of fibrinogen/albumin ratio (FAR) in predicting platinum resistance and survival outcomes patients with ovarian clear cell carcinoma (OCCC). Methods Coagulation function D-dimer, serum albumin, CA125 HE4 levels were measured before surgery OCCC undergoing initial our institution. FAR was calculated as level. The correlation between these indicators clinicopathological features, response, further analyzed. Kaplan-Meier method...
The aim of this study was to investigate the effect femtosecond laser‑assisted cataract surgery (FLACS) on tear film and ocular surface function. Patients with age‑related who underwent phacoemulsification (phaco) in Air Force Aviation Medicine Research Institute Affiliation Hospital from January 2016 December were randomly divided into two groups. experimental group (n=123, 150 eyes) received FLACS, while patients phaco (n=110, conventional coaxial micro‑incision implanted foldable...
Triggering receptor expressed on myeloid cells‑1 (TREM1) is a cell‑surface protein tumor‑associated macrophages (TAMs), the predominant inflammatory cells in tumor microenvironment; however, mechanisms for influence of TREM1 TAM polarization during liver cancer progression have not been investigated. In present study, 20 patients diagnosed with hepatocellular carcinoma (HCC) who underwent surgery were enrolled, and expression M1/M2 M2 was assessed by immunohistochemical staining. Human...
Background Knowledge about tuberculosis (TB) is important for TB control, and China's national control guidelines emphasise health promotion. A 2010 epidemiology survey showed that the general public had limited knowledge awareness of TB. Objective To assess level after 5 years promotion in Guizhou Province, one regions with highest burden China. Design setting community-based, cross-sectional 10 237 residents Province from June to August 2015. Multiple logistic regression models were used...
To compare the effectiveness of upper punctal occlusion versus that lower in dry eye patients.One eye's punctum and contralateral were occluded with collagen plugs 20 patients. The same procedure was performed normal subjects. tear menisci imaged simultaneously by real-time OCT before repeated on days 1, 4, 7, 10 afterward. subjective symptom score, corneal fluorescein staining intensity, Schirmer I test result, breakup time (TBUT) also determined.In patients, either improved scores, TBUT,...
Dendritic cells (DCs) are key effectors in innate immunity and play critical roles triggering adaptive immune responses. FLT3 ligand (FLT3-L) is essential for DC development from hematopoietic progenitors. In a phase I clinical trial, we demonstrated that immunotherapy with subcutaneous injection of FLT3-L safe well tolerated cancer patients recovering autologous cell transplantation (HCT). administration significantly increased the frequency absolute number blood precursors without...
Multidrug‑resistant tumor cells can tolerate different structures, functions and antidrug action mechanisms, therefore, allowing these to respond various structurally unrelated mechanisms of chemotherapy drugs exhibit cross‑resistance. The present study aimed investigate the role Multi‑drug resistance gene (MDR1), Placental glutathione S‑transferase‑P1 (GSTP1), Lung protein (LRP) Ras association domain family member 1 (RASSF1A) in primary epithelial ovarian cancer (PEOC). mRNA (protein)...