A5040075588- Cardiac Arrhythmias and Treatments
- Lymphoma Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Acute Myeloid Leukemia Research
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- T-cell and Retrovirus Studies
- Hematological disorders and diagnostics
- Climate Change and Health Impacts
- Viral-associated cancers and disorders
- Venous Thromboembolism Diagnosis and Management
- Chronic Myeloid Leukemia Treatments
- Effects and risks of endocrine disrupting chemicals
- Kruppel-like factors research
- Mercury impact and mitigation studies
- Acute Lymphoblastic Leukemia research
- Noise Effects and Management
- Multiple Myeloma Research and Treatments
- RNA modifications and cancer
Institute of Hematology & Blood Diseases Hospital
2012-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Chinese Center For Disease Control and Prevention
2020-2025
China-Japan Friendship Hospital
2022-2025
Beijing Friendship Hospital
2024-2025
Capital Medical University
2024-2025
Affiliated Hospital of Nantong University
2025
Nantong University
2025
Nanjing Drum Tower Hospital
2021-2025
National Clinical Research
2023-2025
This study explores the feasibility of left bundle branch pacing (LBBP) and characterizes electrocardiogram (ECG) patterns during in comparison with conventional right ventricular (RVP).Forty pacing-indicated patients were prospectively enrolled. Twenty underwent LBBP (the group), 20 RVP group). Left was achieved by transseptal method basal septum. Electrocardiogram characteristics, parameters, sites, safety events assessed at implantation 3-month follow-up. In group, lead successfully...
Abstract Boron neutron capture therapy (BNCT) is an attractive approach to treat invasive malignant tumours due binary heavy-particle irradiation, but its clinical applications have been hindered by boron delivery agents with low in vivo stability, poor biocompatibility, and limited application of combinational modalities. Here, we report boronsome, a carboranyl-phosphatidylcholine based liposome for BNCT chemotherapy. Theoretical simulations experimental approaches illustrate high stability...
Mantle cell lymphoma (MCL) is a phenotypically and genetically heterogeneous malignancy in which the genetic alterations determining clinical indications are not fully understood. Here, we performed comprehensive whole-exome sequencing analysis of 152 primary samples derived from 134 MCL patients, including longitudinal 16 patients matched RNA-Seq data 48 samples. We classified into 4 robust clusters (C1-C4). C1 featured mutated immunoglobulin heavy variable (IGHV), CCND1 mutation,...
Acute myocardial infarction (AMI) is associated with well-established metabolic risk factors, especially hyperlipidemia and obesity. Myocardial ischemia-reperfusion injury (mIRI) significantly offsets the therapeutic efficacy of revascularization. Previous studies indicated that disrupted lipid homeostasis can lead to peroxidation damage inflammation, yet underlying mechanisms remain unclear. Here, study demonstrates a key driver mIRI. Long-chain fatty acyl-CoA synthetase 1 (ACSL1)...
Some epidemiological studies support a relationship between nickel exposure and diabetes in the general population. To address this, we tested association of with 10,890 adults aged ≥ 18 years old from China National Human Biomonitoring study conducted 2017-2018. Urinary concentrations fasting blood glucose (FBG) were measured, lifestyle demographic data collected. Weighted logistic linear regressions used to estimate associations urinary levels prevalence FBG. Restricted cubic splines (RCS)...
To evaluate the mutation frequency of JAK2 V617F, exon 12, MPL 10, and CALR 9 value combined tests in diagnosis BCR-ABL1–negative myeloproliferative neoplasms (MPNs). In current study, mutations were analyzed 929 Chinese patients with MPN, including 234 cases polycythemia vera (PV), 428 ETs, 187 PMFs, 80 unclassifiable MPNs (MPN-Us). Our result showed that positive rate any four PV, ET, PMF, MPN-U was 89.3%, 83.4%, 87.2%, 77.5%, respectively, which significantly improved diagnostic rate,...
Preterm birth (PTB) was one of the leading causes neonatal death. Predicting PTB in first trimester and second will help improve pregnancy outcomes. The aim this study is to propose a prediction model based on machine learning algorithms for PTB. Data were reviewed from 2008 2018, all participants included selected hospital China. Six algorisms, including Naive Bayesian (NBM), support vector (SVM), random forest tree (RF), artificial neural networks (ANN), K-means, logistic regression, used...
Left bundle branch pacing (LBBP) is a technique for conduction system pacing, but it often results in right block morphology on the ECG. This study was designed to assess simultaneous of left and areas achieve more synchronous ventricular activation. In symptomatic bradycardia patients, distal electrode bipolar lead placed at area via transventricular-septal approach. used pace area, while ring area. Bilateral (BBBP) achieved by stimulating cathode anode various configurations. QRS duration,...
Abstract Aims The present study was to evaluate the feasibility and clinical outcomes of left bundle branch area pacing (LBBAP) in cardiac resynchronization therapy (CRT)-indicated patients. Methods results LBBAP performed via transventricular septal approach 25 patients as a rescue strategy 5 with failed ventricular (LV) lead placement primary remaining 20 Pacing parameters, procedural characteristics, electrocardiographic, echocardiographic data were assessed at implantation follow-up. Of...
Abstract Background Current prognostic risk scoring systems and biomarkers are routinely used as non-invasive methods for assessing late recurrence of atrial fibrillation (AF) in patients who have undergone radiofrequency catheter ablation (RFCA). This study aimed to investigate the predictive value triglyceride-glucose (TyG) index AF after RFCA non-diabetic patients. Methods In total, 275 with underwent at Fuwai hospital (Beijing, China) between January 2016 December 2018 were enrolled this...
Adverse childhood experiences (ACEs) are associated with asthma, but the role of depressive symptoms (DS) in this is poorly studied. The aim study was to investigate mediating effect DS on ACEs and asthma. This a retrospective cohort participants from China Longitudinal Study Health Retirement 2011 2018. A total 12,277 including 5942 males 6335 females were involved study. assessed using 10-item short form Center for Epidemiological Research Depression Scale. Logistic regression adjusted...
Abstract Background To investigate the mechanisms by which SATB2 deficiency leads to impaired intestinal mucosal repair in inflammatory bowel disease, and evaluate therapeutic potential of peptide YY (PYY) ameliorating intrinsic defects epithelium. Methods Flow cytometry was used detect correlation between colonic epithelial a radiation-induced injury model. Colonic impairment validated knockout mice. The impact loss on enteroendocrine hormones, particularly PYY, its influence were assessed...
Low birth weight is recognized as a risk factor for adult metabolic and cardiovascular diseases. This study investigates whether term low (TLBW) neonates, who have been exposed to unfavorable settings, demonstrate compromised lipid metabolism. A widely targeted lipidomic analysis was conducted using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) on 59 plasma samples (28 TLBW 31 normal (TNBW) neonates. We univariate multivariate analyses identify differential...
The prevalence of childhood overweight and obesity in China has been rapidly increasing recent years. purposes this study were to investigate the infant Beijing explore influencing factors using a generalized estimating equation (GEE) model. This is birth cohort from January 2022 December Beijing, involving 2,008 newborns local residents. Four times follow-up visits conducted at 2, 5, 8, 12 months age for physical measurements health information collection. Multiple exposures considered,...
Per- and polyfluoroalkyl substances (PFASs) can impact various systems in the human body. However, their influence on biological aging remains unclear. This study aims to investigate association between PFASs exposure based data from 9756 participants China National Human Biomonitoring Program assesses potential moderating effect of Dietary Diversity Score (DDS). Biological age indexes were calculated using Klemera-Doubal method (KDM) Mahalanobis distance (MD). The DDS was consumption...
Abstract Motivation Crohn’s disease (CD) exhibits substantial variability in response to biological therapies such as ustekinumab (UST), a monoclonal antibody targeting interleukin-12/23. However, predicting individual treatment responses remains difficult due the lack of reliable histopathological biomarkers and morphological complexity tissue. While recent deep learning methods have leveraged whole-slide images (WSIs), most effective mechanisms for selecting relevant regions integrating...