A5072326707- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Marine animal studies overview
- Hydrology and Watershed Management Studies
- Hippo pathway signaling and YAP/TAZ
- Diagnosis and treatment of tuberculosis
- Soil and Water Nutrient Dynamics
- Microbial Metabolic Engineering and Bioproduction
- Microbial Natural Products and Biosynthesis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders
- Groundwater and Isotope Geochemistry
- Water Quality and Pollution Assessment
- Plant Molecular Biology Research
- Digestive system and related health
- Plant biochemistry and biosynthesis
- Urban Stormwater Management Solutions
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Plant Genetic and Mutation Studies
Soochow University
2015-2025
Second Affiliated Hospital of Soochow University
2015-2025
The University of Texas MD Anderson Cancer Center
2020-2025
Nanjing University
2020-2025
Tianjin University
2025
Chinese Academy of Sciences
2013-2024
Peking University
2024
Nanjing Medical University
2024
Cornell University
2016-2023
Cangzhou Central Hospital
2020-2022
Birds of a feather sing together How do birds know that song they hear is from member their own species, and how learn songs in the first place? Araki et al. identified two types brain cells involved finches (see Perspective by Tchernichovski Lipkind). When zebra were raised Bengalese finch foster parents, learned whose morphology resembled father. However, temporal structure remained finch–specific, suggesting it innate. Gadagkar recorded activity specific dopamine neurons singing while...
Chili pepper (Capsicum) is known for its unique fruit pungency due to the presence of capsaicinoids. The evolutionary history capsaicinoid biosynthesis and mechanism their tissue specificity remain obscure lack high-quality Capsicum genomes. Here, we report two telomere-to-telomere (T2T) gap-free genomes C. annuum wild nonpungent relative rhomboideum investigate evolution in chili peppers. We precisely delineate centromeres, which high-copy tandem repeats but are extensively invaded by CRM...
Abstract Background Aeromonas hydrophila is a serious pathogen and can cause hemorrhagic septicemia in fish. To control this disease, antibiotics chemicals are widely used which consequently result "superbugs" chemical accumulation the food chain. Though vaccine against A. available, its use limited due to multiple serotypes of problems safety efficacy. Another problem with vaccination ability apply it small fish especially high numbers. In study, we tried new way attenuate infection by...
A 92 kb silent hybrid polyketide and nonribosomal peptide gene cluster in marine-derived Streptomyces pactum SCSIO 02999 was activated by genetically manipulating the regulatory genes, including knockout of two negative regulators (totR5 totR3) overexpression a positive regulator totR1, to direct production known totopotensamides (TPMs) (1) B (3) novel sulfonate-containing analogue TPM C (2). Inactivation totG led accumulation lacking glycosyl moiety, which indicated TotG as dedicated...
Single-cell transcriptomics has been fully embraced in plant biological research and is revolutionizing our understanding of growth, development, responses to external stimuli. However, single-cell transcriptomic data analysis plants not trivial, given that there currently no end-to-end solution integration various bioinformatics tools involves a large number required dependencies. Here, we present scPlant, versatile framework for exploring atlases with minimum input provided by users. The...
<title>Abstract</title> <bold>Background</bold> Impaired colonic mucosal repair is a critical issue in inflammatory bowel diseases (IBD). SATB2 essential for maintaining epithelial homeostasis, but its role unclear.<bold>Objective</bold> To investigate how deficiency impairs IBD and assess the therapeutic potential of peptide YY (PYY) enhancing regeneration.<bold>Design</bold> Flow cytometry was used to SATB2’s radiation injury model. knockout mice were validate impairment. The effect loss...
We use our experiences to form and update beliefs about the hidden states of world. When possible, we also gather evidence by observing others. However, how brain integrates experiential observational is not understood. studied dynamics integration in a two-player game with volatile states. Both humans monkeys successfully updated their while playing partner, though less effectively when observing. Electrophysiological recordings animals revealed that anterior cingulate cortex (ACC)...
Agricultural activities such as fertilization and cultivation constitute a substantial source of non-point (NPS) nitrogen (N) in aquatic ecosystems. Precise quantification fluxes across diverse land uses identification critical areas are essential for effectively mitigating loads. In this study, the Soil Water Assessment Tool (SWAT) was employed to accurately model watershed hydrology total (TN) transport Zhongtian River Basin, i.e., an agricultural characterized by low mountainous terrain....
Circulating tumor cells (CTCs) serve as valuable biomarkers in circulation, carrying essential primary information. The purification of CTCs from peripheral blood samples and the analysis their characteristic molecules enable detection tumors at an early stage. noninvasive, continuous, real-time dynamic monitoring provides a promising solution for timely diagnosis colorectal cancer (CRC). In this study, we developed minimally invasive method CRC to accurate screening friendly manner...
Abstract Impaired colonic mucosal repair is a critical issue in inflammatory bowel diseases (IBD). SATB2 essential for maintaining epithelial homeostasis, but its role unclear. In this study, flow cytometry was used to assess SATB2’s radiation injury model. knockout mice exhibited defective repair, with marked reduction goblet and enteroendocrine cells. Mechanistically, directly regulated PPAR-γ transcription, PYY observed translocate into the nucleus promote transcription of target genes....
Abstract Motivation Crohn’s disease (CD) exhibits substantial variability in response to biological therapies such as ustekinumab (UST), a monoclonal antibody targeting interleukin-12/23. However, predicting individual treatment responses remains difficult due the lack of reliable histopathological biomarkers and morphological complexity tissue. While recent deep learning methods have leveraged whole-slide images (WSIs), most effective mechanisms for selecting relevant regions integrating...
The antibacterial and antiviral agent amicetin is a disaccharide nucleoside antibiotic featuring unique α-(1→4)-glycoside bond between amosamine amicetose, characteristic of retaining glycosylation. In this study, two key steps for biosynthesis were investigated: the N-methyltransferase AmiH was demonstrated to be requisite dimethylation in amosamine, glycosyltransferase AmiG shown necessary amosaminylation. Biochemical kinetic characterization revealed first time catalytic reversibility...
Abstract Acute lung injury (ALI) is a highly lethal pulmonary disease that causes edema, hypoxemia and respiratory failure. Recent evidence indicates nuclear factor-kappa B (NF-κB) plays crucial role in ALI development. However, the regulatory mechanism of NF-κB on remains enigmatic. In this study, we investigated potential molecular induced by lipopolysaccharide (LPS). BALB/c mice were subjected to intratracheal spraying LPS generate an mode, with activity tissues being detected enzyme...
Acute lung injury (ALI), is a rapidly progressing heterogenous pulmonary disorder that possesses high risk of mortality. Accumulating evidence has implicated the activation p65 subunit NF-κB [NF-κB(p65)] in pathological process ALI. microRNAs (miRNAs), group small RNA molecules, have emerged as major governors due to their post-transcriptional regulation gene expression wide array processes, including The dysregulation miRNAs and been human diseases. In current study, we set out decipher...
Abstract Purpose Mucosal healing (MH) has become the treatment goal of patients with Crohn’s disease (CD). This study aims to develop a noninvasive and reliable clinical tool for individual evaluation mucosal in disease. Methods A multicenter retrospective cohort was established. Clinical serological variables were collected. Separate risk factors incorporated into binary logistic regression model. primary model simple established, respectively. The performance evaluated C-index,...