A5101777110- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Bone health and treatments
- Cancer-related gene regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Hippo pathway signaling and YAP/TAZ
- Bone and Dental Protein Studies
- MicroRNA in disease regulation
- Retinal Diseases and Treatments
- Caveolin-1 and cellular processes
- IL-33, ST2, and ILC Pathways
- Microbial metabolism and enzyme function
- Protein Degradation and Inhibitors
- Dietary Effects on Health
- Molecular Biology Techniques and Applications
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- Proteins in Food Systems
- Receptor Mechanisms and Signaling
- Telomeres, Telomerase, and Senescence
The University of Texas MD Anderson Cancer Center
2017-2025
Beijing Technology and Business University
2024-2025
Chongqing Medical University
2023-2024
Nanjing University of Chinese Medicine
2023
Guangdong Medical College
2021
Second Affiliated Hospital of Chengdu University of Traditional Chinese
2013
Chengdu University of Traditional Chinese Medicine
2013
Sichuan University
2013
Molina Center for Energy and the Environment
2013
Stanford University
2009
Abstract Genetic inactivation of PTEN is common in prostate cancer and correlates with poorer prognosis. We previously identified CHD1 as an essential gene PTEN-deficient cells. Here, we sought definitive vivo genetic evidence for, mechanistic understanding of, the role cancer. In Pten Pten/Smad4 genetically engineered mouse models, prostate-specific deletion Chd1 resulted markedly delayed tumor progression prolonged survival. was associated profound microenvironment (TME) remodeling...
Abstract Germline telomere maintenance defects are associated with an increased incidence of inflammatory diseases in humans, yet whether and how dysfunction causes inflammation not known. Here, we show that drives pATM/c-ABL-mediated activation the YAP1 transcription factor, up-regulating major pro-inflammatory pro-IL-18. The colonic microbiome stimulates cytosolic receptors activating caspase-1 which cleaves pro-IL-18 into mature IL-18, leading to recruitment interferon (IFN)-γ-secreting T...
Endothelial cell senescence is one of the most important causes vascular dysfunction and atherosclerosis. Circular RNAs (circRNAs) are endogenous RNA molecules with covalently closed-loop structures, which have been reported to be abnormally expressed in many human diseases. However, potential role circRNAs endothelial atherosclerosis remains largely unknown. Here, we compared expression patterns young senescent cells sequencing. Among differentially circRNAs, circGNAQ, a circRNA enriched...
Immune checkpoint therapy has limited efficacy for patients with bone-metastatic castration-resistant prostate cancer (bmCRPC). To improve immunotherapy bmCRPC, we aimed to identify the mechanism of bmCRPC-induced changes in immune microenvironment. Among bmCRPC patients, higher levels a 32-gene M2-like macrophage signature bone metastasis samples correlated shorter overall survival. Immunohistochemistry showed that CD206-positive (CD206
Mice homozygous for a dominant-negative allele of the Clock gene ( Δ 19/Δ 19 ) have slightly but significantly decreased male fertility. The molecular mechanism this reduction in fertility is unknown. In present study, we used small hairpin RNA (shRNA) strategy to specifically knock down expression testes mice and determined its effect on knockdown led smaller litter size, lower vitro rate, blastula formation acrosin activity sperm. Locomotor analysis revealed that did not alter their...
Abstract Despite receiving surgical or medical castration, most prostate cancer (PCa) patients eventually progress to castration-resistant (CRPC), where the androgen receptor (AR) continues drive disease progression. Genomic studies have identified a unique subtype of PCa marked by mutations in speckle-type BTB/POZ protein (SPOP), which lead stabilization AR and its co-activators been associated with prolonged responses deprivation therapies favorable prognoses. However, SPOP frequently...
Abstract Bone metastasis is a major cause of cancer death; however, the epigenetic determinants driving this process remain elusive. Here, we report that histone methyltransferase ASH1L genetically amplified and required for bone in men with prostate cancer. rewires methylations cooperates HIF-1α to induce pro-metastatic transcriptome invading cells, resulting monocyte differentiation into lipid-associated macrophage (LA-TAM) enhancing their pro-tumoral phenotype metastatic niche. We...
Cell type transition occurs during normal development and under pathological conditions. In prostate cancer bone metastasis, cancer-secreted BMP4 induces endothelial cell-to-osteoblast (EC-to-OSB) transition. Such tumor-induced stromal reprogramming supports progression. We delineate signaling pathways mediating EC-to-OSB using EC lines 2H11 SVR. found that BMP4-activated pSmad1-Notch-Hey1 pathway inhibits migration tube formation. GSK3β-βcatenin-Slug stimulates Osx expression. addition,...
Abstract Clinical studies have shown that subsets of patients with cancer achieve a significant benefit from Aurora kinase inhibitors, suggesting an urgent need to identify biomarkers for predicting drug response. Chromodomain helicase DNA binding protein 1 (CHD1) is involved in chromatin remodeling, repair, and transcriptional plasticity. Prior demonstrated CHD1 has distinct expression patterns cancers different molecular features, but its impact on responsiveness remains understudied....
With the development of society and deepening aging degree, problems neurodegenerative diseases are increasing, which has aroused widespread concern in society.Neurodegenerative seriously related to people's quality life.Microglia innate immune effector cells central nervous system play an important role physiological processes system.The activation microglia inflammation-mediated neurotoxicity some diseases.The form programmed cell death is apoptosis, caspase-8 apical component pathways,...
Hydrogen-rich materials offer a compelling avenue towards room temperature superconductivity, albeit under ultra-high pressure. However, the experimental investigation of electronic band structure remains elusive, due to inherent instability most hydrogen-rich upon pressure release. Very recently, nitrogen-doped lutetium hydride was claimed host superconductivity near ambient but disproven by following works. Upon decompression, nitrogen doped manifests stable metallic phase with dark blue...
<title>Abstract</title> Previous studies have indicated that impaired synaptic plasticity is a main pathological alteration in depression. However, the mechanism underlying this change has not been clarified. Adiponectin, an adipokines, crosses blood-brain barrier to function special brain regions. suggested downregulation of adiponectin signaling involved occurrence Adiponectin receptors (AdipoRs), AdipoR1 and AdipoR2, which serves as for central nervous system, mediate downstream...