A5101812031- Acupuncture Treatment Research Studies
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Treatment of Major Depression
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Gut microbiota and health
- Traditional Chinese Medicine Analysis
- Cardiac electrophysiology and arrhythmias
- Traditional Chinese Medicine Studies
- Metabolomics and Mass Spectrometry Studies
- Medicinal Plants and Bioactive Compounds
- Phytochemistry and Biological Activities
- Rheumatoid Arthritis Research and Therapies
- Plant-based Medicinal Research
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Imaging and Diagnostics
- Tuberculosis Research and Epidemiology
- Transplantation: Methods and Outcomes
- Cardiac Fibrosis and Remodeling
- Genomics, phytochemicals, and oxidative stress
- Signaling Pathways in Disease
Beijing University of Chinese Medicine
2017-2024
Guangxi University of Chinese Medicine
2024
Heilongjiang University of Chinese Medicine
2013-2024
Air Force Medical University
2022-2024
Xijing Hospital
2024
Russian University of Transport
2024
China-Japan Friendship Hospital
2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2018-2023
First Affiliated Hospital of Kunming Medical University
2023
Kunming Medical University
2023
Abstract Drug-induced liver injury (DILI) has always been the focus of clinicians and drug researchers. How to improve performance DILI prediction model accurately predict was an urgent problem for researchers in field medical research. In order solve this scientific problem, research collected a comprehensive accurate dataset with high recognition quality based on clinically confirmed compound datasets, including 1446 chemical compounds. Then, residual neural network 18-layer by using more...
To explore the effects of acupuncture (manual or electroacupuncture) combined with SSRIs for moderate to severe depression improving major clinical symptoms and life quality patients on secondary outcomes.Pragmatic, parallel, randomized controlled trial.6 hospitals in China.6 weeks manual (MA)+selective serotonin reuptake inhibitors (SSRIs), electroacupuncture (EA)+SSRIs, alone.The primary outcome was response rate 17-item Hamilton Depression Scale (HAMD-17) total score at 6th week. The...
Sensitive and stable biomarkers that facilitate depression detection monitor the antidepressant efficiency are currently unavailable. Thus, objective is to investigate potential of DNA methylation histone modifications brain-derived neurotrophic factor (BDNF) in monitoring severity antidepressive effects acupuncture. The rat model was imitated by social isolation chronic unpredicted mild stress (CUMS). expression serum BDNF detected ELISA, hippocampal BDNF, acH3K9 HDAC2 WB, mRNA RT-PCR....
Traditional Chinese medicine and Western combination (TCM-WMC) increased the complexity of compounds ingested.To develop a method for screening hepatotoxic in TCM-WMC based on chemical structures using artificial intelligence (AI) methods.Drug-induced liver injury (DILI) data was collected from public databases published literatures. The total dataset formed by DILI randomly divided into training set test at ratio 3:1 approximately. Machine learning models SGD (Stochastic Gradient Descent),...
Major depressive disorder (MDD) is a chronic disease that adversely affects mood and cognition. In this study, we randomly divided the rats into control group (C), model (M), fluoxetine (F), acupuncture (A), used open-field test to ascertain whether restraint stress (CRS) induced depression-like behaviors of rats, explored antidepressant mechanism at molecular level transcriptome in frontal cortex CRS by RNA-sequencing (RNA-seq). According differentially expressed genes (DEG) analysis,...
Importance: The incidence of Bradyarrhythmias is high among the population. However, at early stages disease, it cannot always get enough attention and lack safe effective therapies, until serious to resort pacemaker implantation. Traditional Chinese Medicine (TCM) has a long history treating Bradyarrhythmia, with lot formulas being widely used in clinical practice. While effectiveness underlying mechanisms these have not yet been clearly identified. Objective: To evaluate some common TCM...
The highly heterogeneous pathogenesis of depression and limited response to current antidepressants call for more objective evidence subtypes. Reactive endogenous are two etiologically distinct subtypes associated with different treatment responses. This study aims explore the potential biomarkers that differentiate reactive depressions.The clinical manifestations biological indicators 64 unmedicated mild-to-moderate patients (32 32 patients) 21 healthy subjects were observed. 24-item...
Acupuncture has demonstrated the function in ameliorating depressive-like behaviors via modulating PKA/CREB signaling pathway. To further confirm antidepressant mechanism of EA on mitogen-activated protein kinase (MAPK) and dopaminergic synapse pathways, 4 target proteins were detected based our previous iTRAQ analysis. Rats randomly divided into control group, model electroacupuncture (EA) group. Except for all rats subjected to 28 days chronic restraint stress (CRS) protocols induce...
Background: There is evidence supporting electroacupuncture (EA) for the treatment of major depressive disorder (MDD), but its characteristics have not been well investigated. Objective: To investigate effectiveness and EA in MDD. Methods: 60 subjects were enrolled—35 group 25 selective serotonin reuptake inhibitor (SSRI) based on their preferences—in an 8-week non-randomised controlled clinical trial. The 24-item Hamilton depression rating scale (HAMD-24) global impression (CGI) adopted...
Abstract Dilated cardiomyopathy (DCM) is the leading cause of heart transplantation. By microRNA (miRNA) array, a Kaposi’s sarcoma-associated herpes virus (KSHV)-encoded miRNA, kshv-miR-K12-1-5p, was detected in patients with DCM. The KSHV DNA load and kshv-miR-K12-1-5p level plasma from 696 DCM were measured these followed-up. Increased seropositivity quantitative titers found compared non-DCM group (22.0% versus 9.1%, p < 0.05; 168 14 copies/mL plasma, 0.05). risk individual end point...
Purpose This study aimed to provide a comprehensive understanding of the genome-wide expression patterns in synovial tissue samples patients with rheumatoid arthritis (RA) investigate potential mechanisms regulating RA occurrence and development. Methods Transcription profiles from nine 15 osteoarthritis (OA) (control) East Asian population were generated using RNA sequencing (RNA-seq). Gene set enrichment analysis (GSEA) was used analyze all detected genes differentially expressed (DEGs)...
Application of the anticancer drug doxorubicin (DOX) is restricted due to its adverse, cardiotoxic side effects, which ultimately result in heart failure. Moreover, there are a limited number chemical agents for clinical prevention DOX-induced cardiotoxicity. Based on theories traditional Chinese medicine (TCM) chronic failure (CHF), Shenlijia (SLJ), new TCM compound, has been developed fulfill multiple functions, including improving cardiac function and inhibiting fibrosis. In present...
Abstract The effectiveness and safety of electroacupuncture (EA) for depression have been identified by abundant clinical trials experimental findings. c‐Jun‐NH(2)‐terminal kinase (JNK) signaling pathway is considered to be involved in the antidepressant mechanism EA. However, effect EA via modulating expression c‐Fos/activator protein‐1 (AP‐1) under condition JNK inhibition remains unexplored. In this study, we investigated possible regulating c‐Fos/AP‐1 SP600125 rats exposed chronic...
Background: The systems pharmacology approach is a target prediction model for traditional Chinese medicine and has been used increasingly in recent years. However, the accuracy of this to other models yet be established. Objective: To compare modelwithexperimental gene chip technology by using these predict targets formulain treatment primary liver cancer. Methods: Systems predictions were performed formula ZhenzhuXiaojiTang (ZZXJT). A third square alignment was with molecular docking....