A5008782532- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Berberine and alkaloids research
- Computational Drug Discovery Methods
- Healthcare and Venom Research
- Metabolomics and Mass Spectrometry Studies
- Biological and pharmacological studies of plants
- IL-33, ST2, and ILC Pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Dermatology and Skin Diseases
- Medical Imaging and Pathology Studies
- Sphingolipid Metabolism and Signaling
- Gastric Cancer Management and Outcomes
- Bioactive Compounds and Antitumor Agents
- Autophagy in Disease and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Allergic Rhinitis and Sensitization
- Plant-based Medicinal Research
Nanjing University of Chinese Medicine
2022-2024
Heilongjiang University of Chinese Medicine
2022
RMIT University
2019-2021
Shanghai Municipal Commission of Health and Family Planning
2021
Central South University
2021
Shandong University of Traditional Chinese Medicine
2020
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2020
Chinese National Human Genome Center
2019
The Military General Hospital of Beijing PLA
2017
Fisetin, a natural potent flavonoid, has various beneficial, pharmacological activities. In this study, we investigated expression changes of the fisetin regulating genes in lipopolysaccharide (LPS)-treated RAW264.7 cells and explored role inflammation autophagy.Microarray analysis identified 1,071 that were regulated by LPS-treated cells, these mainly related to process immune system response. Quantitative real-time polymerase chain reaction Bio-Plex indicated decreased secretion several...
COVID-19 caused by SARS-CoV-2 infection has been spreading through many countries since the end of 2019. The 4th edition national guidelines for management provides an herbal formula with 9 herbs its management. Aim Study. We aimed to predict mechanism binding and SARS-CoV spike glycoproteins angiotensin-converting enzyme 2 (ACE2) provide a molecular-level explanation higher pathogenicity identify protein sites which may be targeted therapeutic agents disrupt virus-host interactions....
Xing-Nao-Jing (XNJ) is a well-known injection that has been extensively applied in clinical treatment of stroke China. However, the underlying mechanism administration XNJ remains unclear. In this study, systems pharmacology strategy based on pharmacokinetic and pharmacodynamics data was to analyze pharmacological effect stroke. Sixteen active compounds were filtered from through Drug-likeness (DL) Brain-blood-barrier (BBB) evaluations. Ninety-four potential targets these components...
Background: The systems pharmacology approach is a target prediction model for traditional Chinese medicine and has been used increasingly in recent years. However, the accuracy of this to other models yet be established. Objective: To compare modelwithexperimental gene chip technology by using these predict targets formulain treatment primary liver cancer. Methods: Systems predictions were performed formula ZhenzhuXiaojiTang (ZZXJT). A third square alignment was with molecular docking....
Background: Gefitinib is well-known as a tyrosine kinase inhibitor targeting non-smalllung- cancer (NSCLC) containing EGFR mutations. However, its effectiveness in treating mucoepidermoid carcinoma (MEC) without such mutations suggests additional targets. Objective: The CRTC1-MAML2 (C1-M2) fusion typical for MEC has been proposed to be gefitinib target. Methods: To test this hypothesis, we developed set of siRNAs down-regulate C1-M2 expression. RNA-seq and Western blot techniques were...
Liver cancer is one of the most common digestive tumors. The prescription Zhenzhu Xiaoji decoction (ZZXJD) has a certain effect on growth and survival primary liver cancer. Object: This article aimed to explore molecular mechanism ZZXJD SMMC-7721 cells.The research groups were divided into model group, cisplatin group. cells treated with different concentrations ZZXJD-medicated serum for 24 h 48 h. cell viability was measured CCK8 assay, morphology observed by fluorescence microscope...
This study aims to decipher the mechanism of sinomenine in inhibiting platelet-derived growth factor/platelet-derived factor receptor(PDGF/PDGFR) signaling pathway rheumatoid arthritis-fibroblast-like synoviocyte(RA-FLS) migration induced by neutrophil extracellular traps(NETs). RA-FLS was isolated from synovial tissue 3 RA patients and cultured. NETs were extracted peripheral venous blood 4 healthy control(HC). classified into control group, HC-NETs RA-NETs RA-NETs+sinomenine group...
With a high incidence and limited treatments, gastric cancer (GC) seriously threatens human health worldwide. Weikang Keli (WK) is compound prescription summed up from clinical experience. In our previous studies, WK has been proved to exert antitumor effects. However, there are no research studies discuss verify its mechanism as compound.The aim of the study explore potential molecular in treatment GC with aid network pharmacology it through experiments.Related databases were used obtain...
The exploration and identification of targets pathways for Atopic dermatitis (AD) treatment diagnosis are critical AD control. conventional target approach such as the literature review is not satisfying in terms efficiency accuracy. Recently, bioinformatic drawing attention its unique advantage high-volume data analysis pathway exploration; Open Targets Platform source this study to extract top 200 high-rank proteins from 3122 associated proteins. STRING, Cytoscape, CytoHubba, ClueGo,...
e21082 Background: The clinical value of combined local radiation and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) for medical inoperable TKI-naïve early-stage lung adenocarcinoma patients with EGFR mutations is not yet determined. In this study, we aimed to pool multi-institutional data compare the therapeutic effect EGFR-TKI alone TKI on survival outcomes in patient subgroup. Methods: 132 cases non-operable stage I III mutant were retrospectively reviewed based...