A5074071387- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Screening and Detection
- Cancer-related gene regulation
- Pancreatitis Pathology and Treatment
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Renal cell carcinoma treatment
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Hops Chemistry and Applications
- Phytochemical compounds biological activities
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Toxoplasma gondii Research Studies
- Cancer Genomics and Diagnostics
Huazhong University of Science and Technology
2017-2025
Tongji Hospital
2017-2025
Several natural products have been demonstrated to both enhance the anti-tumor efficacy and alleviate side effects of conventional chemotherapy drugs.Rhein, a main constituent Chinese herb rhubarb, has shown induce apoptosis in various cancer types.However, exact pharmacological mechanisms controlling influence Rhein on drug pancreatic (PC) remain largely undefined.In this study, we found that inhibited growth proliferation PC cells through G1 phase cell cycle arrest.Moreover, induced...
Pancreatic ductal adenocarcinoma is one of the most aggressive cancers, with a 5-year survival rate less than 8%. The complicated tumor microenvironment, particularly TGF-β, provides possible convenience for progression PC cells. TGF-β regulates critical cellular processes, including autophagy. However, mechanism and effects TGF-β-mediated autophagy are still poorly understood.Bioinformatics analysis, western blot, transmission electron microscopy confocal were used to identify that TFEB key...
Abstract Dysfunction in long noncoding RNAs (lncRNAs) is reported to participate the initiation and progression of human cancer; however, biological functions molecular mechanisms through which lncRNAs affect pancreatic cancer (PC) are largely unknown. Here, we report a novel lncRNA, LINC01111, that clearly downregulated PC tissues plasma patients acts as tumor suppressor. We found LINC01111 level was negatively correlated with TNM stage but positively survival patients. The overexpression...
With a 5-year survival rate of approximately 10%, pancreatic ductal adenocarcinoma (PDAC) is one the most lethal solid malignancies in humans. A poor understanding underlying biology has resulted lack effective targeted therapeutic strategies. Tissue microarray and bioinformatics analyses have revealed that downstream transcriptional coactivator Hippo pathway, with PDZ-binding motif (TAZ), might be target PDAC. Since pharmacological inhibition TAZ challenging, we performed unbiased...
The safety and efficacy of laparoscopic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma remain controversial.
Dysregulation of regulatory B cells (Bregs), a type immunosuppressive lymphocyte, are associated with development autoimmune diseases and cancers. Bregs produce immune tolerance-inducing cell surface molecules tolerogenic cytokines (interleukin [IL]-10 transforming growth factor-beta). We previously showed that levels the inflammatory cytokine IL-18 were increased in patients pancreatic cancer. In present study study, we found cancer cell-derived increases Breg-induced immunosuppression....
Novel biomarkers for pancreatic adenocarcinoma are urgently needed because of its poor prognosis. Here, by using The Cancer Genome Atlas (TCGA) RNA-seq data, we evaluated the prognostic values differentially expressed miRNAs and constructed a five-miRNA signature that could effectively predict patient overall survival (OS). Kaplan-Meier curves two groups based on five were notably different, showing in 10.2% 47.8% at years patients high-risk low-risk groups, respectively. ROC curve analysis...
Epidermal growth factor receptor (EGFR) is an essential target for cancer treatment. However, EGFR inhibitor erlotinib showed limited clinical benefit in pancreatic therapy. Here, we the underlying mechanism of tumor microenvironment suppressing sensitivity through stellate cell (PSC). The expression alpha-smooth muscle actin (α-SMA) and hypoxia marker human tissues were detected by immunohistochemistry, their correlation with overall survival was evaluated. Human immortalized PSC...
// Xiuhui Shi 1 , Yan Zhao Ruizhi He Min Zhou Shutao Pan Shuo Yu Xie Xu Li Wang Xingjun Guo and Renyi Qin Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan, China Correspondence to: Qin, email: ryqin@tjh.tjmu.edu.cn Guo, xjguo@tjh.tjmu.edu.cn Keywords: long noncoding RNA; pancreatic adenocarcinoma; TCGA; ceRNA; prognosis Received: August 23, 2017 Accepted: February 01,...
Pancreatic cancer is the seventh leading cause of death worldwide, which demonstrated with remarkable resistance to radiotherapy and chemotherapy. The identification prognosis signature novel prognostic markers will facilitate patient stratification an individualized precision therapy strategy. In this study, TCGA-PAAD was used screen E3 ubiquitin ligases establish signatures, GEO database verify accuracy signatures. Functional analysis, in vitro experiments clinical cohort studies were...
BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in individuals who do not consume alcohol. Several risk factors influencing onset NAFLD after laparoscopic pancreaticoduodenectomy (LPD) have been identified. This study investigated associated with development duodenum-preserving pancreatic total head resection (LDPPHRt) and LPD. AIM To compare effects LDPPHRt LPD on postoperative NAFLD. METHODS retrospective cohort included 59 patients were...
Pancreatic ductal adenocarcinoma is prone to metastasis, resulting in short survival and low quality of life. LncRNAs are pivotal orchestrators that participate various tumor progress. The underlying role mechanism lncRNA FAM83H-AS1 still unknown PDAC progression.To address this issue, firstly, we profiled analyzed the aberrant expression TCGA database identified as most effective one promoting migration pancreatic cancer cells. Then, levels patient's serum, tissues cells were detected using...
Objective: This study aimed to estimate whether the potential short-term advantages of laparoscopic pancreaticoduodenectomy (LPD) could allow patients recover in a more timely manner and achieve better long-term survival than with open (OPD) pancreatic or periampullary tumors. Summary Background Data: LPD has been demonstrated be feasible may have several over OPD terms shorter hospital stay accelerated recovery OPD. Methods: noninferiority, open-label, randomized clinical trial was...
It is widely known that abnormal regulation of microRNAs (miRNAs/miRs) may contribute to the occurrence or development tumors. The objective present study was elucidate function and underlying mechanism miR‑137 in progression cholangiocarcinoma (CCA). expression levels CCA tissues cell lines were measured using reverse transcription‑quantitative PCR. role proliferation cells assessed Cell Counting Kit‑8 assay, colony formation assay cycle distribution analysis, while its effects on migration...
Introduction Pancreatic cancer is one of the deadliest cancers and pancreaticoduodenectomy (PD) recommended as optimal operation for resectable pancreatic head cancer. Minimally invasive surgery, which initially emerged hybrid-laparoscopy recently developed into total laparoscopy has been widely used various abdominal surgeries. However, controversy persists regarding whether laparoscopic PD (LPD) inferior to open (OPD) ductal adenocarcinoma (PDAC) treatment. Further studies, especially...
Abstract Background The use of laparoscopic pancreaticoduodenectomy (LPD) in pancreatic head cancer remains controversial, and an appropriate surgical approach can help improve perioperative safety oncological outcomes. This study aimed to assess the short-term outcomes long-term survival superior mesenteric artery first (SMA-first) patients with ductal adenocarcinoma (PDAC) undergoing LPD. Methods data 91 consecutive PDAC who underwent LPD from June 2014 2021 were retrospectively analyzed....
Abstract Background: Pancreatic cancer was prone to metastasis, which leaded the poor survival and low quality of life. Here, we found that FAM83H-AS1 highly correlated with metastasis pancreatic further explored functions mechanisms involving in malignant progression cancer. Method: We profiled analyzed aberrant expression lncRNA (long non-coding RNA) TCGA database screened most effective promoting migration cells. Firstly, level serum, tissues cells were detected by RT-qPCR, distribution...
Background: The safety and efficacy of laparoscopic pancreatoduodenectomy (LPD) for pancreatic ductal adenocarcinoma (PDAC) remain controversial. This trial aimed to compare open (OPD) performed by experienced surgeons patients with PDAC. article reports the early results from trial.Methods: noninferiority, multicentre, open-label was at ten hospitals in China. Patients PDAC were randomly assigned either LPD or OPD a 1:1 ratio. Randomisation centralised via computer-generated system that...