Laith Alkukhun

ORCID: 0000-0003-4913-4053
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About
Contact & Profiles
Research Areas
  • Pulmonary Hypertension Research and Treatments
  • Cardiac Arrhythmias and Treatments
  • Cardiac pacing and defibrillation studies
  • Cardiac electrophysiology and arrhythmias
  • Cardiovascular Function and Risk Factors
  • Atrial Fibrillation Management and Outcomes
  • Vascular Malformations and Hemangiomas
  • Central Venous Catheters and Hemodialysis
  • Heart Failure Treatment and Management
  • Venous Thromboembolism Diagnosis and Management
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Cardiovascular Issues in Pregnancy
  • Cardiac Arrest and Resuscitation
  • Hemodynamic Monitoring and Therapy
  • Vascular Anomalies and Treatments
  • Trauma Management and Diagnosis
  • Cardiovascular and exercise physiology
  • Empathy and Medical Education
  • Cardiovascular and Diving-Related Complications
  • Vascular Procedures and Complications
  • Liver Disease Diagnosis and Treatment
  • Organ Transplantation Techniques and Outcomes
  • Infective Endocarditis Diagnosis and Management
  • COVID-19 Clinical Research Studies
  • Optimism, Hope, and Well-being

Oregon Health & Science University
2022-2023

VA Portland Health Care System
2023

Cleveland Clinic
2013-2022

University of Pittsburgh Medical Center
2019-2021

University of Pittsburgh
2020

UPMC Health System
2019

Minnesota Gastroenterology
2016

Pulmonary Associates
2016

Creative Research Enterprises (United States)
2016

Abstract Aims Data on ventricular pulsed-field ablation (PFA) are sparse in the setting of chronic myocardial infarction (MI). The objective this study was to compare biophysical and histopathologic characteristics PFA healthy MI swine myocardium. Methods results Myocardial (n = 8) underwent coronary balloon occlusion survived for 30 days. We then performed endocardial unipolar, biphasic border zone a dense scar with electroanatomic mapping using an irrigated contact force (CF)-sensing...

10.1093/europace/euac252 article EN cc-by-nc EP Europace 2023-02-16

Background Scarce information exits on the electrocardiographic (ECG) characteristics of pulmonary arterial hypertension (PAH) patients close to their death and whether observed abnormalities progress from time PAH diagnosis. Methods We analyzed ECG performed at initial diagnosis, during course disease consecutive followed our institution between June 2008 December 2010. Results included 50 with (76% women) mean (SD) age 58 (14) years. Median heart rate (83 vs 89 bpm, P = 0.001), PR interval...

10.1111/anec.12125 article EN Annals of Noninvasive Electrocardiology 2013-12-30

Rationale: Pulmonary arterial hypertension (PAH) is a pulmonary vasculopathy that leads to failure of the right ventricle and premature death.Objectives: To determine whether sublingual microcirculation affected in patients with PAH compared healthy age- sex-matched control subjects.Methods: Using CapiScope Handheld Video Capillaroscope we measured microvasculature density, flow index, tortuosity, curvature. Videos were acquired immediately after heart catheterization, determinations made...

10.1513/annalsats.201308-277oc article EN Annals of the American Thoracic Society 2014-03-06

AIM:To investigate if echocardiographic and hemodynamic determinations obtained at the time of transjugular intrahepatic portosystemic shunt (TIPS) can provide prognostic information that will enhance risk

10.4254/wjh.v8.i11.520 article EN World Journal of Hepatology 2016-01-01

ABSTRACT Background and objective A dilated pulmonary artery ( PA ) is a common finding in patients with arterial hypertension PAH ). Little known on the variations size over time whether these changes track disease severity and/or predict long‐term survival. Methods We included who had at least two computed tomography CT scans of chest done different visits. Both matched use i.v. contrast. Results Pairs were compared 113 patients. During median (interquartile range IQR )) difference between...

10.1111/resp.13073 article EN Respirology 2017-05-17

Abstract Background Methods that predict prognosis and response to therapy in pulmonary hypertension (PH) are lacking. We tested whether the noninvasive estimation of hemodynamic parameters during 6‐minute walk test (6MWT) PH patients provides information can improve value test. estimated 6MWT using a portable, signal‐morphology‐based, impedance cardiograph (PhysioFlow Enduro) with real‐time wireless monitoring via bluetooth USB adapter. Results recruited 48 subjects study (30 18 healthy...

10.1111/cts.12090 article EN other-oa Clinical and Translational Science 2013-09-06

Prostacyclin analogs are Food and Drug Administration-approved therapies for the treatment of pulmonary arterial hypertension can be administered by inhalational, intravenous (IV), or subcutaneous (SQ) routes. Because there limited data to guide transition between SQ IV prostacyclin analogs, we describe our experience.We performed a retrospective review patients with diagnosed right heart catheterization, who underwent from analogs.We included 7 2 chronic thromboembolic in this study. Median...

10.1097/fjc.0000000000000018 article EN Journal of Cardiovascular Pharmacology 2013-10-01

Six-minute walk test (6MWT) continues to be a useful tool determine the functional capacity in patients with vascular and other lung diseases; nevertheless, it has limited ability predict prognosis this context. We tested whether heart rate (HR) acceleration decay slopes during 6-m are different pulmonary arterial hypertension (PAH), diseases, healthy controls. In addition, we assessed HR associated clinical worsening. Using portable, signal-morphology-based, impedance cardiograph...

10.14814/phy2.12038 article EN cc-by Physiological Reports 2014-06-01

Introduction: Pulmonary hypertension (PH) is an indicator of poor prognosis in COPD patients; particularly those with mean pulmonary artery pressure ≥ 40 mm Hg. Electrocardiography (ECG) might be useful for screening this condition. Methods: Retrospective study patients evaluated lung transplantation whom we analyzed the 12-lead ECG performed closest to time right heart catheterization. Results: We included 142 patients. PH was present 90 (63%) and 16 (11%) had a PAP mmHg. The PR interval...

10.3109/15412555.2014.898047 article EN COPD Journal of Chronic Obstructive Pulmonary Disease 2014-07-01

OBJECTIVES: Guidewire retention after intravascular catheter insertion is considered a “never event.” Prior reports attribute this complication to various characteristics including uncooperative patients, operator inexperience, off-hour or emergent insertion, and underutilization of ultrasound guidance. In descriptive analysis consecutive events, we assessed the frequency patient, operator, procedural factors in guidewire retention. DESIGN: Pre-specified observational as part quality...

10.1097/cce.0000000000000834 article EN cc-by-nc-nd Critical Care Explorations 2023-01-01

We hypothesized that transcutaneous gas determinations of O2 and CO2 (TcPO2 TcPCO2 ) are associated with the severity PAH.In this cross-sectional study, we included consecutive patients PAH (group 1 PH; n = 34). Transcutaneous were compared to those age- gender-matched healthy controls (n 14), nongroup PH 19) or high estimated RVSP on echocardiography but without hemodynamic evidence 12).In PAH, TcPO2 , significantly PaO2 (R 0.44, p 0.03) PaCO2 0.77, < 0.001), respectively. /FiO2 (mean...

10.1111/micc.12191 article EN Microcirculation 2015-01-31

Subcutaneous implantable cardioverter defibrillators (S-ICDs) are an attractive alternative to transvenous ICDs among those not requiring pacing. However, the risks of damage S-ICD electrode during sternotomy and adverse interactions with sternal wires remain unclear. We sought determine rates lead sternotomy, inappropriate shocks from electrical noise due interaction wires, failure terminate spontaneous or induced ventricular arrhythmias.Retrospective, multicenter study patients undergoing...

10.1161/circep.123.011867 article EN mit Circulation Arrhythmia and Electrophysiology 2023-07-24

Introduction: Pulmonaryhypertension (PH) is a common complication of idiopathic pulmonary fibrosis (IPF) that associated with poor prognosis. Screening for PH in IPF patients proves to be challenging. Hypothesis: We hypothesized combining several non-invasive studies can predict the presence patients. Methods: included 235 who underwent right heart catheterization (RHC) as part lung transplant evaluation. measured ECG and echocardiographic variables well artery (PA) diameter ascending aorta...

10.1161/circ.132.suppl_3.12336 article EN Circulation 2015-11-10

Radiofrequency (RF) ablation can be a source of electromagnetic interference (EMI) for cardiovascular implantable electronic devices (CIEDs). The response CIEDs to this type EMI variable and unpredictable. We report case with an uncommon where there was failure deliver pacing pulses both atrial ventricular leads during RF close the lead even when pacemaker set pace asynchronously. also explain mechanism behind unusual response.

10.19102/icrm.2023.14073 article EN Journal of Innovations in Cardiac Rhythm Management 2023-07-01

CLOVES syndrome (Congenital Lipomatous Overgrowth, Vascular malformations, and Epidermal nevi) is a rare recently discovered syndrome. It associated with vascular malformations abnormal fatty tissue skeletal growth. In this case, we report the clinical manifestations overtime in patient who presented unique arteriovenous malformation that led to severe neurological impairment by compressing spinal cord. We also discuss visceral findings our patient, such as double ureter splenomegaly,...

10.4172/2572-5130.1000135 article EN cc-by Medical Reports & Case Studies 2017-01-01

CLOVES syndrome (Congenital Lipomatous Overgrowth, Vascular malformations, and Epidermal nevi) is a rare recently discovered syndrome. It associated with vascular malformations abnormal fatty tissue skeletal growth. In this case, we report the clinical manifestations overtime in patient who presented unique arteriovenous malformation that led to severe neurological impairment by compressing spinal cord. We also discuss visceral findings our patient, such as double ureter splenomegaly,...

10.12691/ajmcr-5-6-7 article EN American Journal of Medical Case Reports 2017-07-13
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