A5051837765- Systemic Lupus Erythematosus Research
- Mesenchymal stem cell research
- Salivary Gland Disorders and Functions
- Reproductive System and Pregnancy
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
- Immune cells in cancer
- Immune Cell Function and Interaction
- Bone and Joint Diseases
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal Diseases and Glomerulopathies
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Blood groups and transfusion
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Hormonal and reproductive studies
- Salivary Gland Tumors Diagnosis and Treatment
- Nuclear Receptors and Signaling
- Psoriasis: Treatment and Pathogenesis
- Galectins and Cancer Biology
- Retinal Diseases and Treatments
- Systemic Sclerosis and Related Diseases
- Erythrocyte Function and Pathophysiology
Nanjing Drum Tower Hospital
2016-2025
Nanjing University of Chinese Medicine
2022-2025
Shenzhen Second People's Hospital
2025
Shenzhen University Health Science Center
2025
Nanjing Medical University
2003-2025
Nanjing University
2005-2023
North China Electric Power University
2023
China Electric Power Research Institute
2023
Model Animal Research Center
2020
Philippine General Hospital
2016
Enterovirus 71 (EV71) is one of the major causative agents outbreaks hand, foot, and mouth disease or herpangina worldwide. This phase 3 trial was designed to evaluate efficacy, safety, immunogenicity an EV71 vaccine.We conducted a randomized, double-blind, placebo-controlled, multicenter in which 10,007 healthy infants young children (6 35 months age) were randomly assigned 1:1 ratio receive two intramuscular doses either vaccine placebo, 28 days apart. The surveillance period 12 months....
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, which, despite the advances in immunosuppressive medical therapies, remains potentially fatal some patients, especially treatment-refractory patients. This study found that transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) has same therapeutic effect as bone marrow (BM-MSCs), which been reported to be efficient treating SLE-related symptoms MRL/lpr mice. Multi-treatment (at 18th, 19th, and 20th weeks...
Abstract Neuropsychiatric lupus (NPSLE) is a frequent manifestation of systemic erythematosus (SLE) that occurs in 40–90% SLE patients; however, the underlying mechanisms remain elusive, causing severe lack therapeutic targets for this condition. Here, we show complement-coordinated elimination synapses participated NPSLE MRL/lpr mice, lupus-prone murine model. We demonstrated mice developed increased anxiety-like behaviors and persistent phagocytic microglial reactivation before overt...
Disturbed lipid metabolism was observed in systemic lupus erythematosus (SLE) patients. This study aimed to evaluate the relationships between dyslipidemia and visceral organ involvement, disease severity, inflammatory factors, drug intake SLE patients.Inpatients with (n = 105) healthy controls (HC) 75) were recruited this study. Clinical laboratory data collected from patient records. The concentrations of tumor necrosis factor receptors superfamily member1A (TNFRSF1A), member1B (TNFRSF1B)...
Rationale: Although mesenchymal stem cell (MSC) transplantation has been proved to be an effective therapeutic approach treat experimental Sjögren's syndrome (SS), the detailed underlying mechanisms remains unknown. IL-27 diverse influences on regulation of T differentiation and was involved in SS through modulating immune response. Here we aimed explore whether IL-27-mediated cells responsible for beneficial effects MSC SS. Methods: The SS-like symptoms were evaluated deficient recombinant...
Mesenchymal stem cells (MSCs) have been demonstrated to be effective in treating autoimmune diseases including Sjögren's syndrome (SS). We aim compare the effects of MSC transplantation (MSCT) and role serum interleukin-12 (IL-12) SS. IL-12 levels were measured by ELISA. mRNA transcripts dendritic (DCs) determined RT-PCR. After co-culturing with MSCs, mouse human DCs detected. Non-obese diabetic (NOD) mice received MSCT, recombinant IL-12, or anti-IL-12 mAb treatment, respectively. Then,...
Mesenchymal stem cells (MSCs) possess multipotent and immunomodulatory properties are suggested to be involved in the pathogenesis of immune-related diseases. This study explored function bone marrow MSCs from rheumatoid arthritis (RA) patients, focusing on effects. RA showed decreased proliferative activity aberrant migration capacity. No significant differences were observed cytokine profiles between control MSCs. The effects proliferation peripheral blood mononuclear (PBMCs) distribution...
Lipocalin-2 (LCN2) is an indicator of the severity lupus nephritis (LN) and plays a pivotal role in immune responses, but it not known if its effect on LN pathogenesis derives from regulating imbalance T lymphocyte subsets.The expression LCN2 cells kidneys was assessed renal biopsies patients with LN. We investigated relationship between levels development systemic illness by injecting anti-LCN2 antibodies into MRL/lpr mice analyzing pristane-treated LCN2-/- mice.LCN2 highly expressed CD4+...
The aberrant generation or activation of T follicular helper (Tfh) cells contributes to the pathogenesis systemic lupus erythematosus (SLE), yet little is known about how these are regulated. In this study, we demonstrated that frequency Tfh was increased in lupus-prone B6.MRL-Faslpr (B6.lpr) mice and positively correlated plasma cell proportions serum total IgG as well anti-dsDNA antibody levels. Transplantation mesenchymal stem derived from Wharton's jelly human umbilical cords (hUC-MSCs)...
<b><i>Background:</i></b> Evidence has accumulated that hypoxia plays a significant role in the pathogenesis and progression of both acute renal injury chronic disease. However, little was known about effects on lupus nephritis (LN). In current study, we investigated expression inducible factor-1 alpha (HIF-1α) LN. <b><i>Methods:</i></b> Renal biopsies from 22 LN patients 20 with carcinoma were obtained. situ HIF-1α examined by...
Podocyte injury plays a pathogenic role in the development of lupus nephritis (LN). Mesenchymal stem cells (MSCs) have shown promising therapeutic potential for LN. However, whether MSCs can prevent podocyte LN remains unknown. Human umbilical cord-derived (UC-MSCs) were infused into lupus-prone B6.MRL-Faslpr (B6.lpr) mice to investigate influences UC-MSCs on Podocytes and macrophages co-cultured with vitro study mechanism by which UC-MSC protect podocytes. We further explored effects...
Mesenchymal stem cells (MSCs) play an anti-inflammatory role by secreting certain bioactive molecules to exert their therapeutic effects for disease treatment. However, the underlying mechanism of MSCs in chronic autoimmune liver diseases—primary biliary cholangitis (PBC), example—remains be elucidated. Human umbilical cord–derived (UC-MSCs) were injected intravenously into 2-octynoic acid coupled bovine serum albumin (2OA-BSA)-induced mice. Serum levels biomarkers and autoantibodies,...