A5101752824- Nutritional Studies and Diet
- Sodium Intake and Health
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Diabetes Management and Research
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
- Healthcare and Venom Research
- Hepatitis B Virus Studies
- Pancreatic function and diabetes
- Pediatric Hepatobiliary Diseases and Treatments
- Bipolar Disorder and Treatment
- Medical Imaging and Analysis
- Nuclear Receptors and Signaling
- Schizophrenia research and treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ovarian function and disorders
- Spinal Fractures and Fixation Techniques
- Respiratory viral infections research
- Spine and Intervertebral Disc Pathology
- COVID-19 Clinical Research Studies
- Acupuncture Treatment Research Studies
- Potassium and Related Disorders
Beijing Anzhen Hospital
2025
Capital Medical University
2025
First Affiliated Hospital Zhejiang University
2020-2024
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
Kunming Medical University
2023
Zhejiang University
2014-2022
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2022
Nanfang Hospital
2022
Southern Medical University
2022
Abstract Background Effective antiviral drugs for COVID-19 are still lacking. This study aims to evaluate the clinical outcomes and plasma concentrations of baloxavir marboxil favipiravir in patients. Methods Favipiravir acid were evaluated their activity against SARS-CoV-2 vitro before trial initiation. We conducted an exploratory with 3 arms involving hospitalized adult patients COVID-19. Patients randomized assigned a 1:1:1 ratio into group, control group. The primary outcome was...
The spot urine method as an alternative approach in estimating daily sodium excretion has been proposed for many years. Kawasaki created equation to predict urinary using second morning (SMU) samples which was obtained before breakfast after initial voiding upon arising. Tanaka developed another by examining submitted at random times during the day. A newly published study that “PM sample,” collected late afternoon or early evening dinner, showed a stronger relationship with actual...
ABSTRACT Entecavir (ETV) is a first-line antiviral agent for the treatment of chronic hepatitis B virus infection. Renal excretion major elimination path ETV, in which tubular secretion plays key role. However, mechanism has not been clarified. We speculated that renal transporters mediated ETV. Therefore, aim our study was to elucidate contribute disposition Our results revealed ETV (50 μM) remarkably reduced accumulation probe substrates MDCK cells stably expressing human multidrug and...
The aim of this study was to investigate the effects simvastatin on insulin secretion in mouse MIN6 cells and possible mechanism. were, respectively, treated with 0 μ M, 2 5 10 M for 48 h. Radio immunoassay performed measure effect cells. Luciferase method used examine content ATP Real-time PCR western blotting were mRNA protein levels inward rectifier potassium channel 6.2 (Kir6.2), voltage-dependent calcium 1.2<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo...
Nitidine chloride (NC), a quaternary ammonium alkaloid, has numerous pharmacological effects, such as anticancer activity. However, it was found that NC also hepatocellular toxicity. Because organic cation transporters 1 and 3 (OCT1 OCT3) might mediate the influx of into hepatocytes, multidrug toxin extrusion (MATE1) probably mediates efflux from while cytochrome P450 (P450) enzymes contribute to metabolism, present study evaluate contribution OCT1, OCT3, MATE1, NC-induced Our results showed...
The overweight and obese population experiences a higher occurrence of both hyperuricemia metabolic syndrome. present study was to explore the relationship between serum uric acid syndrome-related risk factors among 409 Chinese adults (254 women 155 men) with >24 kg/m2 BMI. Based on sex-specific reference ranges, 233 (57%) patients showed elevated acid. A total 15 attributes were selected assess associations components syndrome, including acid, cholesterol, HDL-C, LDL-C, triglyceride,...
Entecavir (ETV), a nucleoside analog with high efficacy against hepatitis B virus, is recommended as first-line antiviral drug for the treatment of chronic B. However, scant information available on use ETV in pregnancy. To better understand safety pregnant women, we aimed to demonstrate whether could permeate placental barrier and underlying mechanism. Our study showed that small amount across placenta mice. accumulation activated or nonactivated BeWo cells (treated without forskolin) was...
The incidence of type 2 diabetes is increasing worldwide. Hepatic insulin resistance and liver lipid accumulation contributes to development. aim the present study was investigate key gene pathways co-expression networks in livers patients.Dataset GSE15653 containing nine healthy individuals patients downloaded from National Center for Biotechnology Information Gene Expression Omnibus database. Differentially expressed genes were obtained patients, annotated pathway enrichment...
Use of K-means clustering for big data technology to cluster an overweight and obese population metabolically.K-means with the help quantile transformation attribute values was applied overcome impact considerable variation in obesity attributes involving outliers skewed distribution.Overall, 447 subjects were categorized into six clusters; metabolically normal, mild, severe categories. There clearly separated normal Cluster 1 2, as well intermediate 3, 4, 5 that had profiles fewer abnormal...
To examine the optimal cut-off values of visceral fat area (VFA) for predicting metabolic syndrome (MetS) among type 2 diabetes (T2D) patients in Ningbo China.A total 1017 subjects were selected from T2D who accepted standardized management by National Standardized Metabolic Disease Management Center at First Hospital March 2018 to January 2020. Demography and medical information collected through questionnaires. Regional adiposity was examined a analyzer using dual bioelectrical impedance...
Hand-foot syndrome (HFS) is a major adverse reaction to capecitabine (CAP). The exact pathogenesis of this disease remains unclear. In study, metabolomics combined with cell RNA sequencing was used study the mechanisms CAP-induced HFS. murine model HFS constructed by intragastric administration CAP or its metabolites. Quantitative reverse transcription polymerase chain and enzyme-linked immunosorbent assays were verify mechanisms. Metabolomics showed phosphatidylinositol signaling pathway...
Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on association between dietary salt intake and glycemic response T2D are lacking The aim was to investigate levels plasma glucose, insulin hemoglobin A1c (HbA1c) patients.Patients with T2D, who accepted management treatment by National Standardized Metabolic Disease Management Center at Ningbo First Hospital from March 2018 January 2020, were included this study. Dietary assessed through a standardized food...
Goal progress logging and social feedback have been shown to motivate individuals achieve their goals. However, little controlled study has done evaluate the relative effects of these features. We developed a simple goal achievement application, Achieve, examine on completion. Results an in-progress suggest that both had positive surprisingly, no significant advantage over logging. Further, participants who gave received higher level annoyance toward study. discuss possible reasons for this...
Insufficient insulin release plays a crucial role in the development of unhealthy status patients with obesity; present study aimed to classify these by indices for resistance and release. After from OGTT were assessed achieve high differentiability low redundancy classifying patients, HOMA-IR IGI30min chosen using K-means clustering method. A total 249 non-diabetic obesity classified into four groups. In Group 1, 19 characteristic release, as well well-controlled glucose levels, highest...
Background: Few comprehensive lifestyle intervention programmes have been investigated on overweight and obese adults in China. This study was to evaluate the effect of a 36-month weight management programme loss its maintenance among patients Ningbo, Methods: Adults with BMI ≥24kg/m 2 enrolled this programme, including nutritional, physical activity, psychological endocrinological counselling sessions, from July 2015 January 2020. participated face-to-face sessions group-based education....