A5103002166- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Infective Endocarditis Diagnosis and Management
- Cardiac tumors and thrombi
- Gout, Hyperuricemia, Uric Acid
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Coronary Interventions and Diagnostics
- Protease and Inhibitor Mechanisms
- Sirtuins and Resveratrol in Medicine
- Traditional Chinese Medicine Analysis
- Protein Tyrosine Phosphatases
- Cardiovascular Function and Risk Factors
- Pharmacological Effects of Natural Compounds
- Inflammasome and immune disorders
- Caveolin-1 and cellular processes
- Aortic Thrombus and Embolism
- Coronary Artery Anomalies
- Galectins and Cancer Biology
- Eicosanoids and Hypertension Pharmacology
- Erythrocyte Function and Pathophysiology
- Alcoholism and Thiamine Deficiency
- Electrospun Nanofibers in Biomedical Applications
Ministry of Education of the People's Republic of China
2021-2025
Southern Medical University
2019-2025
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2021-2025
Nanfang Hospital
2019-2025
Hemodynamic overload and dysregulation of cellular metabolism are involved in development calcific aortic valve disease (CAVD). However, how mechanical stress relates to metabolic changes CAVD remains unclear. Here, we show that Piezo1, a mechanosensitive ion channel, regulated glutaminase 1 (GLS1)-mediated glutaminolysis promote osteogenic differentiation interstitial cells (VICs). In vivo, two models stenosis were constructed by ascending constriction (AAC) direct wire injury (DWI)....
Abstract Aims Calcific aortic valve disease (CAVD) has become an increasingly important global medical problem without effective pharmacological intervention. Accumulating evidence indicates that calcification is driven by inflammation. Interleukin-1 receptor-associated kinase M (IRAK-M) a well-known negative regulator of inflammation, but its role in CAVD remains unclear. Methods and Results Here, we stimulated interstitial cells (AVICs) with low-dose lipopolysaccharide (LPS) to mimic the...
Abstract Aims Recent studies have shown that the choline-derived metabolite trimethylamine N-oxide (TMAO) is a biomarker promotes cardiovascular disease through induction of inflammation and stress. Inflammatory responses stress are involved in progression calcified aortic valve (CAVD). Here, we examined whether TMAO induces osteogenic differentiation interstitial cells (AVICs) endoplasmic reticulum (ER) mitochondrial pathways vitro vivo. Methods results Plasma levels were higher patients...
Abstract Background Calcific aortic valve disease (CAVD) is the most prevalent valvular and has high morbidity mortality. CAVD characterized by complex pathophysiological processes, including inflammation-induced osteoblastic differentiation in interstitial cells (AVICs). Novel anti-CAVD agents are urgently needed. Protein tyrosine phosphatase nonreceptor type 22 (PTPN22), an intracellular nonreceptor-like protein phosphatase, involved several chronic inflammatory diseases, rheumatoid...
No effective therapeutic agents for calcific aortic valve disease (CAVD) are available currently. Dietary supplementation has been proposed as a novel treatment modality various diseases. As flavanone, hesperetin is widely abundant in citrus fruits and proven to exert protective effects multiple However, the role of CAVD remains unclear.Human interstitial cells (VICs) were isolated from leaflets. A mouse model stenosis was constructed by direct wire injury (DWI). Immunoblotting,...
Background and Objective: Calcific aortic valve disease (CAVD) is a debilitating condition characterized by excessive oxidative stress inflammation. Trimethylamine N-oxide (TMAO), gut microbiota-derived metabolite, has been implicated in CAVD pathogenesis. Lysine-specific demethylase 2B (KDM2B) possesses antioxidant properties. This study aimed to investigate the protective role of KDM2B against TMAO-mediated explores underlying mechanisms. We hypothesized that mitigates TMAO-induced...
Calcific aortic valve disease (CAVD) is a valvular frequently in the elderly individuals that can lead to dysfunction. Osteoblastic differentiation of human interstitial cells (HAVICs) induced by inflammation play crucial role CAVD pathophysiological processes. To date, no effective drugs for have been established, and new agents are urgently needed. Piericidin glycosides, obtained from marine-derived Streptomyces strain, were revealed regulatory effects on mitochondria previous studies....
Background: Calcific aortic valve disease (CAVD) has become an increasingly important global medical problem, but effective pharmacological interventions are not available. CircRNAs, a type of noncoding RNA, play critical role in the progression cardiovascular disease. However, relationship between circRNAs and CAVD still needs to be explored.Methods: CircRNA expression profiles human calcified non-calcified valves were obtained by high-throughput sequencing, circRNA associated with was...
Background: The gut microbe-derived metabolite trimethylamine-N-oxide(TMAO) has been implicated in the development of cardiovascular fibrosis. Recent reports have suggested that activation PERK/ATF-4 and IRE-1α/XBP-1s signaling contributes to However, whether TMAO mediates aortic valve fibrosis by activating remains unclear.Methods Results: Human interstitial cells (AVICs) were isolated from leaflets. ATF-4, IRE-1α, XBP-1s CHOP activation, production collagen I TGF-β1 analyzed following...
Background: Calcific aortic valve disease (CAVD) has become an increasingly important global medical problem without effective pharmacological intervention. Based on accumulating evidence, calcification is inflammation-dependent process. It well known that interleukin-1 receptor associated kinase M (IRAK-M) a negative regulator of inflammation, but its role in CAVD unclear.Methods: Here, we treated interstitial cells (AVICs) with lipopolysaccharide (LPS) to observe the expression pattern...
Background: No effective therapeutic agents for calcific aortic valve disease (CAVD) are available. Dietary therapy has been proposed as a novel treatment strategy various diseases. As flavanone, class of flavonoids, hesperetin is widely abundant in citrus fruits and proven to play protective role against multiple However, the CAVD remains unclear.Methods: Human interstitial cells (VICs) were isolated from leaflets. A mouse model stenosis was constructed by direct wire injury (DWI). The...
To investigate the optimal time window for observation of catheter-induced valve injury that mimics calcified aortic disease in mice.A catheter was inserted into right common carotid artery 8-week-old C57BL6 mice under ultrasound guidance, and induced using guide wire.At 4, 8 16 weeks after modeling, were subjected to measurement heart short axial shortening rate, peak velocity orifice area.Grain-Eosin staining used observe changes thickness valve, calcium deposition assessed Alizarin red...