A5090284314- Autophagy in Disease and Therapy
- Cardiac Valve Diseases and Treatments
- Pharmacological Effects of Natural Compounds
- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Probiotics and Fermented Foods
- Metabolism and Genetic Disorders
- Gut microbiota and health
- Blood Pressure and Hypertension Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Hormonal Regulation and Hypertension
- Aortic Thrombus and Embolism
- GDF15 and Related Biomarkers
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cardiac Structural Anomalies and Repair
- ATP Synthase and ATPases Research
- Diet and metabolism studies
- Iron Metabolism and Disorders
- Traditional Chinese Medicine Analysis
Ministry of Education of the People's Republic of China
2019-2024
Southern Medical University
2016-2022
Nanfang Hospital
2017-2021
Abstract Background In heart failure (HF), mitochondrial dysfunction and metabolic remodeling lead to a reduction in energy productivity aggravate cardiomyocyte injury. Supplementation with α-ketoglutarate (AKG) alleviated myocardial hypertrophy fibrosis mice HF improved cardiac insufficiency. However, the protective mechanism of AKG remains unclear. We verified hypothesis that improves function by upregulating NAD + levels activating silent information regulator 2 homolog 1 (SIRT1)...
Mitochondrial dynamics play a critical role in mitochondrial function. The mitofusin 2 (MFN2) gene encodes membrane protein that participates fusion to maintain and operate the network. Moreover, MFN2 is essential for mitophagy. In Ang II-induced cardiac remodeling, combined effects of MFN2-mediated mitophagy are unclear. This study was designed explore novel strategy preventing cardiomyocyte injury via modulation dynamics.We studied function II-stimulated injury. Cardiomyocyte experiments,...
Increasing evidence indicates the involvement of myocardial oxidative injury and mitochondrial dysfunction in pathophysiology heart failure (HF). Alpha-ketoglutarate (AKG) is an intermediate metabolite tricarboxylic acid (TCA) cycle that participates different cellular metabolic regulatory pathways. The circulating concentration AKG was found to decrease with ageing elevated after acute exercise resistance HF. Recent studies experimental models have shown dietary reduces reactive oxygen...
Ferulic acid, a main ingredient of Ligusticum, exhibits anti-oxidant and anti-inflammation effects in heart diseases. Some studies indicate that gut microbiome is associated with the generation ferulic acid. Whether beneficial effect raised by alteration microbiota still unknown. This study examined sodium ferulate on cardiac function TAC mice. Cell Counting Kit-8 (CCK8) assay verified acid has low toxicity vitro inhibited up-regulation β-MHC ANP induced Angiotensin II. In addition, daily...
BACKGROUND Cardiac rupture often occurs after acute myocardial infarction due to complex and unclear pathogenesis. This study investigated whether metformin increases the incidence of cardiac through AMPK-MTOR/PGC-1α signaling pathway. MATERIAL AND METHODS An (MI) mouse model was established. A series experiments involving RT-qPCR, Western blot, TUNEL staining, Masson staining were performed in this study. RESULTS Myocardial occurred, resulting rupture, expression level PGC-1α increased...
Objective: To compare the clinical characteristics, and outcomes of patients with heart failure different left ventricular ejection fractions (LVEF). Methods: A total 1 182 hospitalized (HF) were enrolled retrospectively studied in present study. The stratified by LVEF as reduced (HFrEF, LVEF<40%, n=313), mid-range (HFmrEF, 40% ≤LVEF <50%, n=287) preserved (HFpEF, LVEF≥50%, n=582) fraction groups. Among cases, 941 them (81.3%, 84.9%, 84.0% inHFrEF, HFmrEF HFpEF groups, respectively) followed...
Chronic heart failure (CHF) is a major public health burden and associated with high morbidity, mortality, cost. Recent studies demonstrated iron metabolism myocardial energy were altered in CHF patients. In this study, we aimed to analyze the effects correlations of on CHF.One hundred thirty patients [age: 66.2±11.5 years, males: 58.5% New York Heart Association (NYHA) class (II/III/IV): 67/43/20] included. Serum concentrations ferritin, transferrin saturation (Tsat), soluble receptor...
Background: No effective therapeutic agents for calcific aortic valve disease (CAVD) are available. Dietary therapy has been proposed as a novel treatment strategy various diseases. As flavanone, class of flavonoids, hesperetin is widely abundant in citrus fruits and proven to play protective role against multiple However, the CAVD remains unclear.Methods: Human interstitial cells (VICs) were isolated from leaflets. A mouse model stenosis was constructed by direct wire injury (DWI). The...