A5101985976- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Sesquiterpenes and Asteraceae Studies
- Muscle Physiology and Disorders
- Natural product bioactivities and synthesis
- Neurogenetic and Muscular Disorders Research
- Polysaccharides and Plant Cell Walls
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Urticaria and Related Conditions
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Mast cells and histamine
- Traditional Chinese Medicine Analysis
- Environmental Sustainability in Business
- Flood Risk Assessment and Management
- Sustainable Supply Chain Management
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- Phytochemical compounds biological activities
- Exercise and Physiological Responses
- Plant biochemistry and biosynthesis
Shanghai Institute of Materia Medica
2021-2025
Chinese Academy of Sciences
2017-2025
Shandong Academy of Sciences
2025
Qilu University of Technology
2025
University of Chinese Academy of Sciences
2020-2025
Zero to Three
2025
Sichuan Mianyang 404 Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Peking Union Medical College Hospital
2025
Heilongjiang University of Chinese Medicine
2024
The molecular mechanisms underlying denervated skeletal muscle atrophy with concomitant mass loss have not been fully elucidated. Therefore, this study aimed to attain a deeper understanding of the as critical step developing targeted therapy and retarding mass.We employed microarray analysis reveal potential atrophy. We used in vitro vivo models explore roles interleukin 6 (IL-6), Janus kinase (JAK), signal transducers activators transcription 3 (STAT3) atrophy.In study, differentially...
Disialosyl globopentaosylceramide (DSGb5) is a tumor-associated complex glycosphingolipid. However, the accessibility of structurally well-defined DSGb5 for precise biological functional studies remains challenging. Herein, we describe first total synthesis glycolipid by an efficient chemoenzymatic approach. A Gb5 pentasaccharide-sphingosine was chemically synthesized convergent and stereocontrolled [2 + 3] method using oxazoline disaccharide donor to exclusively form β-anomeric linkage....
Although denervated muscle atrophy is common, the underlying molecular mechanism remains unelucidated. We have previously found that oxidative stress and inflammatory response may be early events trigger atrophy. Isoquercitrin a biologically active flavonoid with antioxidative anti-inflammatory properties. The present study investigated effect of isoquercitrin on its possible mechanisms. was effective in alleviating mass loss following denervation dose-dependent manner. demonstrated optimal...
Skeletal muscle atrophy involves and requires widespread changes in skeletal gene expression signaling pathway, resulting excessive loss of mass strength, which is associated with poor prognosis the decline life quality several diseases. However, treatment remains an unresolved challenge to this day. The aim present study was investigate influence pyrroloquinoline quinone (PQQ), a redox-active o-quinone found various foods mammalian tissues, on atrophy, explore underlying molecular...
High-fat consumption promotes the development of obesity, which is associated with various chronic illnesses. Mitochondria are energy factories eukaryotic cells, maintaining self-stability through a fine-tuned quality-control network. In present study, we evaluated high-fat diet (HFD)-induced changes in mitochondrial ultrastructure and dynamics protein expression multiple organs. C57BL/6J male mice were fed HFD or normal (ND) for 24 weeks. Compared ND-fed mice, HFD-fed exhibited increased...
Comprehensive Summary 17 new guaiane‐type sesquiterpenoid dimers (GSDs), artemzhongdianolides B1—B17 ( 1 — ), were isolated from Artemisia zhongdianensis under the guidance of bioassay, and elucidated by spectral analyses (HRESIMS, 1D 2D NMR, IR, ECD). The absolute configuration compounds , 3 7 9 10 13 was determined single‐crystal X‐ray diffraction analyses. Structurally, B1 ) B2 2 first example GSDs fused via a C‐13/C‐13' single bond, B3—B17 [4 + 2] Diels–Alder adducts two monomeric...
Septic shock comprises a heterogeneous population, and individualized resuscitation strategy is of vital importance. The study aimed to identify subclasses septic with non-supervised learning algorithms, so as tailor for each class.Patients in 25 tertiary care teaching hospitals China from January 2016 December 2017 were enrolled the study. Clinical laboratory variables collected on days 0, 1, 2, 3 7 after ICU admission. Subclasses identified by both finite mixture modeling K-means...
Bioactive polysaccharides from natural resources target various biological processes and are increasingly used as potential molecules for drug development. However, the accessibility of branched long complex polysaccharide active domains with well-defined structures remains a major challenge. Herein we describe an efficient first total synthesis highly heptadecasaccharide moiety native bioactive galectin-3-targeting Carthamus tinctorius L. well shorter fragments heptadecasaccharide. The key...
The σ/π-binding properties of a series Lewis acids was studied using DFT calculations. results led to the identification Zn(II)/In(III) as suitable dual-mode acid for use in promoting cascade cyclization reactions. Based on this finding, we developed three new types induced reactions and have demonstrated utilities each process natural product synthesis. 1 Introduction 2 Dual-Mode Acids 3 Prins/Conia-Ene Cascade Reaction its Applications 4 Diels–Alder/Carbocyclization 4.1 First Generation...
Combination chemotherapy is a potentially promising approach to enhance anticancer activity, overcome drug resistance, and improve disease-free overall survival. The current study investigates the antitumor activity of sodium dichloroacetic acid (DCA) in combination with SIRT2 inhibitor Sirtinol AGK2. We found that combining DCA produced synergistic therapeutic benefit A549 H1299 NSCLC cells vitro mouse xenograft model. Synergistic potentiation oxidative phosphorylation (OXPHOS) was...
Skeletal muscle atrophy, characterized by accelerated protein degradation, occurs in such conditions as unloading, immobilization, fasting, and denervation. Effective treatments for skeletal atrophy are not yet available. Considering that microRNAs (miRs) may play an important role the regulation of present study, we aimed to examine effect miR-125b-5p-based therapeutic strategies on explore underlying mechanisms.Fasting-induced atrophic mouse C2C12 myotubes denervated rat tibialis anterior...
Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive atrophy. At present, there is no effective treatment for Histone deacetylase 4 (HDAC4) has recently been found be closely related atrophy, but underlying mechanism of HDAC4 denervation-induced atrophy have not described clearly yet. In this study, we that expression increased significantly denervated muscle. inhibition effectively diminish reduce specific E3 ubiquitin ligase (MuRF1 MAFbx) autophagy...
Abstract Pyruvate kinase M2 (PKM2), which is predominantly expressed in most cancers, plays a key role the Warburg effect. However, how PKM2 functions as tumor supportive protein has not been fully elucidated. Here, we identified tristetraprolin (TTP), an AU-rich, element-binding that regulates mRNA stability, new binding partner of PKM2. Our data reveal suppresses TTP levels by promoting its phosphorylation, ubiquitination and proteasome degradation, reducing turnover ability ultimately...
Glycosylation of proteins is a complicated post-translational modification. Despite the significant progress in glycoproteomics, accurate functions glycoproteins are still ambiguous owing to difficulty obtaining homogeneous glycopeptides or glycoproteins. Here, we describe streamlined chemoenzymatic method prepare complex by integrating hydrophobic tag-supported chemical synthesis and enzymatic glycosylations. The tag utilized facilitate peptide chain elongation liquid phase expeditious...
Comprehensive Summary Artemiprincepsolides A—F ( 1 — 6 ) were isolated from Artemisia princeps guided by bioactivity and elucidated comprehensive spectral data ECD calculation. Compounds 3 represented the first connecting model of germacrane‐guaiane hetero‐dimeric adducts, compounds 4 eudesmane‐guaiane hetero‐coupled sesquiterpenoid dimers, meanwhile, all these presumably formed Diels‐Alder cycloaddition. evaluated for their hepatomatic cytotoxicity on three hepatoma cell lines, demonstrated...
α-Galactosylceramide (KRN7000 or α-GalCer) analogues terminated with phenyl (Ph) groups at the acyl moiety possess more potency than KRN7000 to activate invariant natural killer T (iNKT) cells for inducing a helper 1 (Th1)-biased immune response. However, biological activities of glycolipids thio-modifications remain unknown, and facile approaches highly stereoselective synthesis its are rather scarce. Herein, we exploited 4,6-di-
Cancer stem cells (CSCs) contribute to the cancer initiation, metastasis and drug resistance in non-small cell lung (NSCLC). Herein, we identified a miR-221/222 cluster as novel regulator of CSCs NSCLC. Targeted overexpression or knockdown NSCLC revealed essential roles regulation proliferation, mammosphere formation, subpopulation CD133 + expression stemness genes including OCT4, NANOG h-TERT. The vivo animal study showed that significantly enhanced capacity develop tumor grow faster,...