A5100409502- Phonetics and Phonology Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurobiology of Language and Bilingualism
- Cancer Genomics and Diagnostics
- Language Development and Disorders
- Color perception and design
- Reading and Literacy Development
- Prostate Cancer Treatment and Research
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Obsessive-Compulsive Spectrum Disorders
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- TiO2 Photocatalysis and Solar Cells
- Cancer-related molecular mechanisms research
- Advanced Text Analysis Techniques
- Child and Adolescent Psychosocial and Emotional Development
- Cancer Mechanisms and Therapy
- Color Science and Applications
- Sentiment Analysis and Opinion Mining
- Advanced Photocatalysis Techniques
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Eating Disorders and Behaviors
Tianjin Medical University General Hospital
2025
Xihua University
2023-2024
Nanjing University of Chinese Medicine
2024
University of Jyväskylä
2024
Sichuan Normal University
2024
Shanghai Jiao Tong University
2014-2023
Renji Hospital
2015-2023
Fujian Agriculture and Forestry University
2023
Shanghai Mental Health Center
2017-2022
East China Normal University
2021
BackgroundPancreatic cancer (PC) is one of the most lethal solid malignancies in world due to its excessive cell proliferation and aggressive metastatic features. Emerging evidences revealed importance posttranscriptional modifications RNAs PC progression. However, knowledge about 5-methylcytosine (m5C) RNA modification still extremely limited. In this study, we attempted explore expression changes clinical significances 12 known m5C-related genes among patients.MethodsA total 362 normal 382...
Self-construal priming modulates human behavior and associated neural activity. However, the activity with self-construal procedure itself remains unknown. It is also unclear whether how affects prior to engaging in a particular task. To address this gap, we scanned Chinese adults, using functional magnetic resonance imaging, during following resting state. We found that, relative calculation task, both interdependent independent activated ventral medial prefrontal cortex (MPFC) posterior...
Abstract Background and Aim To develop validate radiomic prediction models using contrast‐enhanced computed tomography (CE‐CT) to preoperatively predict Ki‐67 expression in gastrointestinal stromal tumors (GISTs). Method A total of 339 GIST patients from four centers were categorized into the training, internal validation, external validation cohort. By filtering unstable features, minimum redundancy, maximum relevance, Least Absolute Shrinkage Selection Operator (LASSO) algorithm, a...
Recurrent implantation failure (RIF) is a challenging problem of assisted reproductive technology that arises mainly due to inadequate endometrial receptivity and its pathogenesis still unclear.In this study, we conducted the first investigation effect decreased PIBF1 expression in mid-secretory phase on patients with RIF.Microarray assay, reverse transcriptase-quantitative polymerase chain reaction, western blot, in-vitro experiments were conducted.The results showed progesterone-induced...
Abstract Donor-derived cell-free DNA (dd-cfDNA) has been of major interest recently as a non-invasive marker graft injury, but not yet extensively tested in children. From May to September 2019, total 76 pediatric patients receiving liver were enrolled and there 27 excluded. Ultimately plasma samples matched specimens from 49 successfully collected whenever rejection was suspected clinically. Dd-cfDNA analyzed then compared biopsy. Of these, 11 (22.4%) found have by levels higher among with...
The highly malignant feature and difficulties for early diagnosis are the key reasons contributing to poor prognosis of pancreatic cancer (PC) patients. NFE2L3 is a nuclear transcription factor, which has been reported an important biomarker several tumors. But role in PC remained undefined. Herein, through qPCR immunohistochemistry, we found significantly increased tissues as compared with adjacent non-tumor tissues. While reducing expression suppressed invasion abilities cells, elevated...
Abstract Background Gallbladder carcinoma is highly aggressive and resistant to chemotherapy, with no consistent strategy guide first line chemotherapy. However, patient‐derived xenograft (PDX) model has been increasingly used as an effective for in preclinical study of chemosensitivity. Methods Mini‐PDX was established using freshly resected primary lesions from 12 patients gallbladder examine the sensitivity five most commonly chemotherapeutic agents, namely gemcitabine, oxaliplatin,...
Newborns exhibit a heightened vulnerability to inflammatory disorders due their underdeveloped immune system, yet the underlying mechanisms remain poorly understood. Here we report that plasma spermidine is correlated with maturity of human newborns and reduced risk inflammation. Administration led remission neonatal inflammation in mice. Mechanistic studies revealed enhanced generation polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) via downstream eIF5A hypusination. Genetic...
Gastrointestinal stromal tumor (GIST) is known for its wide variability in biological behaviors and it difficult to predict malignant potential. The aim of this study explore the characteristics prognostic factors GIST. Clinical pathological data 497 GIST patients our center between 1997 2012 were reviewed. Patients categorized into very low-, intermediate- high-risk groups according modified National Institutes Health (NIH) consensus classification system. Among 401 untreated with imatinib...
Abstract Background The pathophysiology of obsessive-compulsive disorder (OCD) remains unclear despite extensive neuroimaging work on the disorder. Exposure to medication and comorbid mental disorders can confound results OCD studies. goal this study was explore differences in brain functional connectivity (FC) within cortico-striato-thalamo-cortical (CSTC) loop drug-naïve drug-free patients healthy controls (HCs). Methods A total 29 patients, 22 25 HCs matched age, gender education level...
Abstract Genome-wide association studies (GWASs) implicate 16q22.1 locus in risk for colorectal cancer (CRC). However, the underlying oncogenic mechanisms remain unknown. Here, through comprehensive filtration, we prioritized rs7198799, a common SNP second intron of CDH1, as putative causal variant. In addition, found an CRC-risk allele C rs7198799 with elevated transcript level biological plausible candidate gene ZFP90 via expression quantitative trait loci analysis. Mechanistically,...
Abstract Background As a rare subtype of prostate carcinoma, basal cell carcinoma (BCC) has not been studied extensively and thus lacks systematic molecular characterization. Methods Here, we applied single‐cell genomic amplification RNA‐Seq to specimen human BCC (CK34βE12 + /P63 /PAP − /PSA ). The mutational landscape was obtained via whole exome sequencing the mixture 49 single cells, transcriptomes 69 cells were also obtained. Results five putative driver genes mutated in are CASC5 ,...
Surface modification with oxide nanostructures is one of the efficient ways to improve physical or biomedical properties shape memory alloys. This work reports a fabrication highly ordered Ti-Ni-O nanotube arrays on Ti-Ni alloy substrates through pulse anodization in glycerol-based electrolytes. The effects parameters and annealing process microstructures surface morphology were studied using scanning electron microscope Raman spectroscopy. electrolyte type greatly affected formation arrays....
Despite intensive efforts, a considerable proportion of colorectal cancer (CRC) patients develop local recurrence and distant metastasis. Stomatin-like protein 2 (SLP-2), member the highly conserved stomatin superfamily, is upregulated across types. However, biological functional roles SLP-2 remain elusive in CRC. Here, we report that high expression was found CRC tissues linked to tumor progression cell differentiation. Additionally, correlated with poor overall survival (OS) (p < 0.001)....
// Meng-Dan Xu 1, * , Shu-Ling Liu 2, Yi-Zhong Feng 3, Qiang 4, Meng Shen 1 Qiaoming Zhi 5 Zeyi 6 Dong-Mei Gu 7 Jie Yu Liu-Mei Shou 8 Fei-Ran Gong 9 Qi Zhu 10 Weiming Duan Kai Chen Junning Zhang 2 Meng-Yao Wu Min Tao 11, 12, 13 Wei Li 12 Department of Oncology, The First Affiliated Hospital Soochow University, Suzhou 215006, China Radiation 3 Pathology, Second 4 Renji to Shanghai Jiao Tong University School Medicine, 200000, General Surgery, Respiratory Zhejiang Chinese Medicine Hangzhou...
A minimal amount of information about a word must be phonologically and phonetically encoded before person can begin to utter that word. Most researchers assume the minimum is complete or possibly initial syllable. However, there some evidence segment sufficient based on longer durations when primed. In two experiments in which monosyllabic primed not primed, we present additional very short absolute response times determined basis acoustic articulatory onset relative presentation target. We...