A5100398047- Chinese history and philosophy
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Analysis
- Biochemical Analysis and Sensing Techniques
- Liver Disease Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Ion Channels and Receptors
- Adipose Tissue and Metabolism
- Advanced Chemical Sensor Technologies
- Receptor Mechanisms and Signaling
- Infant Nutrition and Health
- Meat and Animal Product Quality
- Neonatal Respiratory Health Research
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- Hepatitis C virus research
- Lipid metabolism and biosynthesis
- Selenium in Biological Systems
- Mitochondrial Function and Pathology
- Horticultural and Viticultural Research
- Biochemical effects in animals
- Diet, Metabolism, and Disease
- Allergic Rhinitis and Sensitization
Jilin University
2024-2025
First Hospital of Jilin University
2024-2025
Soochow University
2025
Sichuan Agricultural University
2025
Tianjin Medical University
2022-2025
Zhongshan Hospital of Xiamen University
2025
Fudan University
2025
Shandong University of Traditional Chinese Medicine
2024
Beijing University of Chinese Medicine
2013-2024
China Academy of Chinese Medical Sciences
2024
Abstract The resinous metabolites commonly known as frankincense or olibanum are produced by trees of the genus Boswellia and have attracted increasing popularity in Western countries last decade for their various pharmacological activities. This review described specific details mainly on anti-inflammatory, anti-carcinogenic, anti-bacterial apoptosis-regulating activities individual triterpenoid together with relevant mechanism. In addition, species-characterizing triterpenic markers...
Oxidative stress is the main pathogenesis of diabetic microangiopathy, which can cause microvascular endothelial cell damage and destroy vascular barrier. In this study, it found that carnosol protects human cells (HMVEC) through antioxidative mechanisms. First, we measured antioxidant activity carnosol. We showed pretreatment suppressed tert-butyl hydroperoxide (t-BHP)-induced viability, affected production lactate dehydrogenase (LDH) as well reactive oxygen species (ROS), increased produce...
Abstract Bitter taste receptors (TAS2Rs) have attracted a great deal of interest because their recently described bronchodilator and anti-inflammatory properties. The aim this study was to identify natural direct TAS2R14 agonists from Radix Bupleuri that can inhibit mast cell degranulation. A ligand-based virtual screening conducted on library chemicals contained in compositions , these analyses were followed by cell-based functional validation through HEK293-TAS2R14-G16gust44 line...
Saturated fatty acid (SFA) and unsaturated (UFA) have distinct impacts on health. Whether SFA UFA are differentially transported in liver remains elusive. Here, we find the secretion of but not esters is retarded a male mouse hepatic endoplasmic reticulum (ER) stress model. Among 13 members protein disulfide isomerase (PDI) family, only PDIA1 deficiency leads to hepatosteatosis hypolipidemia. In PDI-deficient liver, there severe accumulation secretory blockade esters, whereas remain normal....
Summary Rural social work is instrumental in addressing grassroots issues and fostering rural community development, an understanding of network structure can enhance service efficiency quality. The research explores the effectiveness by employing analysis within project “Seven Colors Light” Village M, County A, China. study analyzes interaction patterns among government agencies, professional workers, other stakeholders, emphasizing need for structures to delivery Findings findings...
Newborns exhibit a heightened vulnerability to inflammatory disorders due their underdeveloped immune system, yet the underlying mechanisms remain poorly understood. Here we report that plasma spermidine is correlated with maturity of human newborns and reduced risk inflammation. Administration led remission neonatal inflammation in mice. Mechanistic studies revealed enhanced generation polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) via downstream eIF5A hypusination. Genetic...
The enhancement of solubility or bioavailability can be achieved by stabilizing the metastable solid state reducing particle size, particularly for pharmaceutical candidates classified under biopharmaceutics classification system (BCS) II....
Traditional studies on transforming selenate and selenite are often limited by static measurements low spatial resolution. They do not fully consider the impact of moisture content. This paper uses DGT (diffusive gradients in thin films) technique to deeply explore how changes affect transformation environment (changes properties over time). First, representative soil samples (loess) prepared, their content is adjusted. Fixed concentrations added, then device simulates migration natural...
Diffuse large B-cell lymphoma (DLBCL) is a common and highly aggressive type of lymphoma. Iron metabolism plays critical role in human diseases, however, which remains unclear DLBCL patients. The study to explore the genetic characteristics molecular mechanisms underlying ferroptosis Based on GEO, GeneCards database, weighted gene co-expression network analysis was performed sample iron metabolism-related datasets. Enrichment (Gene Ontology/Kyoto Encyclopedia Genes Genomes set enrichment...
Rhodiola plants are used as a natural remedy in the western world and traditional herbal medicine China, valued for their ability to enhance human resistance stress or fatigue promote longevity. Due morphological similarities among different species, identification of genus remains somewhat controversial, which may affect safety effectiveness clinical use.In this paper, 47 samples seven species were collected from thirteen local provinces China. They identified by characteristics genetic...
The increasing demand for safe and effective treatments of chronic pain has promoted the investigation novel analgesic drugs. Some herbals have been known to be able relieve pain, while chemical basis target involved in this process remained clarified. current study aimed find anti-nociceptive candidates targeting transient receptor potential ankyrin 1 (TRPA1), a that implicates hyperalgesia neurogenic inflammation. In study, 156 chemicals were tested blocking HEK293/TRPA1 ion channel by...
Necrotizing enterocolitis (NEC) is a common disorder in premature infants that characterized by hyperinflammation and severe necrosis the intestine. The pathogenesis of NEC remains to be elucidated. In this study, we demonstrate adenosine, metabolite more abundant than adults, plays an important role prevention NEC. Administration adenosine or its analog, adenosine-5'-N-ethyluronamide (NECA), dramatically relieved severity neonatal mice. Meanwhile, treatment significantly enhanced...
Endothelin-1 (ET-1) autocrine and paracrine signaling modulate cell proliferation of tumor cells by activating its receptors, endothelin A receptor (ETAR) B (ETBR). Dysregulation ETAR activation promotes development progression. The potential antagonists the dual-ETAR ETBR as therapeutic approaches are under preclinical clinical studies. Salvianolic acid (Sal A) is a hydrophilic polyphenolic derivative isolated from Salvia miltiorrhiza Bunge (Danshen), which has been reported an anti-cancer...
Abstract Whether Selenium (Se) deficiency relates with adverse prognosis in Chinese patients heart failure (HF) is still unknown. This study aimed to investigate the association of serum Se level and outcomes HF a population. Patients examination were retrospectively included. Baseline information collected at patient’s first admission. The primary secondary all-cause mortality rehospitalization for during follow-up, respectively. participants divided into quartiles according their...