A5062628719- Natural product bioactivities and synthesis
- Mosquito-borne diseases and control
- Epigenetics and DNA Methylation
- Ginseng Biological Effects and Applications
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and Biological Activities
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Histone Deacetylase Inhibitors Research
- Advanced Welding Techniques Analysis
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Welding Techniques and Residual Stresses
- Insect symbiosis and bacterial influences
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Essential Oils and Antimicrobial Activity
- Insect and Pesticide Research
- Phytochemicals and Antioxidant Activities
- Natural Compounds in Disease Treatment
- Pharmacological Effects of Medicinal Plants
- Non-Destructive Testing Techniques
- Bioactive Compounds and Antitumor Agents
- Circular RNAs in diseases
Wuhan University
2023-2025
Zhongnan Hospital of Wuhan University
2024-2025
Sichuan University
2025
University of Edinburgh
2025
Southern Medical University
2021-2024
Tongji University
2024
Tongji Hospital
2024
University of Oulu
2022-2024
Dalian Jiaotong University
2023-2024
Lishui University
2021-2023
During the traumatic brain injury (TBI), improved expression of circulatory miR-21 serves as a diagnostic feature. Low levels exosome-miR-21 in can effectively improve neuroinflammation and blood-brain barrier (BBB) permeability, reduce nerve apoptosis, restore neural function ameliorate TBI. We evaluated role macrophage derived exosomes-miR-21 (M-Exos-miR-21) disrupting BBB, deteriorating TBI, Rg1 interventions. IL-1β-induced macrophages (IIM)-Exos-miR-21 activate NF-κB signaling pathway...
Acetaminophen (APAP) refers to a medication used manage pain and fever symptoms, but it always causes liver injury when overdosed. Zhishi, dried young fruit of Citrus aurantium L., is famous herbal medicine in Asian countries which rich dietary phenolic substances. In this study, the mechanism Zhishi protected against APAP-induced was studied more deeply by metabolomic strategy pharmacological study. The metabolomics results demonstrated that can prevent model regulating metabolic disorders...
Abstract The resinous metabolites commonly known as frankincense or olibanum are produced by trees of the genus Boswellia and have attracted increasing popularity in Western countries last decade for their various pharmacological activities. This review described specific details mainly on anti-inflammatory, anti-carcinogenic, anti-bacterial apoptosis-regulating activities individual triterpenoid together with relevant mechanism. In addition, species-characterizing triterpenic markers...
This manuscript elaborates on the establishment of a chemotaxonomic classification strategy for closely-related Citrus fruits in Traditional Chinese Medicines (TCMs). UPLC-Q-TOF-MS-based metabolomics was applied to depict variable markers and elucidate metabolic mechanism TCMs from different species at ripening stages. Metabolomics can capture comprehensive analysis small molecule metabolites provide powerful approach establish profiling, creating bridge between genotype phenotype. To...
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by destructive synovitis and associated with progressive disability, systemic difficulties, premature death, socioeconomic costs. Early intervention disease-modifying antirheumatic drugs (DMARDs) like methotrexate (MTX) its combination regimen would provide obvious benefits to patients, healthcare systems society. MTX tripterygium glycosides tablets (TGTS) are most frequently prescribed medicines for RA, the of them...
Upset, also known as “diaphragmatic spasm”, is a kind of qi against the upward impulse, throat er continuous sound, short and frequent sound difficult to self-control for characteristics disease. Chinese medicine will be categorized “retch” category, that its pathology mostly due gastric reversal, diaphragm, emotional disorders, dietary or cold heat internal factors related. Modern medical treatment often based on drug inhibition phrenic nerve excitation, but it easy accompanied by dry...
Chronic kidney disease (CKD) is a progressive with limited therapeutic options, necessitating novel approaches for management. N6-methyladenosine (m6A) modification has emerged as key regulator of gene expression in CKD, influencing pathways involved inflammation, fibrosis, and cellular stress. METTL3 plays crucial role modifying RNA, its overexpression linked to the activation pro-fibrotic inflammatory signaling pathways, such TGF-1 NF-B. Consequently, inhibition been explored potential...
Ginsenoside metabolite compound K (CK) is an active produced by ginsenosides in vivo that has anti-arthritic effect related to the glucocorticoid receptor (GR). However, potential mechanisms of CK remain unclear.This study explores role and vitro.Adjuvant arthritis (AA) model was induced Sprague-Dawley (SD) rats; rats were randomly divided into four groups (n = 10): normal, AA, (80 mg/kg), dexamethasone (Dex) group (1 mg/kg). From day 15, treated with (once a day, i.g.) Dex every 3 days,...
Citrus fruit is an important health-promoting food that rich in dietary phenolic metabolites. Traditional Chinese medicines, such as Zhishi and Zhiqiao, come from young immature fruits of cultivars. The preparation diversified bioactive products establishment the corresponding quality control methodology are challenging necessary. In current study, four types solid-phase extraction sorbents for enrichment clean-up matrix were evaluated. A column coated with Strata-X was finally used...
Abstract Background Zika virus (ZIKV) and dengue (DENV) are closely related flaviviruses primarily transmitted by Aedes mosquitoes. Armigeres subalbatus is an emerging widely distributed mosquito, ZIKV has been detected isolated from it. However, it not clear whether Ar. s ubalbatus could be a vector for DENV or not. In this study, we investigated the infection transmission of to DENV. Methods A line was Guangdong, China, further identified mitochondrial cytochrome oxidase subunit 1 ( COI )...
Mosquito densoviruses (MDVs) are mosquito-specific viruses that recommended as mosquito bio-control agents. The MDV Aedes aegypti densovirus (AeDNV) is a good candidate for controlling mosquitoes. However, the slow activity restricts their widespread use vector control. In this study, we introduced Bacillus thuringiensis (Bti) toxin Cry11Aa domain II loop α8 and Cyt1Aa β6-αE peptides into AeDNV genome to improve its mosquitocidal efficiency; protein expression was confirmed using nanoscale...
Accumulating evidence indicates that circular RNAs have major roles in the progression of human cancers. Nevertheless, molecular mechanism and effects circFAM126A oral squamous cell carcinoma (OSCC) remain unclear.Quantitative real-time PCR (qRT-PCR) was used to detect expression levels OSCC tumor tissues lines; small hairpin RNA (shRNA) on proliferation, migration, invasion cells were detected by MTT, colony formation, transwell assays; xenograft mouse models determine shRNA growth tumors...