A5101459979- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bone Metabolism and Diseases
- Bone health and treatments
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Ginkgo biloba and Cashew Applications
- Magnetic properties of thin films
- Natural Compounds in Disease Treatment
- FOXO transcription factor regulation
- Lipid metabolism and disorders
- Gastrointestinal Tumor Research and Treatment
- Bioactive Compounds and Antitumor Agents
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Sinusitis and nasal conditions
- DNA and Nucleic Acid Chemistry
- Metal complexes synthesis and properties
- Apelin-related biomedical research
Dalian Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Sichuan Academy of Agricultural Sciences
2025
First People's Hospital of Chongqing
2024-2025
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2024
Shanghai Changzheng Hospital
2019-2023
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Second Military Medical University
2014-2022
BackgroundPancreatic cancer (PC) is one of the most lethal solid malignancies in world due to its excessive cell proliferation and aggressive metastatic features. Emerging evidences revealed importance posttranscriptional modifications RNAs PC progression. However, knowledge about 5-methylcytosine (m5C) RNA modification still extremely limited. In this study, we attempted explore expression changes clinical significances 12 known m5C-related genes among patients.MethodsA total 362 normal 382...
Ya'an Tibetan tea, renowned as a mysterious has been used traditional remedy for disease prevention among ethnic minorities in the Qinghai-Tibet Plateau region, which experiences highest levels of UVB radiation world, over 1000 years. Theabrownin (TB) from tea exhibits various health benefits. In this study, preventive effects TB on UVB-induced skin damage were investigated. The results showed that pretreatment significantly alleviated visible damage, epidermal hyperplasia, and collagen...
Background Extracellular matrix metalloproteinase inducer (EMMPRIN) has been considered as a key promoting factor in atherosclerosis (AS). Some studies have shown that regulating EMMPRIN expression bone marrow-derived macrophages (BMDMs) of ApoE−/− mice can affect plaque stability, but the mechanism was not clear. Methods AS model were built from high-fat-feeding ApoE −/− mice, and divided into siE group CON group. The BMDMs aortas harvested following vivo treatment with either short...
<title>Abstract</title> <bold>Objective</bold> To investigate a rare adult case of choroid plexus carcinoma (CPC), with focus on identifying genetic variations and their implications for prognosis treatment selection. <bold>Methods</bold> The patient was diagnosed Magnetic Resonance Imaging (MRI) imaging histopathological features. Next-generation sequencing (NGS) conducted to identify aberrations. Expression FGFR2 FGF19/FGF3/FGF4/CCND1 (11q13 locus genes) identified in our were further...
Pancreatic cancer is regarded as the most fatal and aggressive malignancy due to its low 5‐year survival rate poor prognosis. The approaches of early diagnosis treatment are limited, which makes it urgent identify complex mechanism pancreatic oncogenesis. In this study, we used RNA‐seq investigate transcriptomic (mRNA miRNA) profiles in paired tumor normal samples from ten patients. More than 1000 differentially expressed genes were identified, nearly half also found be majority examined...
Pancreatic neuroendocrine neoplasms (pNENs) are endocrine tumors arising in pancreas and is the most common tumors. Mounting evidence indicates lncRNA H19 could be a determinant of tumor progression. However, expression mechanism relevant genes mediated by pNENs remain undefined. Microarray analysis was conducted to identify differentially expressed lncRNAs pNENs. analyzed 39 paired pNEN tissues qPCR. The biological role determined functional experiments. RNA pulldown, mass spectroscopy...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with a marked potential for invasion and metastasis. Emerging evidence has suggested that dysregulation long non-coding RNAs (lncRNAs) associated development multiple types cancer. However, function lncRNAs in PDAC poorly known. In present study, microarray assay was used to screen differently expressed it identified cancer upregulated drug resistance (CUDR) PDAC. CUDR increased cell proliferation, migration...
Pancreatic cancer is a highly lethal malignancy due to failures of early detection and high metastasis in patients. While certain genetic mutations tumors are associated with severity, the molecular mechanisms responsible for progression still poorly understood. Synaptotagmin-8 (SYT8) membrane protein that regulates hormone secretion neurotransmission, its expression positively regulated by promoter insulin gene pancreatic islet cells. In this study, we identified previously unknown role...
Abstract Background Emerging evidence has shown the crucial roles of pleomorphic adenoma gene ( PLAG ) family genes in multiple cancers. However, their functions and mechanisms pancreatic adenocarcinoma (PAAD) remain poorly understood. Methods We analyzed expression levels both The Cancer Genome Atlas (TCGA) database a Gene Expression Omnibus (GEO) database, confirmed results our three independent cohorts 382 PAAD tissues 362 adjacent nontumor tissues. Integrated analyses were carried out to...
Abstract This study explores the effects of apelin on retinal microglial cells in rat models oxygen‐induced retinopathy prematurity (ROP). Totally, 274 rats were selected for establishing (OIR) models, and 92 healthy control group. OIR assigned into OIR, 10 −5 g/L apelin, −4 −3 groups. Immunohistochemistry was employed to determine morphology cell number. CDllb, ionized calcium‐binding adapter molecule 1 (IBA‐1), TNF‐α, iNOS mRNA protein expressions identified using RT‐qPCR Western blotting,...
Background. Pancreatic cancer is a highly malignant solid tumor with high lethality rate, but there lack of clinical biomarkers that can assess patient prognosis to optimize treatment. Methods. Gene-expression datasets pancreatic tissues and normal were obtained from the GEO database, differentially expressed genes analysis WGCNA performed after merging normalizing datasets. Univariate Cox regression Lasso used screen prognosis-related in modules strongest association construct risk...
This study aimed to develop a liver metastasis-related gene prognostic index (LMPI) for pancreatic ductal adenocarcinoma prognosis and therapy.The Cancer Genome Atlas data set was used identify hub genes via weighted coexpression network analysis. The core were identified construct an LMPI by using the Cox regression method. An immune cell abundance identifier applied determine abundance.A total of 78 in black module significantly enriched complement coagulation cascades, fat digestion...
To investigate the feasibility of transfecting TNF-related apoptosis-inducing ligand (TRAIL) gene into neural stem cells (NSCs) in vitro, and explore whether NSCs retain their proliferative differentiated activities after transfection.
Pancreatic cancer (PCa) is one of the most aggressive lethal malignancies, and metastasis major cause PCa-associated death. F-box/LRR-repeat protein 7 (FBXL7) regulates chemosensitivity human pancreatic cancer. However, clinical significance biological role FBXL7 in PCa have been rarely studied. In this study, we found that expression was down-regulated tissues compared with tumor-adjacent tissues, low positively associated metastasis. Functionally, overexpression attenuated PANC1 cell...
Pancreatic cancer (PC) is one of the most invasive and metastatic neoplasms among fatal malignancies digestive system. Abnormal expression genes long non-coding RNAs (lncRNAs) are reportedly linked to multiple cancers. However, lncRNA-mRNA profiles their molecular mechanisms in PC progression poorly known. This study aimed map hub lncRNAs which might play core roles development PC.This used microarray analysis screen for both differentially expressed (DEGs) (DElncRNAs) between matched...
Pancreatic fistula is a life-threatening complication of pancreaticoduodenectomy. Omega-like duct-to-mucosa pancreatojejunostomy novel technique which helps reduce the risk fistulation. This study aimed to compare early postoperative outcomes omega-like and conventional pancreatojejunostomy.A retrospective single-centre cohort comparing adult patients who underwent open pancreatoduodenectomy with (CDMP) or (ODMP) between 1 January 2015 31 December 2019. The primary outcome measure was...