A5100336373- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- PARP inhibition in cancer therapy
- Cell death mechanisms and regulation
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Brain Metastases and Treatment
- Cancer-related molecular mechanisms research
- Head and Neck Surgical Oncology
- CAR-T cell therapy research
- Cancer, Lipids, and Metabolism
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Colorectal and Anal Carcinomas
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Landslides and related hazards
- Colorectal Cancer Treatments and Studies
- Inflammatory Biomarkers in Disease Prognosis
- Protease and Inhibitor Mechanisms
Kunming Medical University
2013-2025
Guangxi Medical University
2001-2025
Northeast Agricultural University
2025
North Sichuan Medical University
2022-2025
Peking University
2025
Guangxi University of Chinese Medicine
2024-2025
Shandong Academy of Sciences
2025
Shandong University
2025
Tsinghua University
2024
Children's Hospital of Chongqing Medical University
2022-2024
Abstract Background Glucose-6-phosphate dehydrogenase (G6PD), elevated in tumor cells, catalyzes the first reaction pentose-phosphate pathway. The regulation mechanism of G6PD and pathological change human melanoma growth remains unknown. Methods HEM (human epidermal melanocyte) cells with wild-type gene (A375-WT), deficiency (A375-G6PD∆), cDNA overexpression (A375-G6PD∆-G6PD-WT), mutant (A375-G6PD∆-G6PD-G487A) were subcutaneously injected into 5 groups nude mice. Expressions G6PD, STAT3,...
Abstract Olaparib is an FDA-approved PARP inhibitor (PARPi) that has shown promise as a synthetic lethal treatment approach for BRCA-mutant castration-resistant prostate cancer (CRPC) in clinical use. However, emerging data have also even cells may be resistant to PARPi. The mechanistic basis these drug resistances poorly understood. Polo-like kinase 1 (Plk1), critical regulator of many cell-cycle events, significantly elevated upon castration mice carrying xenograft tumors. Herein, by...
[18F]fluoro‑2‑deoxyglucose (FDG) positron emission tomography (PET)‑computed (CT) is a functional imaging modality based on glucose metabolism. The association between the maximum standardized uptake value (SUVmax) from 18F‑FDG PET‑CT scanning and epidermal growth factor receptor (EGFR) mutation status has, to best of our knowledge, not previously been fully elucidated, potential mechanisms by which EGFR mutations alter FDG are largely unknown. A total 157 patients who were pathologically...
Tripterygium glycosides (TGs) are the most common form of traditional Chinese medicine, known as wilfordii Hook F (TWHF) [...].
Adenomyoepithelioma (AME) is a relatively rare type of tumor formed by the coordinated proliferation glandular epithelial cells and myoepithelial cells. Clinically, most them are benign, while malignant ones extremely rare. Malignant breast adenomyoepithelioma somewhat invasive may recur locally or metastasize distantly through vascular pathway. However, reports on axillary lymph node metastasis scarce. In this case, we present an instance with metastasis. By combining previous studies,...
Fluence-to-dose conversion coefficients are fundamental ingredients to calculate astronaut radiation dose in space. For this purpose, the for isotropic provided by International Commission on Radiological Protection Publication 123 (ICRP123) widely used. Understanding uncertainties these is important a precise calculation of dose. In work, we present systematic study unshielded calculated means GEANT4 Monte Carlo simulation toolkit and human voxel phantoms defined ICRP 110. Four physics...
To understand the effects of endophytic fungus Y118 on physiological characteristics Zanthoxylum nitidum (Roxb.) DC after co-culture with its host nitidum, we measured plant growth index (dry root weight) at different stages using solid fermentation medium containing Y118. Physiological and biochemical indexes (defensive enzyme activity) were determined by chromatographic analysis contents chloride chelidonine, main active ingredients in root. At 3, 9 12 months, dry weight treatment group...
The retraction note addresses allegations concerning the published article titled “Efficacy and safety analysis of transarterial chemoembolization radioembolization in advanced hepatocellular carcinoma descending hepatectomy”. World J Gastrointest Surg 2023; 15: 687-697 . To preserve academic integrity avoid misleading readers, authors agreed to retract article, due significant concerns regarding reliability data obtained by exploratory, non-standardized interventional procedures ethical...
Pancreatic cancer is one of the most malignant gastrointestinal tumors, and it great significance to explore molecular mechanism its progression find new biological therapeutic targets. CIRBP a cold-induced protein that plays key role in many physiological pathological processes, but pancreatic still unclear. The expression tissues was slightly lower than normal tissues, high beneficial survival. At same time, immunohistochemical detection showed level cytoplasm significantly adjacent...
Accurate segmentation of lung nodules is crucial for the early diagnosis and treatment cancer in clinical practice. However, similarity between surrounding tissues has made their a longstanding challenge.
Since altered energy metabolism is a hallmark of cancer, many drugs targeting metabolic pathways are in active clinical trials. The tumor suppressor p53 often inactivated either through downregulation protein or loss-of-function mutations. As such, stabilization considered as one promising approach to treat those cancers carrying wild type (WT) p53. Herein, SIRT1 inhibitor Tenovin-1 and polo-like kinase 1 (Plk1) BI2536 were used stabilize We found that both Tennovin-1 increased the...
The purpose of this study was to compare the quality life (QoL) stage II nasopharyngeal carcinoma (NPC) patients treated with radiotherapy (RT) versus concurrent chemoradiotherapy (CCRT). In a cross-sectional study, these were RT (n = 55) or CCRT 51) between June 2008 and 2013. For all subjects, disease-free survival more than 3 years. QoL assessed using European Organization for Research Treatment Cancer Quality Life Questionnaire-Core 30 (EORTC QLQ-C30) questions Head Neck 35 QLQ-H&N35)...
The aim of this study was to evaluate the efficiency and safety methimazole (MMI) propylthiouracil (PTU) in treatment hyperthyroidism.Articles were searched through PubMed, EMBASE, Cochrane Library, Web Science, CNKI, Wanfang, QVIP. primary outcomes clinical efficacy thyroid hormone levels MMI PTU groups. secondary liver function indexes adverse reactions Results expressed as weighted mean difference (WMD) or odds ratio (OR) with 95% confidence intervals (CIs). Begg test applied assess...