A5009407159- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Helicobacter pylori-related gastroenterology studies
- Chromatin Remodeling and Cancer
- COVID-19 Clinical Research Studies
- Glycosylation and Glycoproteins Research
- Digestive system and related health
- Ovarian cancer diagnosis and treatment
- COVID-19 and healthcare impacts
- Metastasis and carcinoma case studies
- Head and Neck Anomalies
- Colorectal Cancer Screening and Detection
- Neuroblastoma Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Aortic aneurysm repair treatments
- Circular RNAs in diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pregnancy and preeclampsia studies
- Peptidase Inhibition and Analysis
- Macrophage Migration Inhibitory Factor
- Neurological Disorders and Treatments
- Uterine Myomas and Treatments
Command Hospital
2025
General Hospital of Central Theater Command
2025
Case Western Reserve University
2015-2024
University of Wisconsin–Madison
2023
University Hospitals of Cleveland
2017-2022
University Hospitals Cleveland Medical Center
2015-2021
Department of Embryology
2014-2016
Fred Hutch Cancer Center
2014
Cornell University
2014
Small cell lung carcinoma (SCLC) is a highly metastatic tumor type with neuroendocrine features and dismal prognosis. PTEN mutations PIK3CA activating have been reported in SCLC but the functional relevance of this pathway unknown. The PTEN/PIK3CA was interrogated using an AdenoCre-driven mouse model harboring inactivated Rb p53. Inactivation one allele Rb/p53-deleted mice led to accelerated frequent metastasis liver. In contrast high mutation burden human SCLC, exome analyses revealed low...
BACKGROUND The sensitivity and specificity of positron emission tomography (PET) have been significantly improved for the identification malignancies in recent years; however, it is still necessary to confirm PET findings a lymph node (LN) by direct tissue sampling. Endobronchial ultrasound–guided transbronchial needle aspiration (EBUS‐TBNA) most commonly used approach diagnosing staging mediastinal LNs, particularly lung cancer patients with locally advanced disease. Despite this fact,...
<title>Abstract</title> <bold>Background and aims</bold>: The reasons for the significantly higher prevalence of intracranial atherosclerotic stenosis (ICAS) compared to extracranial (ECAS) in Asian population remain unclear. This paper investigated whether diabetes mellitus is correlated with this difference. <bold>Methods</bold>: A retrospective analysis was conducted on clinical records patients who consulted Neurology Department. Magnetic resonance angiography color Doppler ultrasound...
Sessile serrated adenoma/polyp (SSA/p) is a precancerous lesion, and its differential diagnosis from hyperplastic polyp (HP) could be challenging in certain circumstances based on morphology alone. Hes1 downstream target of Notch-signaling pathway plays an important role intestinal development by regulating differentiation enterocytes. In this study, we evaluated the expression patterns SSA/p HP, determine whether immunostaining can help differentiate between these 2 entities. Serrated...
To explore the mechanism underlying micro ribonucleic acid (miR)-21 in invasion of rat aortic aneurysm cells vitro by regulating matrix metalloproteinase (MMP)-2 and MMP-9.Rats were randomly divided into three groups: control group, model miR-21 group. Real Time fluorescence quantitative Polymerase Chain Reaction (qRT-PCR) was adopted to detect levels each group cells, transwell assay performed measure effect on cells. Western blotting used examine expression PTEN, which is predicted target...
ABSTRACT Infection of the gastrointestinal tract by Histoplasma capsulatum is generally considered to be a manifestation disseminated disease. The most common symptoms from histoplasmosis include abdominal pain and diarrhea. Isolated asymptomatic unusual, diagnosis can challenging. We report 57-year-old man with history liver transplant presented numerous colonic polyps, biopsies demonstrated granulomatous colitis fungal microorganism consistent H. . Antigen/antibody tests for were...
Background With the increased use of whole body fluorodeoxyglucose positron emission tomography (PET) scan for staging/restaging or primary diagnosis neoplasia, thyroid incidentalomas have become more common. The limited reports PET‐positive showed incidence malignancy ranging from 14 to 66%, and there is discrepancy in terms diagnostic significance standard uptake value (SUV) value. Methods This a retrospective study 20 PET which had cytological evaluation October 2009 February 2015 at...
Upper gastrointestinal metastasis of endometrial carcinoma rarely occurs in the absence locoregional disease and other distant metastases. We describe herein unique case an isolated gastric a stage I adenocarcinoma. Because metastatic tumor was initially misdiagnosed clinically pathologically as primary carcinoma, we illustrate histopathology review pertinent literature. A 42-year-old woman with Lynch syndrome underwent treatment adenocarcinoma at outside hospital comprising clinical...
Introduction. Neuroendocrine neoplasms (NENs) are that most commonly arise from gastrointestinal tract, pancreas, and lung. HES1 is a downstream target of Notch signaling pathway. The current literature about expression in NENs sparse inconsistent. Methods. In this study, we evaluated by immunohistochemistry total 32 cases NENs, including 13 well-differentiated neuroendocrine tumors 10 9 lung, 4 typical carcinoid, 1 case atypical carcinoma. intensity the stain was scored − to +++,...
Undifferentiated carcinoma of the esophagus is an entity that included in WHO classification digestive systems fifth edition (2018). The definition this a malignant esophageal epithelial tumor lacks definite microscopic features squamous, glandular, or neuroendocrine differentiation. It challenging diagnosis to make due lack diagnostic criteria. We report case from 45 years old man with mass lower third esophagus. Biopsy showed epitheloid neoplasm sheet like growth pattern and no glandular...
Malignant polyps are polypoid lesions that appear benign endoscopically but harbor invasive adenocarcinoma microscopically. Patient with diagnosis of malignant polyp can be managed by surgical resection or endoscopic surveillance. Current literature on long term recurrence is sparse. A total 76 patients and follow-up period over one year included. Of these, 28 underwent polypectomy followed surveillance (group 1). Forty-eight segmental colectomy 2). In group 1, three developed local...
Journal Article Markedly Elevated Liver Enzymes in a Young COVID-19 Positive Patient Get access Zhicheng Jin, Jin Department of Pathology and Laboratory Medicine, University Wisconsin—Madison, Madison, WI, United States https://orcid.org/0000-0003-2770-9549 Search for other works by this author on: Oxford Academic Google Scholar Yongjun Liu, Liu Medicine Pathology, Washington Medical Center, Seattle, WA, Min Cui Address correspondence to at: School Public Health, 600 Highland Ave., WI 53792,...
Deep vein thrombosis (DVT) commonly occurs among vascular diseases globally, for which circular RNAs (circRNAs) are becoming a promising option by mediating functions of human umbilical endothelial cells (HUVECs). Therefore, this study focuses on whether circ_0020123 plays role in HUVECs.Pregnant women with DVT (n = 39) and without were selected as the observation group control group, respectively. Circ_0020123 expression serum pregnant was assessed RT-qPCR. The risk factors analyzed single...
Low molecular weight heparin (LMWH) is the first-line therapy in acute cancer-associated venous thromboembolism (CAT). However, heparin-induced thrombocytopenia (HIT) a life-threatening adverse drug reaction that occurs anticoagulation with LMWH. This article reports case of 66-year-old Chinese male who received nadroparin 4100IU twice daily for treating CAT. Unfortunately, epistaxis persisted and blood count examination revealed serious on postoperative day 5. The patient was diagnosed HIT...
Introduction: Amyloidosis a systemic disorder characterized with extracellular deposition of fibrils in various tissues and organs. Reports amyloidal deposits confined to the stomach are rare. In this report we present case woman local AL (lambda)-type amyloid deposition. Case Description/Methods: 77-year old atrial fibrillation on warfarin presented emergency room fatigue. Hemoglobin was 9.3 g/dL INR 3.7. After admission, she had an episode melena hematemesis, followed by pre-syncope. IVF,...