A5031947337- Cancer Cells and Metastasis
- Liver physiology and pathology
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Lymphatic System and Diseases
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Microbial Community Ecology and Physiology
- Cancer, Hypoxia, and Metabolism
- Gout, Hyperuricemia, Uric Acid
- CAR-T cell therapy research
- Antibiotic Resistance in Bacteria
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Pharmaceutical and Antibiotic Environmental Impacts
- Gut microbiota and health
- Chemokine receptors and signaling
- Metabolism, Diabetes, and Cancer
- Helicobacter pylori-related gastroenterology studies
- Angiogenesis and VEGF in Cancer
- Liver Disease Diagnosis and Treatment
- Advanced Photocatalysis Techniques
Fudan University Shanghai Cancer Center
2022-2025
Shanghai Medical College of Fudan University
2022-2025
Taizhou Central Hospital
2024
Chinese Research Academy of Environmental Sciences
2023-2024
Zhejiang Cancer Hospital
2024
Chinese Academy of Sciences
2024
Taizhou University
2024
Yunnan Agricultural University
2023
Huazhong University of Science and Technology
2018-2022
Tongji Hospital
2018-2022
Abstract Background Liver cancer stem cells (LCSCs) contribute to hepatocellular carcinoma (HCC) development, metastasis, and drug resistance. MSI2 Notch1 signaling are involved in the maintenance of CSCs. However, it is unknown whether CD44v6+ LCSCs. Therefore, we investigated clinical significance function its relationship with stemness properties Methods The expression CD44v6 were detected by fresh specimens a HCC tissue microarray. microarray containing 82 samples was used analyze...
Abstract Cancer‐associated fibroblasts (CAFs) are heterogeneous stromal cells present in the tumor microenvironment (TME), which play a critical role gastric cancer (GC) progression. Here, we examined subset of CAFs with high podoplanin (PDPN) expression, is correlated metastasis and poor survival GC patients. Animal models liver monitored by micro‐PET/CT confirmed that periostin (POSTN) derived from PDPN(+) regulated CAFs’ pro‐migratory ability. Mechanistically, secreted POSTN to modulate...
The ability of carbohydrate antigen 19-9 (CA19-9) to differentiate pancreatic cancer from other benign lesions is unsatisfactory. This study explored the diagnostic value KRAS gene mutations and plasma circulating tumor DNA (ctDNA) in patients with cancer.The prospective cohort comprised 149 consecutive solid who underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). subtype were analyzed by digital droplet PCR (ddPCR) EUS-FNA histopathology tissue samples, blood samples...
Abstract Cancer‐associated fibroblasts (CAFs) are intrinsic components of the tumor microenvironment that promote cancer progression and metastasis. Through an unbiased integrated analysis gastric grade stage, we identified a subset proangiogenic CAFs characterized by high podoplanin (PDPN) expression, which significantly enriched in metastatic lesions secrete chemokine (CC‐motif) ligand 2 (CCL2). Mechanistically, PDPN(+) enhance angiogenesis activating AKT/NF‐κB signaling pathway. The...
Both cancer-associated fibroblasts (CAFs) and liver cancer stem cells (LCSCs) play an important part in the tumorigenesis, development metastasis of hepatocellular carcinoma (HCC). Moreover, stem-like properties HCC could be promoted by CAFs. However, mechanism remains largely unknown.We used conditioned medium (CM) CAFs to culture Huh7 cells. Stemness was then examined mainly sphere formation assay while stemness-associated genes including Nanog, Sox2 Oct4 were measured Western blotting....
Purpose: Because many hepatocellular carcinoma (HCC) cases develop from fibrotic or cirrhotic livers, fibroblasts are abundant in the microenvironment of HCC. Although contribution cancer-associated (CAFs) to progression HCC is well established, role has not been comprehensively revealed. Patients and methods: The RayBio Human Cytokine Antibody Array was used elucidate peri-tumor (PTFs) promoting malignant properties IL-6 STAT3 signaling were inhibited both cell lines non-tumor L-02 liver...
Prognosis of gastric cancer (GC) patients with ovarian metastasis (OM) remains poor. We hereby characterized the role tumor immune microenvironment (TIME) and identified potential key regulators in OM aim understanding its molecular basis to develop novel therapeutic targets.
Abstract Background Ovarian metastasis (OM) results in poor survival of gastric cancer (GC) patients. While immunotherapy has emerged as a promising approach for late‐stage GC, validated immune‐related prognostic signatures still remain need. In this study, we constructed an ovarian metastasis‐ and signature (OMIRPS), characterized the molecular immune features OMIRPS‐categorized subgroups predicted their potential response to immunotherapy. Methods Three individual cohorts were used...
Our study focused on freshwater fungal diversity, an important aspect in assessing the ecology of aquatic ecosystems. We carefully explored diversity and influencing factors culturable fungi across Dianchi Lake, Fuxian Xingyun Yangzonghai Lake Yunnan Province, China. Through culture, morphological characterization, ITS sequence analysis, we identified a total 565 isolates belonging to 405 species 133 genera. The indices viz. H′, D, J were evaluated for lakes. Interestingly, although highest...
Freshwater fungal diversity plays a pivotal role in assessing the ecology of aquatic ecosystems. This study aimed to explore and influencing factors culturable fungi across Dianchi Lake, Fuxian Xingyun Yangzonghai Lake Yunnan Province, China. Through culture, morphological characterization, ITS sequence analysis identified from these lakes. A total 565 strains belonging 405 species 133 genera were revealed. The indices H', D, J evaluated Although highest during summer at no significant...
Background: Liver cancer stem cells (LCSCs) contribute to hepatocellular carcinoma (HCC) development, metastasis, and drug resistance. MSI2 Notch1 signaling are involved in the promotion maintenance of CSCs. However, it is ambiguous if they CD44v6+ LCSCs. Therefore, we investigate clinical significance mechanism stemness properties LCSCs.Methods: The expression correlation CD44v6 were analyzed by a tissue microarray containing 88 HCC samples. CD44v6+/- isolated using microbeads sorting. We...
Abstract Background: Early diagnosis is critical in reducing pancreatic cancer mortality. We explore the diagnostic values of detecting KRAS gene mutations and plasma circulating tumor DNA (ctDNA) patients with primary cancer. Methods: The cohort study comprised 149 consecutive solid mass underwent Endoscopic ultrasound fine needle aspiration (EUS-FNA) between September, 2014 May, 2016. point (G12V, G12D, G12R) were analyzed by droplet digital PCR (ddPCR) EUS-guided (FNA) histopathology...