A5086942701- Cancer Cells and Metastasis
- interferon and immune responses
- RNA modifications and cancer
- Extracellular vesicles in disease
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- AI in cancer detection
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- ZnO doping and properties
- Colorectal Cancer Screening and Detection
- Advanced Photocatalysis Techniques
- Gastric Cancer Management and Outcomes
- Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Advanced Malware Detection Techniques
- Gestational Diabetes Research and Management
- Electrochemical Analysis and Applications
- Pregnancy and preeclampsia studies
Guangzhou Medical University
2005-2025
Guangzhou Sport University
2025
Guangzhou Medical University Cancer Hospital
2025
Xingtai University
2022-2024
Xinjiang University
2024
Xinjiang University of Science and Technology
2024
Guangdong Province Women and Children Hospital
2008-2024
China Three Gorges University
2022-2023
Guilin University of Technology
2022-2023
Zhejiang University
2022-2023
Epstein-Barr virus-associated gastric cancer (EBVaGC) shows a robust response to immune checkpoint inhibitors. Therefore, cost-efficient and accessible tool is needed for discriminating EBV status in patients with cancer. Here we introduce deep convolutional neural network called EBVNet its fusion pathologists predicting EBVaGC from histopathology. The yields an averaged area under the receiver operating curve (AUROC) of 0.969 internal cross validation, AUROC 0.941 on external dataset...
Pyroptosis is an inflammatory form of programmed cell death implicated in inflammation and disease. Moreover, inducing pyroptosis has been appreciated as anti-cancer therapy for its ability to unleash immune responses.Utilizing the data available The Cancer Genome Atlas (TCGA), pyroptosis-related genes' (PRGs) expression, genomic aberrations, clinical significance were systematically analyzed pan-cancer. A GSVA score was obtained rate level divide cancers into pyroptosis-low pyroptosis-high...
Oral biofilms, formed by multiple microorganisms and their extracellular polymeric substances, seriously affect people's life. The emergence of the resistance biofilms to conventional antibiotics side effects on oral cavity have posed a great challenge in treatment dental diseases. Recently, antimicrobial peptides been recognized as promising alternatives due broad antibacterial spectrum, high activity, specific mechanism. However, research anti-biofilm behaviors is still its infancy,...
Cancer stem-like cells have been well accepted to be involved in recurrence and metastasis of cancers, but the prognostic potential biomarkers integrating with cancer for colorectal is unclear.We identified three proteins, CLIC4, ERp29, Smac/DIABLO, from metastatic verified proteins' role behaviors. The proteins were detected by IHC tumors matched colonic mucosa patients who underwent radical surgery training cohort. associations between expression levels five-year disease-specific survival...
Accurate tumor diagnosis by pathologists relies on identifying specific morphological characteristics. However, summarizing these unique features in classifications can be challenging. Although deep learning models have been extensively studied for classification, their indirect and subjective interpretation obstructs from comprehending the model discerning accountable classifications. In this study, we introduce a new approach utilizing Style Generative Adversarial Networks, which enables...
<p>S2. There is no significant difference in endothelial apoptosis-associated proteins between nontumor tissues and NPC metastatic tissues.</p>
<p>S3. Identification of exosomes.</p>
<p>S8. Exosomes derived from NPC cells increase pyroptosis and vascular permeability in pulmonary hepatic endothelial of mice.</p>
<p>S5. Exosomes derived from NPC cells induce endothelial cell death.</p>
<p>S4. NPC serum exosomes induce endothelial cell proptosis.</p>
<div>Abstract<p>Extravasation is a key step in tumor metastasis. Epstein‒Barr virus plays crucial role nasopharyngeal carcinoma (NPC) However, the functions and molecular mechanisms of during cell extravasation remain unclear. Here, we showed that expression pyroptosis-associated proteins greater endothelial cells metastatic NPC tissues than those nontumor exosomes derived from promoted pyroptosis, vascular permeability, extravasation. Moreover, found BART2-5p abundant serum...
<p>S7. Exosomes derived from NPC cells increase vascular permeability.</p>
<p>S1. There is no significant difference in endothelial pyroptosis-associated proteins between nontumor nasopharyngeal tissues and primary NPC tissues.</p>
<p>S6. Detection of EBV in EBV-cleared or EBV-infected NPC cells.</p>
<p>Information for Supplementary Figure</p>
Combining molecular classification with clinicopathologic methods improves risk assessment and chooses therapies for endometrial cancer (EC). Detecting mismatch repair (MMR) deficiencies in EC is crucial screening Lynch syndrome identifying immunotherapy candidates. An affordable accessible tool urgently needed to determine MMR status patients. We introduce MMRNet, a deep convolutional neural network designed predict MMR-deficient from whole-slide images stained hematoxylin eosin. MMRNet...
Tumour-stroma ratio (TSR) is the proportion of tumour cells relative to surrounding stroma. This study aimed investigate prognostic impact TSR, and construct a nomogram in patients with nasopharyngeal carcinoma (NPC). Clinico-pathological data 206 treated at Guangzhou Institute Cancer Research, Affiliated Hospital, Medical University for NPC were used as training cohort. Assessment TSR was performed on haematoxylin eosin-stained slides correlation survival outcomes examined. A model...
The gut microbiota (GM) may play a crucial role in the development and progression of central nervous system (CNS) diseases. Microecologics exercise can influence composition function GM, thereby exerting positive effects on CNS. Combined interventions microecologics are expected to more comprehensively effectively address CNS diseases through microbiota–gut–brain axis (MGBA), potentially outperforming single interventions. However, there is currently lack relevant reviews this topic. In...