A5035438817- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ophthalmology and Eye Disorders
- Visual perception and processing mechanisms
- Glaucoma and retinal disorders
- Neural dynamics and brain function
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neural and Behavioral Psychology Studies
- Advanced Neural Network Applications
- Cerebral Venous Sinus Thrombosis
- Connexins and lens biology
- Lymphoma Diagnosis and Treatment
- Ear Surgery and Otitis Media
- Chronic Lymphocytic Leukemia Research
- Retinal Development and Disorders
- Amoebic Infections and Treatments
- Congenital Anomalies and Fetal Surgery
- Video Surveillance and Tracking Methods
- Receptor Mechanisms and Signaling
- CAR-T cell therapy research
- RNA regulation and disease
- Traumatic Brain Injury Research
- Intensive Care Unit Cognitive Disorders
University of Mississippi Medical Center
2016-2025
Wuhan University of Science and Technology
2024
Jackson Memorial Hospital
2012-2024
Zhuhai People's Hospital
2024
Loudi Central Hospital
2024
Sichuan University
2021-2023
Zhejiang University of Technology
2023
West China Hospital of Sichuan University
2021-2023
Beijing Electronic Science and Technology Institute
2022-2023
BeiGene (China)
2021-2022
Fifty percent of inner ear disorders are caused by genetic mutations. To develop treatments for disorders, we designed gene replacement therapies using synthetic adeno-associated viral vectors to deliver the coding sequence Transmembrane Channel-Like (Tmc) 1 or 2 into sensory hair cells mice with hearing and balance deficits due mutations in Tmc1 closely related Tmc2. Here report restoration function outer cells, enhanced cell survival, cochlear vestibular function, neural responses auditory...
Abstract Background Accurate and robust pathological image analysis for colorectal cancer (CRC) diagnosis is time-consuming knowledge-intensive, but essential CRC patients’ treatment. The current heavy workload of pathologists in clinics/hospitals may easily lead to unconscious misdiagnosis based on daily analyses. Methods Based a state-of-the-art transfer-learned deep convolutional neural network artificial intelligence (AI), we proposed novel patch aggregation strategy clinic using weakly...
Tmc1 and Tmc2 are essential pore-forming subunits of mechanosensory transduction channels localized to the tips stereovilli in auditory vestibular hair cells inner ear. To investigate expression function organs, we used quantitative polymerase chain reaction (qPCR), fluorescence situ hybridization – hairpin (FISH-HCR), immunostaining, FM1-43 uptake measured evoked potentials (VsEPs) ocular reflexes (VORs). We found that showed dynamic developmental changes, differences regional patterns,...
Sound activates not only the cochlea but also vestibular end organs. Research on this phenomenon led to discovery of sound-evoked myogenic potentials recorded from sternocleidomastoid muscles (cervical VEMP, or cVEMP). Since cVEMP offers simplicity and ability stimulate each labyrinth separately, its values as a test human function are widely recognized. Currently, is interpreted saccule based assumption that clicks primarily activate saccule. However, sound activation organs other than has...
Reward probability and uncertainty are two fundamental parameters of decision making. Whereas reward indicates the prospect winning, uncertainty, measured as variance probability, degree risk. Several lines evidence have suggested that anterior cingulate cortex (ACC) plays an important role in processing. What is lacking a quantitative analysis encoding human ACC. In this study, we addressed issue by analyzing feedback-related negativity (FRN), event-related potential (ERP) component...
Usher syndrome is a syndromic form of hereditary hearing impairment that includes sensorineural loss and delayed-onset retinitis pigmentosa (RP). Type 1 (USH1) characterized by congenital profound vestibular areflexia, with adolescent-onset RP. Systemic treatment antisense oligonucleotides (ASOs) targeting the human USH1C c.216G>A splicing mutation in knockin mouse model USH1 restores balance. Herein, we explore effect delivering ASOs locally to ear treat dysfunction associated syndrome....
The sensory cells that transduce the signals for hearing and balance are highly specialized mechanoreceptors called hair reside in epithelia of inner ear. Loss from toxin exposure age can cause disorders is essentially irreversible due to inability mammalian vestibular organs regenerate physiologically active cells. Here, we show substantial regeneration a mouse model damage by treatment with combination glycogen synthase kinase 3β histone deacetylase inhibitors. drugs stimulated supporting...
Many animals with laterally placed eyes, such as chameleons, move their eyes independently of one another. In contrast, primates frontally and binocular vision must them together so that both are aimed at the same point in visual space. Is coordination an innate feature how our brains wired, or have we simply learned to together? This question sparked a controversy 19(th) century between two eminent German scientists, Ewald Hering Hermann von Helmholtz. took position was vigorously...
Individuals suffering from Tullio phenomena experience dizziness, vertigo, and reflexive eye movements (nystagmus) when exposed to seemingly benign acoustic stimuli. The most common cause is a defect in the bone enclosing vestibular semicircular canals of inner ear. Surgical repair often corrects problem, but precise mechanisms underlying phenomenon are not known. In present work we quantified an animal model condition by recording fluid motion neural activity evoked auditory-frequency...
Introduction Calyx bearing vestibular afferent neurons innervating type I hair cells in the striolar region of utricle are exquisitely sensitive to auditory-frequency air conducted sound (ACS) and bone vibration (BCV). Here, we present experimental data a mathematical model utricular mechanics compound action potential generation (vCAP) response clinically relevant levels ACS BCV. Vibration otoconial layer relative sensory epithelium was simulated using Newtonian two-degree-of-freedom...
Abstract Usher syndrome type 1C (USH1C) is a genetic disorder caused by mutations in the USH1C gene, which encodes harmonin, key component of mechanoelectrical transduction complex auditory and vestibular hair cells. leads to deafness dysfunction humans. An Ush1c knockout (KO) mouse model displaying these characteristic deficits generated our laboratory. To examine gene replacement therapy (GT) this model, synthetic adeno‐associated viral vector, Anc80L65 , driving harmonin expression...
A bstract : New evidence has challenged a widely accepted interpretation of Hering's law equal innervation, which states that disjunctive saccades are produced by the linear addition conjugate and vergence innervation commands independent oculomotor subsystems. We hypothesize, instead, monocular premotor control network. model, based on this hypothesis consistent with known brain‐stem anatomy, simulates realistic including initial late slow movements.
Past studies have shown that reward contingency is critical for sensorimotor learning, and expectation speeds up saccades in animals. Whether monetary human remains unknown. Here we addressed this issue by employing a conditional saccade task, which subjects performed series of non-reflexive, visually-guided horizontal saccades. The were (or not) financially compensated making response to centrally-displayed visual congruent incongruent) stimulus. Reward modulation saccadic velocities was...
The serum triglyceride (TG) and total cholesterol (TC) levels have been reported altered in the traditional drug-dependence (such as marijuana heroin). However, studies assessing relationships among TC, TG, methamphetamine (MA)-dependence not described well. In this study, our aim is to explore TG TC large sample of MA-dependent patients. A retrospective study was conducted 938 patients who were recruited between February 2, 2008 March 11, 2013, with social characteristics history (duration...
Single-unit recordings were obtained from central vestibular neurons in three monkeys during passive head movements. Neurons that discharged relation to translation or changes orientation, but not eye movement ("vestibular-only," n = 154), examined detail. Neuronal discharge rates analyzed four stimulus conditions: sinusoidal the horizontal plane (0.2-4 Hz, 0.2 g peak acceleration), static tilt vertical (+/-20 degrees ), oscillatory (0.5-2 Hz), and angular rotation about an earth-vertical...
Recent work has demonstrated that transmembrane channel-like 1 protein (TMC1) is an essential component of the sensory transduction complex in hair cells inner ear. A closely related homolog, TMC2, expressed transiently neonatal mouse cochlea and can enable Tmc1-null mice during first postnatal week. Both TMC1 TMC2 are at adult stages vestibular cells. The extent to which substitute for each other unknown. Several biophysical differences between suggest these proteins perform similar but not...
Multiplicative computation is a basic operation that crucial for neural information processing, but examples of multiplication by pathways perform well-defined sensorimotor transformations are scarce. Here in behaving monkeys, we identified vestibular and eye position signals the vestibulo-ocular reflex (VOR). Monkeys were trained to maintain fixation on visual targets at different horizontal locations received brief unilateral acoustic clicks (1 ms, rarefaction, 85 approximately 110 db NHL)...