A5100361138- Sodium Intake and Health
- Ion Channels and Receptors
- RNA Research and Splicing
- Estrogen and related hormone effects
- Thermoregulation and physiological responses
- RNA modifications and cancer
- Planarian Biology and Electrostimulation
- Nutritional Studies and Diet
- Tuberculosis Research and Epidemiology
- Diet and metabolism studies
- Neurobiology and Insect Physiology Research
- Diet, Metabolism, and Disease
- BRCA gene mutations in cancer
- Ion Transport and Channel Regulation
- Neuroscience and Neural Engineering
- Metabolism, Diabetes, and Cancer
- PARP inhibition in cancer therapy
- Cancer-related gene regulation
- Plant and Biological Electrophysiology Studies
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacovigilance and Adverse Drug Reactions
- Biochemical Analysis and Sensing Techniques
- Wound Healing and Treatments
- Circadian rhythm and melatonin
Huazhong University of Science and Technology
2025
Central Hospital of Wuhan
2025
State Council of the People's Republic of China
2025
Daping Hospital
2014-2024
Army Medical University
2014-2024
Nanjing Chest Hospital
2024
Nanjing Brain Hospital
2023-2024
Nanjing Medical University
2023-2024
Harbin Institute of Technology
2019-2022
Auburn University
2019-2022
Type 2 diabetes mellitus (T2DM) is rapidly prevailing as a serious global health problem. Current treatments for T2DM may cause side effects, thus highlighting the need newer and safer therapies. We tested hypothesis that dietary capsaicin regulates glucose homeostasis through activation of transient receptor potential vanilloid 1 (TRPV1)-mediated glucagon-like peptide-1 (GLP-1) secretion in intestinal cells tissues. Wild-type (WT) TRPV1 knockout (TRPV1(-/-)) mice were fed 24 weeks. was...
High salt intake is the leading dietary risk factor for cardiovascular diseases. Although clinical evidence suggests that high associated with nonalcoholic fatty liver disease, which an independent diseases, it remains elusive whether salt-induced hepatic damage leads to development of diseases.Mice were fed normal or high-salt diet 8 weeks determine effect loading on histological changes and blood pressure, withdrawal metformin treatment also conducted some diet-fed mice. Adeno-associated...
Background: Drug-induced interstitial lung disease (DILD) is an increasingly common cause of morbidity and mortality. However, due to the lack specificity, DILD detection remains unsolved public health challenge. Objectives: For first time, we aimed examine reports submitted Food Drug Administration (FDA) Adverse Event Reporting System (FAERS) identify demographic characteristics top drugs associated with at a group level (including age, sex, drug class, country stratification) individual...
Purpose: To investigate the potential association between serum concentrations of high mobility group protein B1 (HMGB1) and receptor for advanced glycation end-products (RAGE) in relation to occurrence restenosis following interventional therapy lower extremity vascular disease patients diagnosed with type 2 diabetes mellitus (T2DM). Patients Methods: From March 2023 January 2024, 96 T2DM who underwent 6-month follow-up our hospital were studied. divided into in-stent (ISR) (n=38)...
Abstract Background Altered adipokine secretion in dysfunctional adipose tissue facilitates the development of atherosclerotic diseases including lower extremity peripheral artery disease (PAD). Asprosin is a recently identified and displays potent regulatory role metabolism, but relationship between asprosin PAD remains uninvestigated. Methods 33 type 2 diabetes mellitus (T2DM) patients (DM), 51 T2DM with (DM + PAD) 30 healthy normal control (NC) volunteers were recruited blood samples...
Background and Purpose— Previous studies show that endothelial nitric oxide synthase (eNOS) plays a prominent role in maintaining cerebral blood flow preventing stroke. Capsaicin hot pepper can increase the phosphorylation of eNOS cells. We test hypothesis chronic dietary capsaicin prevent stroke through activation cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels stroke-prone spontaneously hypertensive rats (SHRsp). Methods— SHRsp were fed capsaicin, their onset was...
Environmental cold is a nonmodifiable hypertension risk factor. Transient receptor potential melastatin subtype 8 (TRPM8) cold-sensing cation channel that can be activated by menthol, compound with naturally sensation in mint. Little known about the effect of TRPM8 activation on vascular function and blood pressure. Here, we report abundantly expressed vasculature. menthol attenuated vasoconstriction via RhoA/Rho kinase pathway inhibition wild-type mice, but was absent −/− mice. Chronic...
Abstract Migration of epidermal stem cells ( EpSCs ) into wounds may play an important role in wound healing. Endogenous electric fields EFs arise naturally at wounds. Consistent with previous reports, we measured outward currents rat skin using vibrating probes. Topical use prostaglandin E2 significantly promoted However, it is not known whether respond to . We first isolated and characterized from skin. then demonstrated that the epidermis migrated directionally toward cathode 50–400 mV...
Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, stomach cancers. Accumulating evidence suggests inherited genetic lung cancer. The present study aimed survey prevalence of pathogenic germline BRCA mutations (gBRCAm) explore potential association between gBRCAm disease onset Chinese advanced non-small cell (NSCLC) patients.A total 6,220 NSCLC patients were...
High salt (HS) intake contributes to the development of hypertension. Epithelial sodium channels play crucial roles in regulating renal reabsorption and blood pressure. The transient receptor potential vanilloid 1 (TRPV1) cation channel can be activated by its agonist capsaicin. However, it is unknown whether dietary factors act on urinary excretion epithelial (ENaC) function. Here, we report that TRPV1 activation capsaicin increased through reducing wild-type (WT) mice a HS diet but not...
Hypertension-induced renal fibrosis contributes to the progression of chronic kidney disease, and apigenin, an anti-hypertensive flavone that is abundant in celery, acts as agonist transient receptor potential vanilloid 4 (TRPV4). However, whether apigenin reduces hypertension-induced fibrosis, well underlying mechanism, remains elusive. In present study, deoxycorticosterone acetate (DOCA)-salt hypertension model was established male Sprague-Dawley rats were treated with or vehicle for...
Background Environmental cold‐induced hypertension is common, but how to treat remains an obstacle. Transient receptor potential melastatin subtype 8 (TRPM8) a mild cold‐sensing nonselective cation channel that activated by menthol. Little known about the effect of TRPM8 activation menthol on mitochondrial Ca 2+ homeostasis and vascular function in hypertension. Methods Results Primary smooth muscle cells from wild‐type or Trpm8 −/− mice were cultured. In vitro, we confirmed sarcoplasmic...
Background: Non-small-cell lung cancer (NSCLC) with STK11 mutation showed primary resistance to immune checkpoint inhibitors (ICIs). The glucose-lowering drug metformin exerted anti-cancer effect and enhanced efficacy of chemotherapy in NSCLC KRAS/STK11 co-mutation, yet it is unknown whether may enhance ICI mutant NSCLC. Methods: We studied the impact on vitro vivo using colony formation assay, cell viability Ki67 staining, ELISA, CRISPR/Cas9-mediated knockout, animal experiments. Results:...
Background Salt-sensitive hypertension is highly prevalent and associated with cardiorenal damage. Large clinical trials have demonstrated that SGLT2 (sodium-glucose cotransporter 2) inhibitors exert hypotensive effect protective benefits in patients without diabetes. However, the underlying mechanism remains elusive. Methods Results Dahl salt-sensitive rats salt-insensitive controls were fed 8% high-salt diet some of them treated canagliflozin. The blood pressure, urinary sodium excretion,...
Background: No effective sodium-reduction models targeting discretionary sources have been widely adopted. This study evaluates the scalability of an innovative primary school health education program delivered through School-Student-Family (SSF) route.Methods: The evolving SSF interventions were assessed based on three 1:1 cluster-randomized controlled trials (School-EduSalt, AppSalt, and EduSaltS-trial) one scaling initiative (EduSaltS) in China. comprised school-delivered, family-engaged...
Background We investigated the hypothesis that favorable effects of gastrointestinal ( GI ) intervention on hypertension HTN and cardiovascular CV disturbances are mediated by antagonizing overdrive sympathetic nervous system SNS ). Methods Results Hypertensive patients with metabolic underwent laparoscopic Roux‐en‐Y gastric bypass surgery, spontaneously hypertensive rats SHR s) RYGB or sham surgery. Blood pressure BP ), heart rate HR endothelium‐dependent flow‐mediated dilation,...
Abstract High salt intake is a major risk factor for hypertension. Although acute caffeine produces moderate diuresis and natriuresis, increases the blood pressure (BP) through activating sympathetic activity. However, long-term effects of on urinary sodium excretion are rarely investigated. Here, we investigated whether chronic administration antagonizes sensitive hypertension by promoting excretion. Dahl salt-sensitive (Dahl-S) rats were fed with high diet or without 0.1% in drinking water...
High-salt diet is an important risk factor for several non-communicable diseases. School-based health education has been found effective in reducing salt intake among children and their families China. However, no such interventions have scaled up the real world. For this purpose, a study was launched to support development scale-up of mHealth-based system (EduSaltS) that integrated routine reduction delivered through primary schools. This aims elaborate framework, process, features,...