A5087879785- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Natural product bioactivities and synthesis
- Immune cells in cancer
- Dam Engineering and Safety
- Respiratory Support and Mechanisms
- Phagocytosis and Immune Regulation
- Geotechnical Engineering and Underground Structures
- Grouting, Rheology, and Soil Mechanics
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Autophagy in Disease and Therapy
- Vagus Nerve Stimulation Research
- Immune Response and Inflammation
- PI3K/AKT/mTOR signaling in cancer
- interferon and immune responses
- Lung Cancer Research Studies
- Advanced Nanomaterials in Catalysis
- Ginseng Biological Effects and Applications
- NF-κB Signaling Pathways
- Drilling and Well Engineering
- RNA modifications and cancer
- Photodynamic Therapy Research Studies
Army Medical University
2018-2025
Daping Hospital
2022-2025
Shanghai East Hospital
2024-2025
Peking University
2022-2025
Peking University Cancer Hospital
2022-2025
Southwest Hospital
2024
Xinqiao Hospital
2018-2023
Zhejiang Ocean University
2018-2021
Harbin Medical University
2018
DNA nanostructures as scaffolds for drug delivery, biosensing, and bioimaging are hindered by its vulnerability in physiological settings, less favorable of incorporating arbitrary guest molecules other desirable functionalities. Noncanonical self-assembly with small an alternative system is attractive strategy to expand their applications multidisciplinary fields rarely explored. This work reports a nitrogen-enriched carbon dots (NCDs)-mediated nanostructure strategy. Given the excellent...
Abstract Background Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common acute failure due to diffuse pulmonary inflammation and oedema. Elaborate regulation of macrophage activation essential for managing this inflammatory process maintaining tissue homeostasis. In the past decades, metabolic reprogramming macrophages has emerged as predominant role in modulating their biology function. Here, we observed reduced expression carnitine palmitoyltransferase 1A (CPT1A),...
Programmable DNA nanostructure self-assembly offers great potentials in nanomedicine, drug delivery, biosensing, and bioimaging. However, due to the intrinsically negatively charged backbones, instability of nanostructures physiological settings poses serious challenges their practical applications. To overcome this challenge, a strategy that combines magnesium-free functionalization is proposed study. We hypothesize naturally abundant spermidine may not only mediate nanostructures, but also...
Acute lung injury (ALI) is characterized by severe inflammation and damage to the air-blood barrier, resulting in respiratory function life-threatening outcomes. Macrophage polarization plays an essential role occurrence, development, outcome of ALI. As drug carriers, self-assembled DNA nanostructures can potentially overcome drawbacks limitations traditional anti-inflammatory agents owing their nontoxicity, programmability, excellent structural control at nanoscale. A small interfering RNA...
Background: Non-small-cell lung cancer (NSCLC) with STK11 mutation showed primary resistance to immune checkpoint inhibitors (ICIs). The glucose-lowering drug metformin exerted anti-cancer effect and enhanced efficacy of chemotherapy in NSCLC KRAS/STK11 co-mutation, yet it is unknown whether may enhance ICI mutant NSCLC. Methods: We studied the impact on vitro vivo using colony formation assay, cell viability Ki67 staining, ELISA, CRISPR/Cas9-mediated knockout, animal experiments. Results:...
High-mobility group box 1 (HMGB1) protein can impair phagocyte function by suppressing the macrophage-mediated clearance of apoptotic cells (ACs), thereby delaying inflammation resolution in lungs and allowing progression acute lung injury (ALI) respiratory distress syndrome (ARDS). However, precise mechanism underlying this HMGB1-mediated inhibition efferocytosis remains unknown. The aim study was to determine effect HMGB1 on efferocytosis. We discovered that prevented bone marrow-derived...
Acute respiratory distress syndrome (ARDS) is an inflammatory disorder of the lungs caused by bacterial or viral infection. Timely phagocytosis and clearance pathogens macrophages are important in controlling inflammation alleviating ARDS. However, precise mechanism macrophage remains to be explored. Here, we show that expression Rab26 increased Escherichia coli ‐ Pseudomonas aeruginosa ‐stimulated bone marrow‐derived macrophages. Knocking out reduced interacts with mitochondrial fusion...
Introduction Lorlatinib, a third-generation ALK inhibitor, has demonstrated strong efficacy in treating advanced ALK-positive NSCLC, though real-world data, particularly from China, are limited. This study evaluates the and safety of lorlatinib Chinese patients with NSCLC. Materials methods retrospective analyzed 65 NSCLC who received at Peking University Cancer Hospital between September 2017 August 2024. The assessed overall response rate (ORR), progression-free survival (PFS), outcomes,...
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a condition with an imbalanced inflammatory response and delayed resolution of inflammation. Macrophage polarization plays important role in inflammation resolution. However, the mechanism macrophage ALI/ARDS not fully understood. We found that mice lipopolysaccharide administration developed accumulation extracellular cold-inducible RNA-binding protein (eCIRP) lungs. eCIRP, as damage-associated molecular pattern (DAMP),...
Background and Aims: Patients with aggressive hepatocellular carcinoma (HCC) have limited therapeutic options. Therefore, a better understanding of HCC pathogenesis is needed to improve treatment. Genomic studies improved our cancer biology. However, the ubiquitomic characteristics remain poorly understood. We aimed reveal provide clinical feature biomarkers that may be used for diagnosis or therapy in clinic. Approach Results: The comprehensive proteomic, phosphoproteomic, analyses were...
Complexing self-assembled DNA nanostructures with various functional guest species is the key to unlocking new and exciting biomedical applications. Cationic not only induce magnesium-free self-assemble into defined structures but also endow final complex nanomaterials properties. Herein, we propose a novel strategy that employs naturally occurring cationic amino acids self-assembly nanostructures. Natural l-arginine l-lysine can readily assembly of tile-based nanotubes origami sheets in...
Currently, a single treatment is less effective for triple-negative breast cancer (TNBC) therapy. Additionally, there are some limitations to the use of siRNA alone as new method treat cancer, such its delivery into cells. In this study, we proposed strategy that combines siRNA-loaded DNA nanostructure and genistein TNBC Both CD36 self-assembled nanoprisms (NP-siCD36) knocked down CD36, resulting in enhanced anticancer efficacy through phosphorylation p38 MAPK pathway.In vitrostudies showed...
Lorlatinib is a promising third-generation anaplastic lymphoma kinase (ALK) tyrosine inhibitor (TKI) that has been approved for treating ALK-positive non-small-cell lung cancer (NSCLC) patients with previous ALK-TKI treatment failures. However, the inevitable emergence of acquired resistance limits its long-term efficacy. A more comprehensive understanding mechanisms to lorlatinib will enable development efficacious therapeutic strategies. The efficacy chloroquine (CQ) in combination NSCLC...
Abstract Background Circulating tumor DNA (ctDNA) has made a breakthrough as an early biomarker in operable early‐stage cancer patients. However, the function of ctDNA combined with cell‐free (cfDNA) predictor advanced non‐small cell lung (NSCLC) remains unknown. Here, we explored its potential for predicting efficacy epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) patients NSCLC. Methods A retrospective analysis was undertaken. Plasma collected from 51 NSCLC prior to...
Overcoming cisplatin-based drug resistance in lung cancer remains an enormous challenge clinical tumor therapy worldwide. Recent studies have reported that some Rab GTPases are involved multiple aspects of progression, including invasion, migration, metabolism, autophagy, exosome secretion, and resistance. In particular, Rab26 is essential to vital processes such as vesicle-mediated cell growth, apoptosis, autophagy. this study, we developed a nanosystem based on programmed DNA self-assembly...
Abstract Herein, a strategy is proposed to simultaneously deliver the small-molecule drug metformin and siRNA with self-assembled DNA nanostructures. The biomedical application of nanostructures highly promising but still in its infancy. as delivery vehicles are conventionally synthesized magnesium-containing buffer. We propose using an anticancer assemble them for synergistic therapy. cargo induces self-assembly into well-defined, uniform nanostructures, producing drug–DNA nanocomplex...