A5101895663- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- MicroRNA in disease regulation
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone health and treatments
- Genetic Associations and Epidemiology
- Rheumatoid Arthritis Research and Therapies
- Mycobacterium research and diagnosis
- Bioinformatics and Genomic Networks
- Cancer Genomics and Diagnostics
- RNA and protein synthesis mechanisms
- Gut microbiota and health
- Birth, Development, and Health
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Muscle metabolism and nutrition
- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
- Icing and De-icing Technologies
- NF-κB Signaling Pathways
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
Peking University Third Hospital
2008-2025
Peking University
2008-2025
Soochow University
2017-2023
Shanxi Medical University
2021
Tulane University
2020
State Key Laboratory of Pharmaceutical Biotechnology
2019
Nanjing University
2019
Second Affiliated Hospital of Guangzhou Medical University
2015
Guangzhou Medical University
2015
Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by infiltration of immune cells in the synovium. However, crosstalk and synovial fibroblasts still largely unknown. Here, global miRNA screening plasma exosomes was carried out with a custom microarray (RA patients vs. healthy controls = 9:9). A total 14 exosomal miRNAs were abnormally expressed RA patients. Then, downregulated expression miR-204-5p confirmed both replication 30:30) validation groups 56:60). Similar to...
Aim: To identify sets of functionally related long noncoding RNAs (lncRNAs) and mRNAs to evaluate the importance lncRNAs in an lncRNA–mRNA network. Methods: We carried out weighted gene co-expression network analysis enrichment analyses functional modules co-expressed human peripheral blood mononuclear cells 43 females. Results: identified seven found hub each module. Four had significant ontology enrichments. Some (e.g., SSX8, UCA1, HOXA-AS2, STARD4-AS1 PCBP1-AS1) have known functions with...
Genetic variants have potential influence on DNA methylation and thereby regulate mRNA expression. This study aimed to comprehensively reveal the relationships among SNP, mRNA, identify methylation-mediated regulation patterns in human peripheral blood mononuclear cells (PBMCs). Based in-house multi-omics datasets from 43 Chinese Han female subjects, genome-wide association trios were constructed by simultaneously testing following three pairs: SNP-methylation, methylation-mRNA SNP-mRNA....
Abstract PBMCs are essential for immunity and involved in various diseases. To identify genetic variations contributing to transcriptome‐wide gene expression, we performed a genome‐wide eQTL analysis by using SNPs data mRNA expression data. assess whether there common regulation patterns shared among different tissues/organs, public datasets were utilized eQTLs with lymphoblastoid, monocytes, liver, brain. Allelic imbalance (AEI) assay was employed validate representative identified. We...
Aim: To identify epigenetically regulated network of genes in peripheral blood mononuclear cells significant for rheumatoid arthritis (RA). Methods: Differentially expressed (DEGs) and their associated differentially miRNAs methylated positions (DMPs) were identified. Causal inference test (CIT) identified the causal regulation chains. The analyses, example, weighted gene co-expression (WGCNA), protein–protein interaction functional enrichment, evaluated patterns among DEGs epigenetic...
Aim: To detect SNP-miRNA-mRNA interaction networks and to elucidate miRNA-mediated regulation effects on mRNA expression. Materials & methods: In human peripheral blood mononuclear cells of 43 females, were established through an integrative analysis. Then causal inference test was followed expressions. Results: About 167 trios corresponding 56 SNPs, 20 miRNAs 47 target-mRNAs have the interactions, but only 22 between SNP mRNA. For three (hsa-miR-222–3p, hsa-miR-181b-5p hsa-miR-106b-5p),...
While osteoimmunology interactions between the immune and skeletal systems are known to play an important role in osteoblast development, differentiation bone metabolism related disease like osteoporosis, such either microenvironment or peripheral circulation vivo at single-cell resolution have not yet been characterized. We explored communications cells osteoblastic lineage (OBCs) by performing CellphoneDB CellChat analyses with RNA sequencing (scRNA-seq) data from human femoral head. also...
Genome-wide association studies (GWASs) routinely identify loci associated with risk factors for osteoporosis. However, GWASs relatively small sample sizes still lack sufficient power to ascertain the majority of genetic variants modest effect size, which may together truly influence phenotype. The identified only account a percentage heritability This study aims novel DXA-derived femoral neck (FNK) bone mineral density (BMD) and quantitative ultrasound heel calcaneus estimated BMD (eBMD),...
To the Editor: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by symmetric polyarthritis and presence of autoantibodies. Recent studies have shown that blood not as sterile previously supposed,1, 2 microbial dysbiosis implicated in pathogenesis some diseases,2, 3 but reported RA. Our identified RA-associated interferon-inducible gene network has strongly circulation probably served an important environmental factor.4 identify alterations circulating...
Abstract A large number of SNP s significant for osteoporosis ( OP ) had been identified by genome‐wide association studies. However, the underlying mechanisms were largely unknown. From perspective protein phosphorylation, gene expression regulation, and bone cell activity, this study aims to illustrate representative interest. We utilized public databases bioinformatics tool identify ‐associated which potentially influence phosphorylation (phos s). Associations with hip/spine BMD , as well...
Personalized medicine becomes an area of great interest following the recent development in human genetics, proteomics and metabolomics. There is increasing need to embed scientific discoveries from basic medical research into real life clinical practices, such that a patient's biological traits can be used facilitate treatment. Those individualized traits, termed as biomarkers, are actively involved developing personalized therefore bring out challenges trial designs. The necessity...