A5101452804- Cancer-related molecular mechanisms research
- Stroke Rehabilitation and Recovery
- Diabetic Foot Ulcer Assessment and Management
- MicroRNA in disease regulation
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Ovarian function and disorders
- Cancer Treatment and Pharmacology
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genetic Associations and Epidemiology
- Nuclear Receptors and Signaling
- Reproductive Biology and Fertility
- Cancer, Hypoxia, and Metabolism
- Acute Ischemic Stroke Management
- Cancer, Lipids, and Metabolism
- Autoimmune and Inflammatory Disorders Research
- Gene expression and cancer classification
- Bone and Joint Diseases
- Cytokine Signaling Pathways and Interactions
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
Nanjing University of Chinese Medicine
2011-2025
Nanjing Medical University
2025
Jiangsu Province Hospital
2023-2025
Central South University
2018-2024
West China Medical Center of Sichuan University
2023-2024
Shenzhen Children's Hospital
2024
Xiangya Hospital Central South University
2022-2023
Microsoft Research Asia (China)
2023
Tianjin Medical University General Hospital
2022
Tulane University
2020-2021
Osteonecrosis of the femoral head (ONFH) commonly occurs after glucocorticoid (GC) therapy. The gut microbiota (GM) participates in regulating host health, and its composition can be altered by GC. Here, this study demonstrates that cohousing with healthy mice or colonization GM from normal attenuates GC-induced ONFH. 16S rRNA gene sequencing shows rescues reduction Lactobacillus animalis. Oral supplementation L. animalis mitigates ONFH increasing angiogenesis, augmenting osteogenesis,...
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stromal that have a critical role in the maintenance of skeletal tissues such as bone, cartilage, and fat bone marrow.In addition to providing microenvironmental support for hematopoietic processes, BM-MSCs can differentiate into various mesodermal lineages including osteoblast/osteocyte, chondrocyte, adipocyte crucial metabolism.While high cell-to-cell heterogeneity gene expression, cell subtypes contribute this vivo...
Anthracycline drugs mainly include doxorubicin, epirubicin, pirarubicin, and aclamycin, which are widely used to treat a variety of malignant tumors, such as breast cancer, gastrointestinal lymphoma, etc. With the accumulation anthracycline in body, they can induce serious heart damage, limiting their clinical application. The mechanism by cause cardiotoxicity is not yet clear. This review provides an overview different types cardiac damage induced anthracycline-class delves into molecular...
Osteoporosis is characterized by low bone mineral density (BMD). The advancement of high-throughput technologies and integrative approaches provided an opportunity for deciphering the mechanisms underlying osteoporosis. Here, we generated genomic, transcriptomic, methylomic, metabolomic datasets from 119 subjects with high (n = 61) 58) BMDs. By adopting sparse multiple discriminative canonical correlation analysis, identified optimal multi-omics biomarker panel 74 differentially expressed...
The homeostasis of bone metabolism depends on the coupling and precise regulation various types cells in tissue. However, communication interaction between tissue at single-cell level remains poorly understood. Thus, we performed RNA sequencing (scRNA-seq) primary human femoral head (FHTCs). Nine cell were identified 26,574 FHTCs, including granulocytes, T cells, monocytes, B red blood osteoblastic lineage endothelial progenitor (EPCs) plasmacytoid dendritic cells. We
Background: Type 2 diabetes afflicts 95% of patients. Recent data suggest that miRNAs play a key role in insulin production, secretion and function. This study aims to explore the specific miR-499-5p hepatic resistance. Methods: The miRNA expression levels livers db/db mice were analyzed using chips verified by real-time PCR. mimics an inhibitor transfected into NCTC1469 cells. Then, PI3K/AKT signaling pathway glycogen level determined. target genes predicted bioinformatics then confirmed...
Obesity is now a common risk factor for non-alcoholic fatty liver disease (NAFLD). Thus, it important to explore its underlying mechanisms.Total RNA was extracted from peripheral whole blood samples 50 NAFLD patients and healthy controls. In addition, human specimens were obtained through biopsies The level of miRNA studied using real-time PCR. expression lipogenic genes analyzed western blot, dual luciferase reporter assay conducted identify the possible target gene. Adenovirus vectors...
Human osteoblasts are multifunctional bone cells, which play essential roles in formation, angiogenesis regulation, as well maintenance of hematopoiesis. However, the categorization primary osteoblast subtypes
Idiopathic pulmonary fibrosis (IPF) can severely disrupt lung function, leading to fatal consequences, and there is currently a lack of specific therapeutic drugs. Bergenin an isocoumarin compound with lots biological functions including antioxidant activity. This study evaluated the potential beneficial effects bergenin on investigated possible mechanisms. We found that alleviated bleomycin-induced by relieving oxidative stress, reducing deposition extracellular matrix (ECM) inhibiting...
Although significant progress has been made in understanding the mechanisms of steatosis and insulin resistance, physiological functions regulators these processes remain largely elusive. Evidence suggested that glutamate/N-methyl-D-aspartic acid receptor (NMDAR) axis contributes to acute lung injury, pulmonary arterial hypertension, diabetes, but specific metabolic contribution glutamate/NMDAR is not clear. Here we provide data at animal, cellular, molecular levels support role as a...
Abstract Current treatments for neuropathic pain are suboptimal, necessitating the search more effective therapeutics. Our previous study showed that inhibition of neuroinflammation in spinal cord induced analgesic effects, and focal repetitive trans-spinal magnetic stimulation an anti-neuroinflammatory effect injury rat models. Here, we speculated might induce anti-inflammatory to alleviate by upregulating calmodulin-dependent protein kinase beta (CaMKKβ)/adenosine...
The role of Ras guanine nucleotide-releasing protein 1 (RasGRP1) in tumourigenesis has been a subject debate, and its functions clinical significance hepatocellular carcinoma (HCC) remain unknown. Here, we evaluated the expression RasGRP1 HCC determined how it contributes to cell proliferation.RasGRP1 was measured by quantitative polymerase chain reaction (qPCR) Western blotting 24 paired tissues para-tumour tissues. confirmed immunohistochemical analysis tissue microarray from independent...
Abstract Tamoxifen resistance (TamR) prevents ER-positive breast cancer patients from benefitting endocrine therapy, and miR-221 or miR-222 plays vital roles in inducing TamR. In this study, we designed synthetic sponges to reverse TamR by targeting these two miRs. First, established a tamoxifen resistant cell line (MCF-7 ), verified the high expressing level of miRs cells. inhibitors rendered MCF-7 cells responsive tamoxifen. Next, miR-221/222 sponge, which contains total 8 multi-antisense...
The integration of biomolecular modeling with natural language (BL) has emerged as a promising interdisciplinary area at the intersection artificial intelligence, chemistry and biology. This approach leverages rich, multifaceted descriptions biomolecules contained within textual data sources to enhance our fundamental understanding enable downstream computational tasks such biomolecule property prediction. fusion nuanced narratives expressed through structural functional specifics described...
Endothelial cells (ECs) and bone marrow stromal (BMSCs) play crucial roles in supporting hematopoiesis hematopoietic regeneration. However, whether ECs are a source of BMSCs remains unclear. Here, we evaluate the contribution endothelial-to-mesenchymal transition to BMSC generation postnatal mice. Single-cell RNA sequencing identifies expressing markers Prrx1 Lepr; however, this could not be validated using Prrx1-Cre Lepr-Cre transgenic Additionally, only minority marked by EC lineage...
[Purpose] To evaluate the feasibility and efficacy of adapted low intensity ergometer aerobic training for early severely impaired stroke survivors. [Subjects] The subjects were forty-eight [Methods] Eligible recruited randomly assigned to an experimental group a control group. Both groups participated in comprehensive rehabilitation training. Low was only performed by Outcome measures Fugl-Meyer motor score, Barthel index, exercise test time, peak heart rate, plasma glucose level serum...
Reprogramming of cellular metabolism is one the hallmarks for cancer, in which tumor cells rewire their metabolic fluxes to generate sufficient energy and biosynthetic intermediates. Therefore, elucidating correlation between hepatocellular carcinoma (HCC) progression may provide insights into novel approaches cancer therapy.
Abstract Idiopathic pulmonary fibrosis treatments are limited, often with severe side effects, highlighting the need for novel options. Taraxerone has diverse biomedical properties, but its mechanism remains unclear. This study investigates taraxerone's impact and mechanisms involved in bleomycin‐induced mice. After establishing a mouse model, taraxerone was intraperitoneally injected continuously 14–28 days. The vivo antifibrotic antioxidative stress effects of were assessed. In vitro,...
BACKGROUND The current study aims to investigate the expression and significance of lncRNA PANDAR in serum patients with type II diabetes mellitus (T2DM) diabetic nephropathy (DN). METHODS 77 T2DM patients, 60 DN healthy controls was detected by RT-PCR. Pearson's correlation assay carried out analyze between clinical indicators. Receiver operator characteristic (ROC) analysis diagnostic value patients. RESULTS significantly higher than that control group. Moreover, massive proteinuria...