A5100370696- Statistical Methods and Inference
- Statistical Methods in Clinical Trials
- Renal Transplantation Outcomes and Treatments
- Advanced Causal Inference Techniques
- Organ Transplantation Techniques and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods and Bayesian Inference
- COVID-19 epidemiological studies
- Transplantation: Methods and Outcomes
- Statistical Distribution Estimation and Applications
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Optimal Experimental Design Methods
- Photodynamic Therapy Research Studies
- Lung Cancer Treatments and Mutations
- Advanced X-ray and CT Imaging
- MicroRNA in disease regulation
- Polyomavirus and related diseases
- Disaster Response and Management
- Geochemistry and Geochronology of Asian Mineral Deposits
- Cytomegalovirus and herpesvirus research
- Cancer Genomics and Diagnostics
- Neurological Complications and Syndromes
- Organ Donation and Transplantation
- Cancer Risks and Factors
Southern Medical University
2016-2025
Second Affiliated Hospital of Guangzhou Medical University
2019-2025
Guangzhou Medical University
2016-2025
Guangdong Academy of Medical Sciences
2024-2025
Guangdong Provincial People's Hospital
2024-2025
Nanfang Hospital
2000-2024
Union Hospital
2024
Jilin University
2024
National Medical Products Administration
2024
Jiangxi Agricultural University
2023
As the competition of Web search market increases, there is a high demand for personalized to conduct retrieval incorporating users' information needs. This paper focuses on utilizing clickthrough data improve search. Since millions searches are conducted everyday, engine accumulates large volume data, which records who submits queries and pages he/she clicks on. The highly sparse contains different types objects (user, query page), relationships among these also very complicated. By...
A common problem that is encountered in medical applications the overall homogeneity of survival distributions when two curves cross each other. survey demonstrated under this condition, which was an obvious violation assumption proportional hazard rates, log-rank test still used 70% studies. Several statistical methods have been proposed to solve problem. However, many applications, it difficult specify types differences and choose appropriate method prior analysis. Thus, we conducted...
This study estimated case fatality rates in Hong Kong, Singapore and Beijing using the number of new admissions, deaths discharges by cure. To determine relationships between hazard for death that cure, a cure--death plot was developed. The daily ratios two hazards ultimate rate. rate approximately 18% Kong Singapore, while exceeded 52% until 5 May, 16% 5-19 4%-1% after 20 May. These results show significant difference other areas, which seems to have been due treatment methods. That is, it...
Calcium-permeable ionotropic NMDAR-mediated hyperactivity is regarded as the critical factor in modulating development of ischaemic stroke. Recently, there has been increasing interest preventing post-stroke neuronal death by focusing on intervening function subpopulations NMDARs and their downstream signalling. Geniposide, an iridoid glycoside, found to have cytoprotective functions various conditions. However, it still unclear whether how geniposide affects insult under experimental...
The proportional hazards (PH) assumption is often violated in clinical trials. If the most commonly used Log-rank test for trial design non-proportional hazard (NPH) cases, it will result power loss or inflation, and effect measures ratio become difficult to interpret. To circumvent issue caused by NPH make easy interpret communicate, two simulation-free methods about restricted mean survival time group sequential (GS-RMST) are introduced this study: independent increment GS-RMST (GS-RMSTi)...
<title>Abstract</title> <bold>Background</bold>: Delayed graft function (DGF) increases the renal allograft failure risk. The objective of this study was to estimate incidence CMV infection and analyze whether DGF is associated with an increased risk infection. <bold>Methods</bold>: This single center, retrospective, cohort deceased donor transplant recipients assessed outcomes in patients experiencing versus those without DGF. Univariate multivariate hazard ratios were calculated a Cox...
Abstract Photodynamic immunotherapy presents a non‐invasive strategy characterized by spatiotemporal control and minimal side effects to induce immunogenic cell death (ICD). This approach significantly enhances the release of tumor‐associated antigens damage‐associated molecular patterns, thereby improving cancer outcomes. However, hypoxia antioxidant defenses at tumor sites considerably diminish efficacy photodynamic immunotherapy. In this work, covalent warhead, alkyneamide, is introduced...
Pulmonary hypertension (PH) is a severe cardiovascular complication of bronchopulmonary dysplasia (BPD) that contributes to the high mortality rates for preterm infants. The objective this study establish prediction model BPD-associated PH (BPD-PH) by integrating multiple predictive factors infants with BPD.A retrospective investigation perinatal clinical records and data echocardiography in all BPD was performed from January 2012 December 2019. A BPD-PH established based on univariate...
In clinical or epidemiological follow‐up studies, methods based on time scale indicators such as the restricted mean survival (RMST) have been developed to some extent. Compared with traditional hazard rate indicator system methods, RMST is easier interpret and does not require proportional assumption. To date, regression models are indirect direct of baseline covariates. However, time‐dependent covariates becoming increasingly common in studies. Based inverse probability censoring weighting...
Background: For patients with prostate cancer (PCa), the presence of pelvic lymph node metastasis (LNM) is a strong predictor poor outcome. However, approaches promising sensitivity and specificity to detect LNM are still lacking. We investigated value collapsin response mediator protein 4 (CRMP4) promoter methylation in biopsies as for LNM. Methods:CRMP4 at two previously identified CpG sites was determined 80 case-matched biopsy samples (the training set) using bisulfite pyrosequencing....
This study explored the prognostic factors and developed a prediction model for Chinese-American (CA) cervical cancer (CC) patients. We compared two alternative models (the restricted mean survival time (RMST) proportional baselines landmark supermodel (PBLS model, producing dynamic prediction)) versus Cox hazards in context of time-varying effects. A total 713 CA women with CC available covariates (age at diagnosis, International Federation Gynecology Obstetrics (FIGO) stage, lymph node...
Abstract In clinical and epidemiologic studies, hazard ratios are often applied to compare treatment effects between 2 groups for survival data. For competing-risks data, the corresponding quantities of interest cause-specific subdistribution ratios. However, they both have some limitations related model assumptions interpretation. Therefore, we recommend restricted mean time lost (RMTL) as an alternative measure that is easy interpret in a framework. Based on difference RMTL (RMTLd),...
Statistical analysis is critical in medical research. The objective of this article to summarize the appropriate use and reporting commonly used statistical methods research, on basis existing guidelines authors’ experience reviewing manuscripts, provide recommendations for applications reporting.
Background Kidneys obtained from deceased donors increase the incidence of delayed graft function (DGF) after renal transplantation. Here we investigated influence risk factors with DGF, and developed a donor scoring system for DGF prediction.Methods This retrospective study was conducted in 1807 kidney 3599 recipients who received kidneys via transplants 29 centers China. We quantified associations clinical characteristics. A validated using an independent sample set.Results The 19.0%. Six...
Purpose To construct a dynamic prediction model for BK polyomavirus (BKV) reactivation during the early period after renal transplantation and to provide statistical basis identification of intervention high-risk populations. Methods A retrospective study 312 first allograft recipients with strictly punctual follow-ups was conducted between January 2015 March 2022. The covariates were screened using univariable time-dependent Cox regression, those P&lt;0.1 included in static analyses. We...
To explore the etiology of risk factors and quantify mortality differences in systemic lupus erythematosus (SLE) patients with different initial disease activity. The Jiangsu Lupus database was established by collecting medical records from first-hospitalized SLE during 1999-2009 26 centers province, China, their survival status every five years. SLEDAI scores [high (>12) vs. low-moderate (≤12)] attributable to were quantified using population fraction (PAF), relative (RAR) adjusted (ARR)....
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting motor neurons, with broad heterogeneity in progression and survival different patients. Therefore, an accurate prediction model will be crucial to implement timely interventions prolong patient time.A total of 1260 ALS patients from the PRO-ACT database were included analysis. Their demographics, clinical variables, death reports included. We constructed dynamic Cox through landmarking approach. The predictive...
Early oral intake is strongly recommended according to the enhanced recovery after surgery (ERAS) guidelines because it can reduce complications and improve recovery. However, early has been indicated be associated with chyle leakage (CL) pancreatic surgery, which may lead worsening of existing malnutrition impeded This study investigated relationship between CL identified risk factors for its occurrence promote pancreaticoduodenectomy.All patients who underwent pancreaticoduodenectomy June...