A5100625085- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Ovarian function and disorders
- Peripheral Neuropathies and Disorders
- Rheumatoid Arthritis Research and Therapies
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Gynecological conditions and treatments
- Ovarian cancer diagnosis and treatment
- Cancer Mechanisms and Therapy
- Ectopic Pregnancy Diagnosis and Management
- Functional Brain Connectivity Studies
- Viral gastroenteritis research and epidemiology
- Adipose Tissue and Metabolism
- Uterine Myomas and Treatments
- Phytochemicals and Antioxidant Activities
- Monoclonal and Polyclonal Antibodies Research
- Lipid metabolism and disorders
- Endometrial and Cervical Cancer Treatments
- Berberine and alkaloids research
- Lipoproteins and Cardiovascular Health
- Cancer-related molecular mechanisms research
- Infection Control and Ventilation
- Lysosomal Storage Disorders Research
- Acute Ischemic Stroke Management
Yuhuangding Hospital
2010-2024
Qingdao University
2010-2024
Shaanxi University of Chinese Medicine
2024
Zhongda Hospital Southeast University
2008-2023
Baoding People's Hospital
2023
Guangdong University of Technology
2023
The Third People's Hospital of Dalian City
2017-2023
China National Center for Food Safety Risk Assessment
2021-2022
Central South University
2019-2022
Xiangya Hospital Central South University
2022
Inflammation is one of main mechanisms autoimmune disorders and a common feature most diseases. Appropriate suppression inflammation key resolution to treat the Sirtuin1 (Sirt1) has been shown play role in regulation inflammation. Resveratrol, potent Sirt1 activator, anti-inflammation property. However, detailed mechanism not fully understood. In this study, we investigated NIH/3T3 fibroblast cell line. Upregulation matrix metalloproteinases 9 (MMP-9), interleukin-1beta (IL-1β), IL-6...
Abstract Colorectal cancer is one of the most common causes cancer-related death in humans. Coptisine (COP) a natural alkaloid from Coptidis Rhizoma with unclear antitumor mechanism. Human colon cells (HCT-116) and xenograft mice were used to systematically explore anti-tumor activity COP this study. The results indicated that exhibited remarkably cytotoxic activities against HCT-116 by inducing G 1 -phase cell cycle arrest increasing apoptosis, preferentially inhibited survival pathway...
Objective. To investigate the mortality of hospitalized patients with systemic lupus erythematosus (SLE) and determine influential factors associated poor prognosis. Methods. Medical records 1956 SLE inpatients from 15 hospitals during period January 1, 1999, to December 31, 2009, were reviewed. All followed up in 2010. Potential analyzed, comparing who living those deceased. The independency significantly related death was determined by Cox regression analysis. Results. Male female ratio...
Abstract Insulin resistance (IR) is the main pathogenesis of metabolic syndrome and a shared pathophysiological change in conditions such as diabetes mellitus, adiposity, hypertension, atherosclerosis. Visceral adipose tissue-derived serpin (Vaspin) newly discovered adipocytokine with insulin-sensitizing anti-inflammatory effects. To examine if vaspin can improve insulin rats fed high-fat diet via receptor substrate/phosphatidylinositol 3 kinase/protein kinase B/glucose transport...
Objective To identify early signs associated with poor prognosis in Chinese patients systemic lupus erythematosus (SLE) through a large population-based follow-up study. Methods Medical records of > 2,500 SLE that first hospitalized between 1999–2009 were collected from 26 centers across Jiangsu province, China, and entered into database. These followed-up for 5 to 15 years, those remained contact had known survival status 2015 assessed the association factors presented at initial...
To compare the clinical outcomes of follicular versus luteal phase ovarian stimulation in women with poor response (Bologna criteria) undergoing IVF.This retrospective study investigated 446 patients submitted to 507 cycles three groups. First, two larger cohorts were examined: 154 treated (Group Lu); and 231 administered Fo). Then 61 double analyzed. Clinical included number retrieved oocytes, fertilization rate, cleavage top-quality embryo pregnancy rate (CPR), live birth (LBR).Longer...
Studies on clinical features of systemic lupus erythematosus among different age-onset patients are lacking in China. This multicentre study aimed to systemically compare manifestations, comorbidities, organ involvement, and laboratory findings 797 Chinese juvenile-onset, adult-onset, late-onset SLE (JSLE, ASLE, LSLE) patients. They were classified into JSLE, LSLE groups if first diagnosed at < 18, 18-50, > 50 years old, respectively. Chi-square test analysis variance employed for...
Numerous studies have investigated the differences in mean functional connectivity (FC) strength between amnestic mild cognitive impairment (aMCI) patients and normal subjects using resting-state magnetic resonance imaging.However, whether FC is increased, decreased or unchanged aMCI compared to controls remains unclear.Two factors might lead inconsistent results: determination of regions interest reliability FC.We explored degree centrality (Dc) constructed by bootstrap method, within...
Abstract Objective To evaluate the association and dose–response pattern between antimalarial drugs overall cause specific mortality in SLE patients. Methods Medical records including information on HCQ/chloroquine (CQ) prescription were extracted from Jiangsu Lupus database. The database was designed to collect data patients that first-hospitalized during 1999–2009 province, China, a follow-up for survival status performed 2010 2015. Cox restricted cubic spline models used estimate hazard...
Intrahepatic cholangiocarcinoma (ICC) is a relatively rare form of liver cancer with poor prognosis.The therapeutic options for patients advanced ICC are limited and usually ineffective.There currently no approved targeted therapy ICC, although accumulating evidence supports inhibition the PI3K/Akt/mTOR signaling pathway as promising strategy in treatment ICC.Here, we report patient stage IV harboring PIK3CA mutation who responded well to mTOR inhibitor everolimus.Computed tomography...
To explore the etiology of risk factors and quantify mortality differences in systemic lupus erythematosus (SLE) patients with different initial disease activity. The Jiangsu Lupus database was established by collecting medical records from first-hospitalized SLE during 1999-2009 26 centers province, China, their survival status every five years. SLEDAI scores [high (>12) vs. low-moderate (≤12)] attributable to were quantified using population fraction (PAF), relative (RAR) adjusted (ARR)....
Abstract Environmental exposures interact with genetic factors has been thought to influence susceptibility of systemic lupus erythematosus (SLE) development. To evaluate the effects environmental on SLE, we conducted a population-based cohort study across Jiangsu Province, China, examine associations between living environment including air and water pollution, population density, economic income level, etc. prevalence mortality hospitalized SLE (h-SLE) patients. A total 2231 h-SLE patients...
Infertility remains a significant global burden over the years. Reproductive surgery is an effective strategy for infertile women. Early prediction of spontaneous pregnancy after reproductive high interest patients seeking infertility treatment. However, there are no high-quality models and clinical applicable tools to predict probability natural conception surgery. The eligible data involving 1013 who operated between June 2016 2021 in Yantai Yuhuangding Hospital China, were randomly...
Most previous imaging studies have used traditional Pearson correlation analysis to construct brain networks. This approach fails adequately and completely account for the interaction between adjacent regions. In this study, we L1-norm linear regression model test small-world attributes of networks three groups patients, namely, those with mild cognitive impairment (MCI), Alzheimer's disease (AD), healthy controls (HCs); attempted identify method that may detect minor differences in MCI AD...
Explore the therapeutic role of human umbilical mesenchymal stem cells (hUMSCs) transplantation for regeneration ECM components and restoration follicular development in mice.The extracellular matrix (ECM) is crucial to maintain ovary function regulate development, as it participates important cell signaling provides physical support cells. However, unknown how hUMSCs affect expression ECM-related genes ovaries treated with cyclophosphamide (CTX) busulfan (BUS).In present study, we used 64...