Background Lingguizhugan decoction is a traditional Chinese medicine prescription that has been used to improve non-alcoholic fatty liver disease and its progressive form, steatohepatitis (NASH). However, the anti-NASH effects underlying mechanisms of remain unclear. Methods Male Sprague-Dawley rats were fed methionine- choline-deficient (MCD) diet induce NASH, then given orally for four weeks. NASH indexes evaluated by histopathological analysis biochemical parameters including serum...

Endovascular clot retrieval is a technique available for removing intracranial arterial occlusions in acute ischemic stroke (AIS). This rescue therapy can be performed with moderate conscious sedation (CS) or general anesthesia (GA). The effect of GA on clinical outcome AIS remains controversial. Therefore, we retrospectively investigated whether the use CS during endovascular intervention influenced outcomes.Patients who underwent emergent occlusion years 2006 to 2012 were included this...

In Brief BACKGROUND: The development of hyperalgesia and allodynia after chronic constrictive injury (CCI) is associated with significantly increased tumor necrosis factor (TNF)-α interleukin (IL)-1β. Theoretically, if the production TNF-α and/or IL-1β could be reduced, neuropathic pain syndrome may alleviated. Recently, a beneficial effect hyperbaric oxygenation therapy (HBOT) in treatment disorders has been suggested. Our present study was designed to examine hypotheses that (1)...

The usefulness of intraoperative neurophysiological monitoring (IONM), including somatosensory-evoked potential (SSEP) and transcranial electrical motor-evoked potentials (TcMEPs) in cervical spine surgery still needs to be evaluated. We retrospectively reviewed 200 patients from 2008 2009 determine the role IONM surgery. Total intravenous anesthesia was used for all patients. alerts were defined as a 50% decrease amplitude, 10% increase latency, or unilateral change SSEP an stimulation...

The aim of this study was to investigate the association between diabetes mellitus (DM), mainly type II, with metabolic syndrome (MS) and diabetic nephropathy (DN)/diabetic retinopathy (DR). Based on analysis prevalence MS, patients DM were divided into MS non-MS groups according presence or absence MS. correlation DN, DR certain factors, including gender, age, disease duration a family history analyzed. among 62.50%. DN 55.33% in group that 26.00%. positively correlated blood pressure,...

Mental time travel refers to the ability recall past events and imagine possible future events. Schizophrenia (SCZ) patients have problems in remembering specific personal experiences imagining what will happen future. This study aimed examine episodic thinking SCZ spectrum disorders including individuals with schizotypal personality disorder (SPD) proneness who are at risk for developing SCZ. Thirty-two patients, 30 SPD individuals, 33 healthy controls participated study. The Sentence...

Follicular atresia is one of the main processes for loss granulosa cells and oocytes from mammalian ovary any impairment to premature ovarian failure. Large numbers studies have demonstrated that cell apoptosis causes follicular atresia, yet rescue these remains elusive. We aimed use Esculentoside A (3-O-b-D-glucopyranosyl-1, 4-b-D-xylopyranosyl) phytolaccagenin, a saponin extracted Phytolacca esculenta roots, as potential agent cells. Our results revealed normal body weights,...

Some fruits after long-term fermentation have anti-obesity function, however, the mechanisms not been systematically determined. This study aimed to screen effective fermented and explore mechanisms. C57BL/6J male mice were fed with a high fat diet (HFD) establish an obese model intervened nine kinds of individually. Fermented significantly lowered body weight gain (BWG), average daily feed intake (ADFI) adipose tissue coefficient, attenuated hepatic steatosis. Serum triglyceride (TG) total...

AIM:To study the portal hemodynamics and their relationship with size of esophageal varices seen at endoscopy to evaluate whether these Doppler ultrasound parameters might predict variceal bleeding in patients liver cirrhosis hypertension. METHODS:One hundred twenty cirrhotic but without any previous were enrolled prospective study.During a 2-year observation period, 52 who had least one episode acute hemorrhage constituted group, remaining 68 non-bleeding group.All underwent before or after...

In Brief Objective: To evaluate the prevalence of atherosclerosis in Chinese premenopausal women with systemic lupus erythematosus (SLE) and study possible associations between traditional nontraditional risk factors premature atherosclerosis. Methods: We evaluated 111 SLE 40 healthy controls without clinical cardiovascular disease. B-mode ultrasound was used to measure carotid plaque intima-media wall thickness (IMT). The frequency for patients compared, relationship patients'...

The purpose of this study was to evaluate the usefulness real-time contrast-enhanced sonography and microvascular imaging for differential diagnosis neoplastic non-neoplastic polypoid lesions gallbladder.Real-time were performed in 128 patients with gallbladder larger than 6 mm diameter. enhancement patterns, types, kinetic parameters analyzed on sonography. maximum diameters measured by conventional also recorded subjected a comparative analysis.Among patients, histologic diagnoses obtained...

Theoretically, communication systems have the potential to increase productivity of anesthesiologists supervising anesthesia providers. We evaluated maximal care by enhancing anesthesiologists' coordination (activities) among operating rooms (ORs).At hospital A, data for 13,368 pages were obtained from files recorded in internal alphanumeric text paging system. Pages postanesthesia unit processed through a numeric system and thus not included. At B, different US state, 3 authors categorized...

Abstract Background and Aim Polypoid lesions of the gallbladder may be neoplastic or non‐neoplastic. Correct diagnosis would help reduce unnecessary cholecystectomies. This study aimed to determine predictive value individual ultrasound characteristics for polyps build a scoring system based on these characteristics. Methods A total 109 patients with ≥ 6 mm underwent conventional examination received finally by pathological examination. All images were analyzed lesions. Univariate...

To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats.Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 each group. The nephropathy model was constructed later 4 groups. Then, 3 groups treated with 2, 8 μg/kg for weeks, respectively. serum urine biochemical indexes oxidative stress inflammatory tissue determined.Compared to group, group fasting plasma glucose hemoglobin A1c levels...

ABSTRACT BACKGROUND Increasing attention has been paid to cardiac involvement in patients with coronavirus disease 2019 (COVID-19). Yet, scarce information is available regarding the morphological and functional features of impairments these patients. METHODS We conducted a prospective serial echocardiographic study investigate structural changes among COVID-19 admitted intensive care unit (ICU). From January 21 April 8, 2020, total 51 ICU (31 critically ill 20 severely ill) confirmed were...