A5008628300- Renal Transplantation Outcomes and Treatments
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cytomegalovirus and herpesvirus research
- Organ Donation and Transplantation
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Multiple Myeloma Research and Treatments
- RNA modifications and cancer
- MicroRNA in disease regulation
- Bladder and Urothelial Cancer Treatments
- Renal and Vascular Pathologies
- Antibiotic Resistance in Bacteria
- Genetic and Kidney Cyst Diseases
- Nuts composition and effects
- Cancer Genomics and Diagnostics
- Liver physiology and pathology
- Ziziphus Jujuba Studies and Applications
- Antifungal resistance and susceptibility
- Ureteral procedures and complications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Infections and bacterial resistance
- Lipid metabolism and biosynthesis
- Drug-Induced Adverse Reactions
- Urinary and Genital Oncology Studies
Shandong University
2014-2024
Shandong Provincial QianFoShan Hospital
2011-2022
Shandong First Medical University
2019-2020
Baylor College of Medicine
2006
Deep Candida albicans infection is one of the major causes death in immunosuppressed hosts. Remodeling macrophages to phenotype M1 can decrease fungus burden and facilitate combating C. under an immunosuppressive state. In this study, a nanotrinity was exploited direct fungicidal macrophage polarization by leveraging regulation pathways redifferentiation. Conventional chemotherapeutic imatinib, which abrogate M2 via "shutting off" STAT6 phosphorylation pathway, encapsulated biodegradable...
Background: Bladder cancer (BC) is among the most frequently occurring types in urinary system. In recent years, importance of lncRNAs BC has been acknowledged. SLCO4A1-AS1 an oncogene colorectal cancer. However, role remains unknown. Materials and methods: The expression levels tissues were analyzed by qRT-PCR. effects knockdown on proliferation determined CCK8 assay. Transwell assay was used to evaluate migration invasion. Furthermore, xenograft utilized test effect growth vivo. Results:...
Abstract Background Multidrug‐resistant ( MDR ) gram‐negative bacilli pose a serious and rapidly emerging threat to recipients of solid organ transplants SOT s). However, extended‐spectrum β‐lactamases ESBL s), as one the cardinal mechanisms resistance antimicrobial agents in recipients, remain obscure. The aim this study was investigate prevalence strains producing s patients with infections identify genes carried by them. Materials methods Isolates from various clinical specimens were...
Abstract The hepatic growth factor hepatopoietin Cn ( HPPCn ) prevents liver injury induced by carbon tetrachloride in rats. Sphingosine 1‐phosphate S1P is a bioactive sphingolipid produced sphingosine kinase SphK ). and receptors S1PRs are involved fibrogenesis oxidative injury. This work sought to understand the mechanism which / protective effects of on ethanol‐induced fibrosis. Transgenic mice with liver‐specific overexpression +/+ were generated. Two ethanol feeding protocols used...
Renal cell carcinoma (RCC) is one of the third most common types urological cancer worldwide. Long non‑coding RNA (lncRNA) ROR has been reported to be important in regulating malignant activities different cancer, however, function lncRNA RCC remains fully elucidated. In order investigate RCC, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis was used detect expression renal tissues and adjacent tissues. Cell proliferation apoptosis were determined using...
Hepatic hemangioma patients with Kasabach-Merritt syndrome have reportedly been cured by liver transplantation. However, transplantation as a potential cure for stable patient without remains debatable. We report the case of 27-year-old female giant hepatic hemangioma. The measured 50 × 40 25 cm in size and weighed 15 kg, which is largest heaviest reported literature. showed jaundice, ascites, anemia, appetite loss; but no disseminated intravascular coagulation was observed through...
Background:To explore a better balance between efficacy and complications, we respectively compared the clinical outcome of low-dose high-dose rATG induction therapy with control group in renal transplantations from March 2009 to 2012. Material andMethods:281 kidney transplant recipients were included 3 groups. The (n=39) received 1 mg/kg on first day 0.5 next consecutive days post-transplantation. (n=30) for 6 days. (n=212) no therapy. All patients treated Prednisolone, Mycophenolate...
The function of lncRNA CRNDE and its role in prostate cancer (PC) remains unclear. aim this study was to determine the expression level PC tissues elucidate PC. levels were measured by quantitative reverse transcription polymerase chain reaction. cells studied using loss-of-function assays vitro. Cell proliferation, migration, invasion, apoptosis assessed via Counting Kit-8, colony formation, flow cytometry, wound healing, transwell chamber assays. A luciferase reporter assay used...
The aim of this study was to evaluate the effect lycopene on hypoxia-induced testicular injury in rat model and explore underlying mechanism.Six-week-old male Wistar rats (n = 36) were randomly divided into three groups 12/group): a normal group (NG, sham control), varicocele (VG), treated by (VLG). Bilateral renal veins constriction performed VG VLG. Simultaneously, VLG intragastric administration. Four weeks later, sperm collected for analysis. Testes epididymides harvested morphological...
Background Kidneys obtained from deceased donors increase the incidence of delayed graft function (DGF) after renal transplantation. Here we investigated influence risk factors with DGF, and developed a donor scoring system for DGF prediction.Methods This retrospective study was conducted in 1807 kidney 3599 recipients who received kidneys via transplants 29 centers China. We quantified associations clinical characteristics. A validated using an independent sample set.Results The 19.0%. Six...
Prostate cancer (PC) is the second leading cause of cancer-related death among men worldwide. Downregulation miR-485-3p has been revealed to participate in tumorigenesis and progression many types cancer. However, clinical biological role PC remains largely unknown.The expression was analyzed published databases detected our samples cell lines by RT-qPCR assay. CCK8, transwell invasion migration, colony formation assays were performed investigate function miR-485-3p. Bioinformatical...
BACKGROUND:The number and survival rate of simultaneous liver-kidney transplant (SLKT) recipients have increased dramatically since 2002. However, the long-term effectiveness SLKT in patients with hepatitis B is unknown. MATERIAL AND METHODS:Forty-six who visited Organ Transplant Center Shanghai First People’s Hospital between January 2001 May 2005 had virus infection renal failure (any degree), underwent organ transplantation: 21 25 liver (LT) alone. RESULTS:The 1-, 3-, 5-year rates were...
Abstract An adenocarcinoma of the appendix invading urinary bladder, which is difficult to be diagnosed before operation, an extremely rare disease. Only a few cases have been reported. Here we reported case patient with mucinous bladder. The in this study was 54-years old man who admitted due 6-month history intermittent episodes irritative voiding symptoms and weight loss. did not any gastrointestinal symptoms. physical examination, laboratory cytology urine, computed tomography cystoscopy...
<title>Abstract</title> Background The features of resistance to mitophagy contribute significantly invasion, malignancy and cell survival. But the mechanism in clear renal carcinoma (ccRCC) remains unclear It is valuable estimate molecular characters as a clinical factor for prognosis immune phenotypes ccRCC. Methods Clinical data ccRCC patients, including genome transcriptome data, were downloaded from Cancer Gene Atlas (TCGA) International Genome Consortium (ICGC) database. differentially...