A5100381975- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- Signaling Pathways in Disease
- Osteoarthritis Treatment and Mechanisms
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Nuts composition and effects
- Topic Modeling
- Protease and Inhibitor Mechanisms
- Cancer Genomics and Diagnostics
- Advanced Glycation End Products research
- Cancer-related gene regulation
- Silkworms and Sericulture Research
- Vagus Nerve Stimulation Research
- Gastric Cancer Management and Outcomes
- Bariatric Surgery and Outcomes
- Autophagy in Disease and Therapy
- Diabetes Treatment and Management
Affiliated Hospital of Southwest Medical University
2021-2025
Second Affiliated Hospital of Jilin University
2024
University of South China
2020-2024
Zhejiang University of Science and Technology
2024
Shandong Provincial Hospital
2023
Shandong First Medical University
2023
Binzhou People's Hospital
2023
Nankai University
2023
Taizhou Municipal Hospital
2020-2022
Shanghai University of Traditional Chinese Medicine
2022
To investigate the expression level of TUG1 and one its transcript variants (n377360) in osteosarcoma cells assess role proliferation apoptosis U2OS cell line.TUG1 n377360 levels patients with osteosarcomas human line were evaluated using real-time quantitative PCR. transected siRNA or non-targeting siRNA. MTS was performed to flow cytometry applied analyze apoptosis.We found significantly higher tissues compared matched non-tumorous tissues. In this, suppression by impaired potential cells....
Exosomal long non-coding RNAs (lncRNAs) serve as excellent candidate biomarkers for clinical applications. The expression of differentiation antagonizing non-protein coding RNA (DANCR) has been shown to be decreased in breast cancer (BC) tissues and cell lines. However, the value circulating exosomal DANCR BC not explored.A total 120 patients, 70 benign disease (BBD) 105 healthy women were recruited this study. Total was extracted from serum samples, level lncRNA evaluated by quantitative...
Non-small cell lung cancer (NSCLC) is the most common type of cancer. Currently, treatment methods generally cause poor prognosis. Therefore, in order to seek new options, we explored internal mechanism NSCLC. Firstly, SOX2-OT/miR-30d-5p/PDK1 axis regulated by lncRNA SOX2-OT was predicted bioinformatics methods, and expression SOX2-OT, miR-30d-5p, PDK1 mRNA cells were detected qRT-PCR while protein western blot. The results expressed that NSCLC, notably overexpressed miR-30d-5p markedly...
Iron overload and ferroptosis are associated with intervertebral disc degeneration (IDD); however, the mechanism underlying regulation of iron homeostasis remains to be elucidated. Nuclear factor erythroid 2‑related 2 (Nrf2) has been reported regulate cellular homeostasis; its impact on IDD pathology action requires further investigation. In present study, immunohistochemistry analysis Nrf2 expression in cartilage endplate (CEP) was conducted it demonstrated that increased CEP at early...
There is a male preponderance in gastric cancer (GC), which suggests role of androgen and receptor (AR). However, the mechanism AR signaling GC especially female patients remains obscure. We sought to identify pathway that might be related prognosis examine potential clinical utility antagonist for treatment. Deep learning gene set enrichment analysis was used critical factors associated with gender bias (n = 1390). Gene expression profile performed screen differentially expressed genes...
Abstract Objectives This study investigated the potential therapeutic benefits of PNU120596, a positive allosteric modulator α7 nicotinic acetylcholine receptor (α7nAChR), in mitigating acute lung injury (ALI) induced by lipopolysaccharide (LPS) mouse model. Specifically, we sought to examine impact PNU120596 on PI3K/AKT signaling pathway context ALI. Methods ALI was mice LPS administration, and protective effects were assessed. Lung injury, function, inflammatory response evaluated....
Introduction: Human ovaries begin development in utero. Through oogenesis, the numbers of oocytes and primordial follicles peak to a few million during fetal development, then decline hundreds thousands per ovary at birth. These do not regenerate are thus regarded as ovarian reserve. Over life course, reserve continues deplete, due atresia activation, until menopause when about 1000 remain. Exposure chemotherapy drugs environmental pollutants can accelerate follicular depletion potentially...
Colorectal cancer (CRC) is characterized by aggressive tumor growth and chemoresistance, with Enhancer of zeste homolog 2 (EZH2) serving a pivotal role in these processes. However, the mechanisms which it drives proliferation therapeutic resistance through autophagy regulation remain unclear. Here, we demonstrated that EZH2 expression elevated CRC tissues cell lines, correlating chemoresistance diagnostic potential (Area Under Curve, AUC = 0.968). knockdown markedly reduced proliferation,...
Abstract Under long‐term artificial selection, the domestic silkworm ( Bombyx mori ) has increased its silk yield tremendously in comparison with wild progenitor, mandarina . However, molecular mechanism of increase is still unknown. Comparative analysis long non‐coding RNAs (lncRNAs) may provide some insights into understanding this phenotypic variation. In study, using RNA sequencing technology data gland and silkworms, we identified 599 lncRNAs silkworm. Compared protein‐coding genes,...
Abstract Background The purpose of this study was to explore the regulatory mechanism long non-coding RNA (lncRNA) LINC00461 underlying breast cancer invasion and migration via miR-144-3p/KPNA2 axis. Methods Bioinformatics methods were applied screen differentially expressed mRNAs, miRNAs lncRNAs for construction a competing endogenous (ceRNA) network. LINC00461, KPNA2 miR-144-3p identified, predicted be target significantly correlated with prognosis. To make findings more convincible, we...
Lung adenocarcinoma (LUAD) is a common type of malignancy lung cancers. Long intergenic noncoding RNAs (lincRNAs) have emerged as crucial regulators various cancers, including LUAD. LINC01006 newly discovered long RNA (lncRNA) whose function in LUAD remains to be explored. This study explore the role Quantitative real-time PCR (RT-qPCR) analysis and Western blotting were used determine expression levels protein levels, respectively. Functional assays animal experiments investigated both vivo...
Accumulating evidences indicate that cancer-related lncRNAs occur frequent somatic copy number alternation (SCNA). Although individual SCNA have been implicated in tumor biology, their regulatory mechanism has not assessed a systematic way. In order to explore the expression characteristics and biological functions of cancer, we built computational framework based on lncRNA profiles, numbers dosage sensitivity score (DSS). First, found with different DSS were involved distinct processes,...
Renal cell carcinoma (RCC) is one of the third most common types urological cancer worldwide. Long non‑coding RNA (lncRNA) ROR has been reported to be important in regulating malignant activities different cancer, however, function lncRNA RCC remains fully elucidated. In order investigate RCC, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis was used detect expression renal tissues and adjacent tissues. Cell proliferation apoptosis were determined using...
Objective: Our previous study showed that Coiled-Coil Domain Containing 80 (CCDC80) accelerates the development of atherosclerosis by decreasing lipoprotein lipase (LPL) expression and activity in apoE knockout mice. However, regulatory mechanism for CCDC80 is unclear. This was designed to evaluate whether noncoding RNAs involved regulation vascular smooth muscle cells. Methods Results: Bioinformatics prediction luciferase reporter gene results miR-141-3p/200a-3p bound 3′UTR CCDC80....
Purpose: The purpose is to confirm whether long noncoding RNA HOXA-AS2 relieves chronic intermittent hypoxia (CIH)-induced lung inflammation. Methods: Male Sprague Dawley rats were used establisha CIH rat model. Hematoxylin and Eosin staining was on the tissue injury determine successful construction of animal Arterial partial pressure oxygen (PaO2) carbon dioxide (PaCO2) measured. overexpressed evaluate its role in progression development CIH. T cell differentiation cytokine production...
Increasing evidence has supported the prognostic and therapeutic values of long non-coding RNAs (LncRNAs) in human tumorigenesis. Hepatocellular carcinoma (HCC), as one most refractory diseases, continues to warrant investigation for novel clues enable early diagnosis. In present study, role LncRNA AB019562 cell proliferation metastasis was investigated HCC. Reverse transcription‑quantitative polymerase chain reaction analysis performed determine expression clinical HCC samples cultured...
Chronic myelocytic leukemia (CML) is characterized by increased and unregulated growth of predominantly myeloid cells in the bone marrow, accumulation these blood. We investigated effects an anti-malarial drug, dihydroartemisinin (DHA), on K562 CML cells. identified 34 mRNAs eight lncRNAs dysregulated following DHA treatment pure hemin-induced Up- or downregulation potential targets with increasing concentration. also constructed analyzed a DHA-related mRNA-lncRNA regulation network cells,...
Colorectal cancer (CRC) is one of the most common diagnosed cancers around world. The poor prognosis and high fatality caused by metastasis are still challenges for clinical treatment. Therefore, it promising to clarify detailed molecular mechanism CRC metastasis. Accumulating evidences indicate that long noncoding RNAs (lncRNAs) play important roles in progression including CRC. In this study, function lncRNA UCA1 was investigated. confirmed be highly expressed colorectal cancer. Moreover,...
Long non-coding RNA (lncRNA) can predict the prognosis of patients with various cancers. The relationship between lncRNA taurine upregulated gene 1 (TUG1) and gastric carcinoma still needs to be further explored. Therefore, this study attempted explore TUG1 suffering from carcinoma.The database was retrieved China National Knowledge Infrastructure (CNKI), Chinese Biomedical literature Database (CBM), Scientific Journal (VIP), Wan Fang database, PubMed, EMBASE. Hazard ratios (HRs) its 95%...