A5100642000- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Angiogenesis and VEGF in Cancer
- CAR-T cell therapy research
- ATP Synthase and ATPases Research
- Glycosylation and Glycoproteins Research
- interferon and immune responses
- Pluripotent Stem Cells Research
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Urinary Tract Infections Management
- Cell death mechanisms and regulation
- Medicinal Plant Pharmacodynamics Research
- NF-κB Signaling Pathways
- Inflammatory mediators and NSAID effects
Shanxi Medical University
2018-2025
Nantong University
2014-2024
Nantong Tumor Hospital
2008-2024
CS Diagnostics
2023
Yangzhou University
2020-2021
Macau University of Science and Technology
2021
Beijing Children’s Hospital
2019
Capital Medical University
2019
Hebei Medical University
2018
Fourth Hospital of Hebei Medical University
2018
Endoplasmic reticulum (ER) stress-related genes are closely related to the occurrence, development, and immunotherapy response of tumors. This study provides a comprehensive assessment HSPA5 from pan-cancer perspective using multi-omics data. We analyzed function in multiple tumor types databases. Finally, immunohistochemistry was used examine relationship between expression tissue microarrays 100 patients with bladder cancer prognosis cancer. Using TCGA database, we were able determine that...
To investigate the expression level of TUG1 and one its transcript variants (n377360) in osteosarcoma cells assess role proliferation apoptosis U2OS cell line.TUG1 n377360 levels patients with osteosarcomas human line were evaluated using real-time quantitative PCR. transected siRNA or non-targeting siRNA. MTS was performed to flow cytometry applied analyze apoptosis.We found significantly higher tissues compared matched non-tumorous tissues. In this, suppression by impaired potential cells....
Patients with advanced bladder cancer gradually become less sensitive to chemotherapeutic agents, leading tumor recurrence. Initiating the senescence program in solid tumors may be an important means of improving short-term drug sensitivity. The role c-Myc cell was determined using bioinformatics methods. response cisplatin chemotherapy sample analyzed according Genomics Drug Sensitivity Cancer database. Cell Counting Kit-8 assay, clone formation and senescence-associated β-galactosidase...
MicroRNAs (miRNAs) are endogenous small non-coding RNAs that repress their targets at post transcriptional level. Existing studies have shown miRNAs important regulatory genes in hepatocellular carcinoma (HCC), as either tumor suppressors or oncogenes. MiR-122 is normally downregulated HCC and regarded a suppressor. Recently miR-122 has been reported to be regulated by CEBPA, which then involved novel pathway influence proliferation of cells. However it unknown whether CEBPA HCC. In this...
Abstract Vasculogenic mimicry (VM) is a new blood supply style in tumors and has long been treated as useful factor malignant tumor metastasis prognosis. Notch4 (a marker of Notch signaling pathway receptors), DLL4 ligands) KAI1/CD82 suppressor gene metastasis) are all effective predictive factors for metastasis. In this study, we analyzed correlations among VM, Notch4, DLL4, non-small cell lung cancer (NSCLC), their respective associations with patients’ clinicopathological parameters...
In order to clarify the effects of drought stress training on quality and resistance Codonopsis pilosula, this study used PEG simulate employed potting with water control for C. pilosula plants. The polysaccharide content, secondary metabolites, antioxidant system, photosynthetic pigment system after were analyzed. results showed that content fructans in root increased two rounds treatment, it was significantly higher than group. accumulation an upward trend during rehydration treatment....
Induced pluripotent stem cells (iPSCs) are a promising source of mesenchymal (MSCs) for clinical applications. In this study, we transformed human iPSCs using non-viral vector carrying the IL24 transgene pHrn-IL24. PCR and southern blotting confirmed integration into rDNA loci in four 68 iPSC clones. We then differentiated high expressing IL24-iPSC clone MSCs (IL24-iMSCs) that showed higher expression culture supernatants cell lysates than control iMSCs. IL24-iMSCs efficiently osteoblasts,...
Lung adenocarcinoma (LUAD) is the leading cause of cancer‑related mortality worldwide. Long non‑coding RNA (lncRNA) NUT family member 2A antisense 1 (NUTM2A‑AS1) dysregulated in LUAD; however, its role this disease remains unclear. The present study aimed to identify underlying molecular mechanism effect lncRNA NUTM2A‑AS1 LUAD by exploring whether could affect cell proliferation and apoptosis through microRNA (miR)‑590‑5p/methyltransferase 3, N6‑adenosine‑methyltransferase complex catalytic...
The aims of this study are to analyze the association microRNA-141 (miR-141) with clinicopathological parameters bladder cancer and evaluate value miR-141 in predicting prognosis cancer. In study, 114 patients were enrolled tissue specimens obtained from tumor zone adjacent normal area. expression was determined using SYRB Green quantitative real-time polymerase chain reaction assay further correlated patients' follow-up data. results indicated that upregulated malignant compared ones (P <...
ABSTRACT The anthrax protective antigen (PA) is the central component of three-part toxin, and it primary immunogenic in approved AVA vaccine “next-generation” recombinant PA (rPA) vaccines. Animal models have indicated that PA-specific antibodies (AB) are sufficient to protect against infection with Bacillus anthracis . In this study, we investigated domain specificity, affinity, mechanisms neutralization, synergistic effects from a single donor following vaccination rPA vaccine....
Background Independent factors are needed to supplement vesical imaging‐reporting and data system (VI‐RADS) improve its ability identify muscle invasive bladder cancer (MIBC). Purpose To assess the correlation between MIBC diffusion kurtosis imaging (DKI) ratio, VI‐RADS, other (such as tumor location). Study Type Retrospective. Population Sixty‐eight patients (50 males 18 females; age: 70.1 ± 9.5 years) with urothelial carcinoma. Field Strength/Sequence 1.5 T, conventional diffusion‐weighted...
Abstract Background Previous studies have demonstrated that the glycolytic enzyme phosphoglycerate kinase 1 (PGK1) can promote tumor development. This study sought to investigate specific role of PGK1 in bladder cancer (BLCA). Methods Public databases and immunohistochemistry assays were utilized analyze expression BLCA its prognostic significance. Cell proliferation was assessed through CCK‐8 colony formation assays, while level metastasis evaluated using transwell migration experiments....
Summary The incidence of renal cell carcinoma is increasing all over the world. molecular mechanisms for tumorigenesis, progression and prognosis are still unknown. erythropoietin‐producing hepatoma amplified sequence (Eph) receptors have been reported to be expressed aberrantly in many types human cancers particular EphA5 may play a role certain cancers. In this study, set clear (cc RCC ) tissues were subjected immunohistochemistry. relationship between protein expression...
At present, in vitro cell experiments have confirmed that RaddeaninA can effectively inhibit the proliferation of some tumor cells, but effect on lung cancer cells has not been observed. Therefore, this study explored its and mechanism action. Human lines were treated with serum-free medium varied concentrations Raddeanin A. Cell apoptosis determined using MTT, flow cytometric assays, respectively. The intracellular level ROS was DCFH-DA assay. Protein mRNA expressions bax, bcl-2 cyt c...
GAPDH(glyceraldehyde-3-phosphate dehydrogenase) gene is a key enzyme in carbohydrate metabolism and always used as reference gene. To clarify complete the biosynthetic pathway of polysaccharide, GAPDH Codonopsis pilosula, named CpGAPDH, was cloned according to transcriptome using potato query. The CpGAPDH contained 1 014 bp open reading frame(ORF) encoded protein with 337 amino acids. Bioinformatic analysis clearly suggested that shared high similarity among other plants, had closest...
GDP-mannose is an important precursor for the synthesis of Codonopsis pilosula polysaccharides and involved in sugar chains. Phosphomannomutase(PMM)catalyzes conversion mannose-6-phosphate(Man-6-P)to mannose-1-phosphate(Man-1-P)to synthesize GDP-mannose. In this study, specific primers were designed based on PMM gene sequence information transcriptome data, full length C. was cloned named CpPMM. The correlation between CpPMM expression polysaccharide analyzed by a series bioinformatics...