A5088340227- Immune cells in cancer
- Biochemical effects in animals
- Menstrual Health and Disorders
- Stress Responses and Cortisol
- Metabolomics and Mass Spectrometry Studies
- Ruminant Nutrition and Digestive Physiology
- Animal Nutrition and Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Pharmacological Effects of Natural Compounds
- Nanoplatforms for cancer theranostics
- Traditional Chinese Medicine Studies
- Cancer Immunotherapy and Biomarkers
- Fatty Acid Research and Health
- Ferroptosis and cancer prognosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Meat and Animal Product Quality
- Polysaccharides Composition and Applications
- Animal Genetics and Reproduction
- Inflammasome and immune disorders
- Advanced Chemical Sensor Technologies
- Cancer Mechanisms and Therapy
- Phagocytosis and Immune Regulation
- Intracranial Aneurysms: Treatment and Complications
- Selenium in Biological Systems
Shandong University of Traditional Chinese Medicine
2016-2025
Shanghai Artificial Intelligence Laboratory
2025
Beijing Academy of Artificial Intelligence
2025
Zhongda Hospital Southeast University
2025
Shanxi Agricultural University
2024
Shanghai Jiao Tong University
2024
Qingdao Agricultural University
2008-2022
Heilongjiang Academy of Agricultural Machinery Engineering
2021
Second Hospital of Tianjin Medical University
2006-2017
Tianjin Medical University
2006-2017
Glioblastoma multiforme (GBM) remains incurable despite aggressive implementation of multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a narrow margin around the initial resected lesion due to postsurgery residual glioma stem cells (GSCs). Tracking and eradicating GSCs is critical for preventing postoperative this devastating disease, yet effective strategies remain elusive. Here, we report cavity-injectable nanoporter-hydrogel superstructure that...
Sepsis, which is the most severe clinical manifestation of acute infection and has a mortality rate higher than that cancer, represents significant global public health burden. Persistent methicillin-resistant
Idiopathic pulmonary fibrosis (IPF), a lethal respiratory disease with few treatment options, occurs due to repetitive microinjuries alveolar epithelial cells (AECs) and progresses an overwhelming deposition of extracellular matrix (ECM), ultimately resulting in fibrotic scars destroyed the architecture. Here, inhaled ribosomal protein-based mRNA nanoformulation is reported for clearing intrapulmonary ECM re-epithelializing disrupted epithelium, thereby reversing established foci IPF. The...
Glioblastoma multiforme (GBM) is notoriously resistant to immunotherapy due its intricate immunosuppressive tumor microenvironment (TME). Dysregulated cholesterol metabolism implicated in the TME and promotes progression. Here, it found that levels GBM tissues are abnormally high, glioma-supportive macrophages (GSMs), an essential "cholesterol factory", demonstrate aberrantly hyperactive efflux, providing fuel growth induce CD8
Journal Article Metabolomics analysis reveals large effect of roughage types on rumen microbial metabolic profile in dairy cows Get access S. Zhao, Zhao State Key Laboratory Microbial Resources Institute Microbiology Chinese Academy Sciences Beijing ChinaState Animal Nutrition Agricultural China Search for other works by this author on: Oxford Academic Google Scholar J. ChinaCollege Science and Technology Inner Mongolia University the Nationalities Tongliao D. Bu, Bu P. Sun, Sun Wang, Wang...
Deep Candida albicans infection is one of the major causes death in immunosuppressed hosts. Remodeling macrophages to phenotype M1 can decrease fungus burden and facilitate combating C. under an immunosuppressive state. In this study, a nanotrinity was exploited direct fungicidal macrophage polarization by leveraging regulation pathways redifferentiation. Conventional chemotherapeutic imatinib, which abrogate M2 via "shutting off" STAT6 phosphorylation pathway, encapsulated biodegradable...
The stemness loss-associated dysregeneration of impaired alveolar type 2 epithelial (AT2) cells abolishes the reversible therapy idiopathic pulmonary fibrosis (IPF). We here report an inhalable mucus-penetrating lipid nanoparticle (LNP) for codelivering dual mRNAs, promoting realveolarization via restoring AT2 IPF treatment. Inhalable LNPs were first formulated with dipalmitoylphosphatidylcholine and our in-house-made ionizable lipids high-efficiency mucus penetration codelivery messenger...
Immune checkpoint blockade (ICB) has emerged as one of the breakthrough approaches for tumor immunotherapy. However, known an immune "cold" tumor, breast cancer harbors immunosuppressive niche that compromises ICB-based therapy. Chemoimmunotherapy combines a chemotherapeutic with immune-modulating agent, representing promising tactic to combat cancers, while lack effectively targeted co-delivery strategy is main obstacles achieve synergistic utilization. Herein, self-assembled PEGylated pure...
Natural products have antitumor, anti‐inflammatory, antioxidant, and other pharmacological activities are an important source of drugs for prevention treatment various diseases. However, the inherent defects natural in physiological media such as poor solubility stability short biological half‐life limit their clinical application. In recent years, more attention has been paid to science drug delivery by nanoscale materials. A large number vitro vivo studies further confirmed efficacy safety...
Objective. We discuss the influence of anger emotional stress upon VEGF/VEGFR2 and its induced PI3K/AKT/mTOR signal pathway. Methods. created a rat model (anger-out anger-in) response using social isolation resident-intruder paradigms assessed changes in hippocampus’ VEGF content, neuroplasticity, signaling Results. The method successfully generated anger-out anger-in models that differed significantly composite aggression score, incubation, open field behavior, sucrose preference, weight...
The ATP6V0A4 gene encodes the a4 subunit of Vacuolar H+-ATPase (V-ATPase), which mediates hydrogen ion transport across membrane. Previous studies have suggested that mutations in consistently result a loss function (LOF), impairing efficacy V-ATPase and leading to distal renal tubular acidosis (dRTA) sensorineural hearing loss. Here, we identified 32-year-old male patient his father, both whom harbored heterozygous p.V512L mutation, exhibited with hypochloremic metabolic alkalosis, acidic...
Metal ions are widely adopted to potentiate oxidative damage-induced immunogenic cell death (ICD) and regulate immune pathways. However, current ion delivery platforms lack precise administration over distribution retention time within the tumor microenvironment, leading high systemic toxicity suboptimal therapeutic efficacy. Here, local electrochemical immunotherapy is developed by implanting a microenvironment–activated Zn//MnO 2 battery, which uses body fluid as an electrolyte endogenous...
Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide. We validated the utility plasma metabolomics analysis in clinical diagnosis acute TBI rat model controlled cortical impact (CCI) using gas chromatography/mass spectrometry (GC/MS). Thirty Sprague-Dawley rats were randomly divided into two groups 15 each: CCI group sham group. Blood samples obtained from within first 24 h after injury. GC/MS measurements performed to evaluate profile TBI-induced metabolic...
Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS), common mental health disturbance associated with several periodic psychological symptoms in women. Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PMS/PMDD patients; however, side effects inevitable, especially long-term treatment. In previous studies, natural compound paeonol Moutan Cortex was found to play effective roles central nervous system disorders its...
Rationale: Vascular abnormality stemming from the hypoxia-driven elevation of proangiogenic factors is a hallmark for many solid malignant tumors, including colorectal cancer (CRC) and its liver metastasis. We report hypoxia-triggered liposome-supported metal-polyphenol-gene bio-nanoreactor to tune factor-mediated immunotolerance synergize elicited tumoricidal immunity CRC treatment. Methods: With aid polyphenol gallic acid, Cu2+ ion-based intracellular was synthesized delivery small...