A5103064292- Genetic Mapping and Diversity in Plants and Animals
- Seed and Plant Biochemistry
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Plant Molecular Biology Research
- Atomic and Subatomic Physics Research
- Peptidase Inhibition and Analysis
- Studies on Chitinases and Chitosanases
- Pancreatic function and diabetes
- Neurological Disorders and Treatments
- Ubiquitin and proteasome pathways
- Plant Reproductive Biology
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Childhood Cancer Survivors' Quality of Life
- Genetics and Plant Breeding
- FOXO transcription factor regulation
- Medical Imaging Techniques and Applications
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Congenital gastrointestinal and neural anomalies
- Cancer, Hypoxia, and Metabolism
- GABA and Rice Research
- Hepatocellular Carcinoma Treatment and Prognosis
Agricultural Genomics Institute at Shenzhen
2021-2024
Chinese Academy of Agricultural Sciences
2021-2024
Ministry of Agriculture and Rural Affairs
2021-2024
Texas Tech University
2024
Alibaba Group (China)
2023
University of Minnesota
2023
Chinese Academy of Sciences
2020-2022
Center for Excellence in Molecular Plant Sciences
2020-2022
University of Chinese Academy of Sciences
2022
Hebei Medical University
2021
Abstract Background Gestational diabetes mellitus (GDM) is a temporary form of during pregnancy, which influences the health maternal-child in clinical practice. It still urgent to develop new effective treatment for GDM. Naringenin bioactive ingredient with multiple activities including anti-diabetic. In current study, effects naringenin on GDM symptoms, insulin tolerance, inflammation, and productive outcomes were evaluated underlying mechanisms explored. Methods We administrated mice...
Intercellular communication in adjacent cell layers determines fate and polarity, thus orchestrating tissue specification differentiation. Here we use the maize stomatal apparatus as a model to investigate determination. Mutations ZmBZU2 (bizui2, bzu2) confer complete absence of subsidiary cells (SCs) normal guard (GCs), leading failure formation mature complexes. Nuclear polarization actin accumulation at interface between mother (SMCs) (GMCs), an essential pre-requisite for asymmetric...
The transcription factor FoxN1 is essential for differentiation of thymic epithelial cell (TEC) progenitors during organogenesis. However, limited information available on the postnatal contribution to maintenance. To address this question, we generated a loxP-floxed (fx) mouse with three different promoter-driven inducible CreER(T) transgenes. Postnatal ubiquitous deletion caused dramatic atrophy in 5 days and more severe deterioration medullary TECs (mTECs) than cortical (cTECs). Induction...
Age-related thymic involution may be triggered by gene expression changes in lymphohematopoietic and/or nonhematopoietic epithelial cells (TECs). The role of cell-autonomous FoxN1 involved the process, but it is still a puzzle because shortage evidence from gradual loss-of-function and exogenous gain-of-function studies. Using our recently generated loxP-floxed-FoxN1(fx) mouse carrying ubiquitous CreER(T) (uCreER(T)) transgene with low dose spontaneous activation, which causes deletion age,...
Summary In Arabidopsis, the plasma membrane transporter PUT3 is important to maintain cellular homeostasis of polyamines and plays a role in stabilizing mRNAs some heat‐inducible genes. The Na + /H SOS1 protein kinase SOS2 are two salt‐tolerance determinants crucial for maintaining intracellular K homeostasis. Here, we report that genetically physically interacts with SOS2, these interactions modulate transport activity. Overexpression ( PUT3OE ) results hypersensitivity transgenic plants...
Abstract Lysine acetylation (Kac) as an important posttranslational modification of histones is essential for the regulation gene expression in hepatocellular carcinoma (HCC). However, atlas whole acetylated proteins HCC tissues and difference protein between normal human are unknown. In this report, we characterized proteome acetyl (acetylome) profile normal, paracancerous, liver clinical samples by quantitative proteomics techniques. We identified 6781 sites 2582 quantified 2492 1190...
To determine the biochemical characteristics of lung cancer tissue using in vitro (1)H-MRS, and investigate correlation between survival probabilities lactate (Lac), creatine (Cr), choline (Cho) concentrations measured by (1)H-MRS.A total 21 patients with were included this retrospective study. (1)H-MRS spectra measurements performed at 6.35T a JNM-EX270, high-resolution FT-NMR spectrometer.When normal was compared tissue, significant differences noted most consistently levels Lac Cho,...
Emerging studies have demonstrated that microRNAs (miRNAs) play crucial roles in carcinogenesis of many developing human tumours. However, the functions and mechanisms miR-297 lung cancer have, up to now, been largely undefined.Here, expression was measured adenocarcinoma tissues cell lines, using qRT-PCR. Lung line treated with an mimic. MTT colony analysis were performed detect proliferation formation. The direct target gene assessed by qRT-PCR, Western blotting luciferase assays.We...
Plasticity in root system architecture (RSA) allows plants to adapt changing nutritional status the soil. Phosphorus availability is a major determinant of crop yield, and RSA remodeling critical increasing efficiency phosphorus acquisition. Although substantial progress has been made understanding signaling mechanism driving phosphate starvation responses plants, whether how epigenetic regulatory mechanisms contribute poorly understood. Here, we report that Switch defective/sucrose...
Heterosis is a common phenomenon in plants and has been extensively applied crop breeding. However, the superior traits hybrids can only be maintained first generation but segregate following generations. Maintaining heterosis generations challenging highly desirable Recent study showed that maternally produced diploid seeds could achieved rice by knocking out three meiosis related genes, namely REC8, PAIR1, OSD1 to create MiMe combination with egg cell specific expression of BBM...
Aging increases susceptibility to infection, in part because thymic involution culminates reduced naïve T-lymphocyte output. Thymic epithelial cells (TECs) are critical ensure normal maturation of thymocytes and production peripheral T cells. The forkhead-class transcription factor, encoded by FoxN1, regulates development, differentiation, function TECs, both the prenatal postnatal thymus. We recently showed that expression keratin 14 (K14)-expressing is essential for maintenance medullary...
Hyperalgesia and allodynia are commonly observed in patients with diabetic neuropathy. The mechanisms responsible for neuropathic pain not well understood. Thus, this study, we examined the role played by purinergic P2X3 receptors of midbrain periaqueductal gray (PAG) modulating diabetes-induced because brain region is an important component descending inhibitory system to control central transmission. Our results showed that mechanical withdrawal thresholds were significantly increased...
Lysine-ε-acetylation (Kac) is a post-translational modification (PTM) that critical for metabolic regulation and cell signaling in mammals. However, its prevalence importance plants remain to be determined. Employing high-resolution tandem mass spectrometry, we analyzed protein lysine acetylation five representative Arabidopsis organs with 2 ~ 3 biological replicates per organ. A total of 2887 Kac proteins 5929 sites were identified. This comprehensive catalog allows us analyze proteome-wide...
Mouse models of experimental anti-glomerular basement membrane (anti-GBM) nephritis provide an analytical tool for studying spontaneous lupus nephritis. The potential Positron Emission Tomography (PET) was evaluated using 2-deoxy-2-[18F]fluoro-d-glucose (FDG) as a probe to monitor the progression anti-GBM induced in mouse model. imaging results were compared conventional measures renal function and pathological changes. Serum urinary vascular cell adhesion molecule-1 (VCAM-1) levels used...
We present Dual3D, a novel text-to-3D generation framework that generates high-quality 3D assets from texts in only $1$ minute.The key component is dual-mode multi-view latent diffusion model. Given the noisy latents, 2D mode can efficiently denoise them with single denoising network, while generate tri-plane neural surface for consistent rendering-based denoising. Most modules both modes are tuned pre-trained text-to-image model to circumvent expensive cost of training scratch. To overcome...
As a result of energy consumption and human activities, large amount carbon dioxide emissions has led to global warming, which seriously affects the growth development plants. Vegetables are an indispensable part people's diet. In plant kingdom, variety vegetables highly sensitive climate change. For them, increase just few degrees above their optimum temperature threshold can in loss yield quality. Emerging strategies such as practice management breeding varieties response above-optimal...
The aim of the study was to explore influence α‑lipoic acid (α‑LA) on cytotoxicity advanced glycation end‑products (AGEs) against SH‑SY5Y cells. AGE‑bovine serum albumin (BSA) incubated in vitro using cells as a target model, and control group set. Cells were exposed AGE‑BSA, α‑LA selectively added Cell growth death determined by MTT assay, which measures cellular metabolic rate, lactate dehydrogenase (LDH) leakage rate axonal length. Immunocytochemistry employed detect expression β‑amyloid...