A5067341242- Bone Metabolism and Diseases
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Estrogen and related hormone effects
- Ion channel regulation and function
- Atherosclerosis and Cardiovascular Diseases
- Diet, Metabolism, and Disease
- Animal Genetics and Reproduction
- Liver Disease Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Birth, Development, and Health
- Aortic Thrombus and Embolism
- Natural Antidiabetic Agents Studies
- Lipid metabolism and disorders
- Pharmacogenetics and Drug Metabolism
- Ion Transport and Channel Regulation
- Bone health and osteoporosis research
- Bone and Dental Protein Studies
- Pregnancy-related medical research
- Effects and risks of endocrine disrupting chemicals
- Cardiac Structural Anomalies and Repair
- S100 Proteins and Annexins
- Retinal Imaging and Analysis
- Cardiovascular Function and Risk Factors
- Neuroscience and Neuropharmacology Research
Fudan University
2018-2024
Zhongshan Hospital
2018-2024
The University of Texas Medical Branch at Galveston
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2022-2024
Shanghai Jiao Tong University
2024
Jiangnan University
2024
Wuxi Fourth People's Hospital
2024
Renji Hospital
2024
Second Military Medical University
2015-2021
Shanghai Changzheng Hospital
2021
Abstract Osteoporosis, characterized by bone mass reduction and increased fractures, has become a global health problem that seriously affects the of people, especially postmenopausal women; however, current pathogenesis osteoporosis (PMOP) not been thoroughly elucidated to date. In this study, bilateral ovariectomy was performed establish an OVX mouse model osteoporosis. UPLC-Q-TOF-MS-based lipidomics in combination with metabolomics were used analyze femur tissue mice. We found 11 polar...
Background/Aims: Glucagon-like peptide-1 (GLP-1)-based drugs are being used to achieve better glucose control in patients with type 2 diabetes, and GLP-1 mimetics such as liraglutide have shown therapeutic potential preventing diabetes-related microvascular macrovascular complications well comorbidities neurodegenerative disorders. In the present study, we investigated effects of on primary rat cortical astrocytes treated advanced glycation end-products (AGEs). Methods: Gene protein...
Release of Ca(2+) from the sarcoplasmic reticulum (SR) drives contractile function cardiac myocytes. Luminal regulation SR release is fundamental not only in physiology but also physiopathology because abnormal luminal known to lead arrhythmias, catecholaminergic polymorphic ventricular tachycardia (CPVT), and/or sudden arrest, as inferred animal model studies. regulates ryanodine receptor (RyR)2-mediated through mechanisms localized inside SR; one these involves interacting with...
ABSTRACT The Runx2 transcription factor is critical for commitment to the osteoblast lineage. However, its role in committed osteoblasts and functions during postnatal skeletogenesis remain unclear. We established a Runx2-floxed line with insertion of loxP sites around exon 8 gene. protein lacking region encoded by imported into nucleus binds target DNA but exhibits diminished transcriptional activity. specifically deleted gene using 2.3-kb col1a-Cre transgenic mice. Surprisingly, homozygous...
Carvedilol is the current β-blocker of choice for suppressing ventricular tachyarrhythmia (VT). However, carvedilol's benefits are dose-limited, attributable to its potent β-blocking activity that can lead bradycardia and hypotension. The clinically used carvedilol a racemic mixture S-carvedilol non-β-blocking R-carvedilol. We recently reported novel analogues effective in arrhythmogenic Ca(2+) waves stress-induced VT without causing bradycardia. Thus, R-carvedilol enantiomer may also...
The present study was performed to investigate the roles of anterior intestine in postprandial glucose homeostasis omnivorous Genetically Improved Farmed Tilapia (GIFT). Sub-adult fish (about 173 g) were sampled at 0, 1, 3, 8 and 24 h post feeding (HPF) after 36 food deprivation, time course changes intestinal transport, glycolysis, glycogenesis gluconeogenesis transcription enzyme activity level, as well plasma contents, analyzed. Compared with 0 HPF (fasting for h), mRNA levels both...
Intrauterine growth restriction (IUGR) modifications to postnatal skeletal may increase adult fracture, especially in females who have greater risk of osteoporosis. Little is known about the effect IUGR on patterns endochondral ossification and bone development. Here for first time we reveal formation, mineralization, strength female rats during early life adulthood. Endochondral rate hypertrophic zone (HZ) cell length (HCL) at distal femur proximal tibia, primary center (POC) whole tibia...
Recent studies by Moneer and Taylor [(2002) Biochem. J. 362, 13–21] have proposed a reciprocal regulation of two Ca2+-entry pathways AVP ([Arg8]-vasopressin) in A7r5 vascular smooth-amuscle cells. Their model proposes that inhibits CCE (capacitative Ca2+ entry) predicts rebound after the removal AVP. In present study, we used whole-cell perforated patch-clamp techniques to measure ISOC (store-operated current) corresponding When 100 nM is present, it activates with no apparent on activated...
The persistence of an epidemic obesity, coronary heart disease and type 2 diabetes suggests that new nutritional strategies are needed if the is to be overcome. A promising approach suggested by this thematic review carbohydrate restriction. Under conditions restriction, fuel sources shift from glucose fatty acids ketones, that ad libitum–fed carbohydrate-restricted diets lead appetite reduction, weight loss, improvement in surrogate markers cardiovascular disease. Recent researches focus on...
Amoxicillin is a common pediatric drug. However, to the best of our knowledge, role amoxicillin in enamel hypomineralization has not yet been fully elucidated. The aim present study was assess effects on mineralization, morphology ameloblasts, as well expression kallikrein‑related peptidase 4 (KLK4), and tight junction proteins, claudin 1 (CLDN1), (CLDN4) occludin (OCLN), ameloblasts juvenile mice. A total 36 3‑day‑old Kunming mice were randomly divided into three groups. administered 0, 50...
China has a high prevalence rate of Metabolic-associated fatty liver disease (MAFLD), and there is currently limited understanding the levels exercise self-efficacy (ESE) among individuals with MAFLD. The objective was to explore potential ESE patterns in older adults A cross-sectional study conducted on 800 from five communities April 20, 2023 August 15, 2023. Latent profile analysis (LPA) k-means clustering were used determine optimal number groups. Using univariate multivariate logistic...
Abstract Background Recent studies have shown that PCSK6 is significantly associated with dyslipidemia, inflammatory reaction, cardiovascular diseases, atherosclerosis. However, the relationship between polymorphisms and large artery atherosclerosis stroke has not been reported. We performed this study to investigate whether polymorphism risk of (LAA) in Chinese population. Methods Our enrolled a total 432 cases 448 healthy controls, controls were genotyped at polymorphic sites rs1135911...
The collateral circulation near the cerebral artery occlusion can contribute to relief of symptoms and signs stroke. Genetic factors play a decisive role in difference circulation. Survivin, encoded by baculoviral inhibitor apoptosis (IAP) repeat-containing 5 gene (BIRC5), plays an important maintaining long-term endothelial integrity homeostasis as angiogenic factor treatment vascular diseases. We hypothesized that genetic variations BIRC5 may severity influencing This study aimed at...