A5102021033- Reproductive Biology and Fertility
- Quantum Information and Cryptography
- Traditional Chinese Medicine Studies
- Quantum Mechanics and Applications
- Neurological Disease Mechanisms and Treatments
- Wound Healing and Treatments
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolomics and Mass Spectrometry Studies
- CAR-T cell therapy research
- Skin Protection and Aging
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Gallbladder and Bile Duct Disorders
- COVID-19 Clinical Research Studies
- Nerve injury and regeneration
- Innovative Teaching Methods
- Tryptophan and brain disorders
- Acne and Rosacea Treatments and Effects
- Effects of Vibration on Health
- Simulation-Based Education in Healthcare
- Cerebrovascular and genetic disorders
- Bone and Dental Protein Studies
- Calpain Protease Function and Regulation
Inner Mongolia People's Hospital
2024-2025
Michigan State University
2017-2024
Beijing University of Technology
2023
Daqing Oilfield General Hospital
2019-2022
Xiamen University
2012-2022
Second Military Medical University
2009-2021
Shanghai Changzheng Hospital
2017-2021
Military University
2020
Bengbu Medical College
2020
University of Notre Dame
2017
The objective of the current study was to investigate expression pattern and clinicopathological significance TRIM24 in patients with non-small cell lung cancer (NSCLC). profile NSCLC tissues adjacent noncancerous detected by immunohistochemistry. found be overexpressed 81 113 (71.7%) human samples correlated p-TNM stage (p = 0.0006), poor differentiation 0.004), Ki67 index (p<0.0001), cyclin D1(p 0.0096) p-Rb 0.0318). In addition, depleting small interfering RNA inhibited growth invasion...
Suppressor of cytokine signaling (SOCS) 1 and 3 methylation have been associated with clinical features outcomes cancer patients. However, their roles in determining the treatment response to transarterial chemoembolization (TACE) patients hepatocellular carcinoma (HCC) remain unknown.We found that presence SOCS3 is significantly major HCC patients, including tumor stage, lymph node vascular invasion. Of note, we observed closely related TACE response. In prognosis analyses, a poorer...
The aim of this study was to investigate histopathologic prognostic factors in patients with intrahepatic cholangiocarcinoma (ICC) whose tumors were resected determine the optimal surgical strategies.One hundred and two ICC who underwent laparotomy from July 1998 December 2000 followed up successfully. Histopathologic variables selected for univariate multivariate analyses evaluate their influence on outcome.The 1-, 3-, 5-year survival rates after surgery 56.9%, 25.5%, 16.9%, respectively....
BACKGROUND: Currently, the most effective treatment for intrahepatic cholangiocarcinoma (ICC) is complete hepatic tumour excision. OBJECTIVE: To identify clinical parameters associated with survival duration ICC patients following hepatectomy, and to construct a mathematical model predicting duration. METHODS: Demographic data variables 102 diagnosed ICC, who underwent exploratory laparotomy at single centre from July 1998 December 2000 were followed an average of 24 months, collected in...
The objective of the current study was to investigate expression pattern and clinicopathological significance MTA3 in patients with non-small cell lung cancer (NSCLC). profile NSCLC tissues adjacent noncancerous detected by immunohistochemistry. overexpressed 62 108 (57.4%) human samples correlated p-TNM stage (p<0.0001), nodal metastasis (p = 0.0009) poor prognosis (p<0.05). In addition, depletion small interfering RNAs inhibited growth colony formation A549 H157 lines. Moreover, induced...
Tongue color is an important tongue diagnostic index for traditional Chinese medicine (TCM). Due to the individual experience of TCM experts as well ambiguous boundaries among categories, there often exist noisy labels in annotated samples. Deep neural networks trained with labeled samples have poor generalization capability because they easily overfit on labels. A novel framework named confident-learning-assisted knowledge distillation (CLA-KD) proposed classification In this framework,...
MicroRNA (miRNA) in urine has been considered as a potential biomarker for early stage diagnosis of multiple diseases like urinary system cancer, kidney injury, and diabetes because their many demonstrated advantages including long-term stability noninvasiveness. However, the traditional enrichment extraction processes miRNAs from are cumbersome tedious due to low concentration carriers miRNAs. Herein, we present novel method collect concentrations dilute solutions such cell culture medium....
Short‑term efficacy and safety of prednisone in herpes zoster the effect on IL‑6 IL‑10 were investigated. A total 125 patients (aged 40‑70 years) with acute infective who admitted to Daqing Oilfield General Hospital selected divided into 3 groups according different treatment methods: low‑dose (n=44), middle‑dose (n=42) high‑dose (n=39) groups. The therapeutic effect, visual analogue scale (VAS) pain score, relieving disappearing time, stopping incrustation decrustation incidence adverse...
Hyperglycemia plays a major role in the development of diabetic macrovascular complications, including atherosclerosis and restenosis, which are responsible for most disability mortality patients. Osteopontin (OPN) is an important factor involved atherogenesis, hyperglycemia enhances transcriptional activity FoxO1 closely association with insulin resistance diabetes. Here, we showed that plasma OPN levels were significantly elevated type 2 patients positively correlated glycated albumin...
Restrained adult male rats of the Sprague-Dawley strain were exposed for a 20-min duration to sublethal intensities heat, vibration, and combination heat vibration. The incidence mortality resulting from simultaneous exposure both environmental stresses was significantly greater than would be predicted if these act independently each other. Hematocrit, hemoglobin, serum glutamic-oxalacetic transaminase levels elevated immediately after Heat in with vibration increased values although stress...
Abstract Background No specific therapeutic agents or vaccines are available for the treatment of Coronavirus disease 2019 (Covid-19) yet. In this study, we aimed to assess efficacy high dose ulinastatin patients with Covid-19. Methods Twelve hospitalized confirmed SARS-CoV-2 infection were treated beyond standard care. The changes clinical manifestations, laboratory examinations and chest images retrospectively analyzed. Results A total 10 severe Covid-19 2 moderate received treatment....
To investigate the molecular mechanisms of laminar shear stress on inhibition apoptosis in endothelial cells, human umbilical vein cells (HUVECs) were starved medium containing 2% fetal bovine serum and 20 dyne/cm(2) stress.HUVECs subjected to or incubated a static condition then Smac/DIABLO expression was quantified by reverse-transcription polymerase chain reaction, real-time PCR, western blot. The effect migration proteins detected immunofluorescence microscopy.Results demonstrated that...
Abstract We designed a new type of polyadenylation-signal (PAS) trap vector system in living mice, the piggyBac (PB) (PAS-trapping (EGFP)) gene trapping vector, which takes advantage efficient transposition ability PB and insertional mutagenesis PAS-trapping. The reporter PB(PAS-trapping is an EGFP with its own promoter, but lacking poly(A) signal. Transgenic mouse lines carrying protamine 1 (Prm1) promoter-driven transposase transgenes (Prm1-PBase) were generated by microinjection. Male...
Abstract BACKGROUND Treatment of severe Corona Virus Disease 2019 (COVID-19) is challenging. We performed a phase 2 trial to assess the efficacy and safety human umbilical cord-mesenchymal stem cells (UC-MSCs) treat COVID-19 patients with lung damage, based on our 1 data. METHODS In this randomized, double-blind, placebo-controlled trial, we recruited 101 damage. They were randomly assigned receive either UC-MSCs (4 × 10 7 per infusion) or placebo day 0, 3, 6. The primary endpoint was an...
This study aimed to investigate the roles of COP9 signalosome subunit 8 (COPS8) and its underlying mechanism in cutaneous melanoma. Bioinformatics tools were utilized analyze expression COPS8 melanoma, while Kaplan-Meier analysis was employed assess correlation between patients' overall survival. The proliferation, migration, invasion cells estimated by CCK8, colony formation, Transwell assays. Western blot used check epithelial-mesenchymal transition (EMT)-related proteins. Results showed...