A5100750684- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Mass Spectrometry Techniques and Applications
- Advanced Sensor and Energy Harvesting Materials
- Conducting polymers and applications
- Plasmonic and Surface Plasmon Research
- Analytical Chemistry and Sensors
- Rock Mechanics and Modeling
- Parasitic Diseases Research and Treatment
- Advanced Biosensing Techniques and Applications
- Advanced Proteomics Techniques and Applications
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Optical Coatings and Gratings
- Drug Transport and Resistance Mechanisms
- Photonic and Optical Devices
- Biofuel production and bioconversion
- Photonic Crystals and Applications
- Metabolomics and Mass Spectrometry Studies
- Parasites and Host Interactions
- Neuroscience and Neural Engineering
- Cytokine Signaling Pathways and Interactions
- Microfluidic and Bio-sensing Technologies
- Gold and Silver Nanoparticles Synthesis and Applications
- Neurological Disease Mechanisms and Treatments
Shanghai Jiao Tong University
2016-2025
Shanghai East Hospital
2021-2025
Beijing University of Posts and Telecommunications
2012-2025
Wuyi University
2024
Tongji University
2019-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2002-2024
Beijing Forestry University
2022-2024
Hebei GEO University
2024
Tongji Hospital
2024
University of Science and Technology of China
2023-2024
Chimeric antigen receptor (CAR) T cell therapy has demonstrated proven efficacy in some hematologic cancers. We evaluated the safety and of LCAR-B38M, a dual epitope-binding CAR directed against 2 distinct B maturation epitopes, patients with relapsed/refractory (R/R) multiple myeloma (MM). This ongoing phase 1, single-arm, open-label, multicenter study enrolled (18 to 80 years) R/R MM. Lymphodepletion was performed using cyclophosphamide 300 mg/m2. LCAR-B38M cells (median CAR+ cells, 0.5 ×...
Abstract In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research clinical practice. However, metabolic analysis bio-samples needs tedious sample preparation, due to the complexity low molecular abundance. A further challenge is construct diagnostic tools. Herein, we developed a platform using silver nanoshells. We synthesized SiO 2 @Ag with tunable shell structures by multi-cycled mirror reactions....
A multifunctional PVA/cellulose hydrogel electrolyte prepared using a simple method is used in flexible supercapacitors.
Multiple plasmon-induced transparencies are numerically predicted in an ultracompact plasmonic structure, comprising series of stub resonators side-coupled with a metal-isolator-metal waveguide. Because the phase-coupled effect, electromagnetically induced transparency (EIT)-like spectral response occurs between two adjacent detuned resonant wavelengths. In this approach, multiple EIT-like responses, bandwidths order several nanometers, obtained structure small footprint about 0.6 μm2. An...
Current metabolic analysis is far from ideal to engage clinics and needs rationally designed materials device. Here we developed a novel plasmonic chip for clinical fingerprinting. We first constructed series of chips with gold nanoshells on the surface through controlled particle synthesis, dip-coating, sputtering mass production. integrated optimized microarrays laboratory automation micro-/nanoscaled experiments, which afforded direct high-performance fingerprinting by laser...
Abstract Cardiovascular diseases lead to 31.5% of deaths globally, and particularly myocardial infarction (MI) results in 7.4 million per year. Diagnosis MI monitoring for prognostic use are critical clinical management biomedical research, which require advanced tools with accuracy speed. Herein, we developed a plasmonic gold nano-island (pGold) chip assay diagnosis MI. On-chip microarray analysis serum biomarkers (e.g., cardiac troponin I) afforded up 130-fold enhancement near-infrared...
Detection of biomarkers in biosystems plays a key role advanced biodiagnostics for research and clinical use. Design new analytical platforms is challenging demand, addressing molecular capture subsequent quantitation. Herein, we developed label-free electrochemical sensor CD44 by ligand-protein interaction. We assembled carbon nanotube composites on the electrode to enhance electronic conductivity 6.2-fold reduce overpotential with shift 77 mV. conjugated hyaluronic acid (HA) surface...
Cancers heavily threaten human life; therefore, a high-accuracy diagnosis is vital to protect beings from the suffering of cancers. While biopsies and imaging methods are widely used as current technologies for cancer diagnosis, new detection platform by metabolic analysis expected due significant advantages fast, simple, cost-effectiveness with high body tolerance. However, signal molecule biomarkers too weak acquire diagnosis. Herein, precisely engineered metal-organic frameworks laser...
Tough, anti-drying, thermoplastic, and biodegradable hydrogels was developed successfully applied as a wide linear range fast response strain sensor.
Chitosan/poly(vinyl alcohol) hydrogels with high adhesion of up to 527 kPa due the synergy phytic acid and boric acid. The hydrogel-based strain sensor has sensitivity (gauge factor = 4.61) wide linear range (up 1000%).
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by dopaminergic neuron death in the substantia nigra, leading to motor dysfunction. Autophagy dysregulation has been implicated PD pathogenesis. This study explores role of miR-214-3p PD, focusing on its impact autophagy and viability. Using vitro vivo models, we demonstrate that inhibits promotes apoptosis. Behavioral assessments molecular analyses reveal exacerbation symptoms upon overexpression. Furthermore,...
Detection and inhibition of bacteria are universally required in clinics daily life for health care. Developing a dual-functional material is challenging demand, engaging advanced applications both defined bioanalysis targeted biotoxicity. Herein, magnetic silver nanoshells designed as multifunctional platform the detection bacteria. The optimized enable direct laser desorption/ionization mass spectrometry based metabolic analysis (≈10 µL-1 ), complex biofluids. serum infection process (0-10...
BackgroundMetabolic syndrome (MetS) is highly related to the excessive accumulation of visceral adipose tissue (VAT). Quantitative measurements VAT are commonly applied in clinical practice for measurement metabolic risks; however, it remains largely unknown whether texture can evaluate adiposity, stratify MetS and predict surgery-induced weight loss effects.Methods675 Chinese adult volunteers 63 obese patients (with bariatric surgery) were enrolled. Texture features extracted from VATs...
Hydrogel strain sensors with extreme temperature tolerance have recently gained great attention. However, the sensing ability of these hydrogel changes temperature, resulting in variety output signals that causes signal distortion. In this study, double-network hydrogels comprising SiO2 nanoparticles composed polyacrylamide and phytic acid-doped polypyrrole were prepared applied on a wide range, high adhesiveness, invariable sensitivity under flame cold environments. The had stable...
Conductive hydrogels crosslinked by charge-transfer complexes are prepared and fabricated as strain temperature sensors with high sensitivity. The hydrogel-based can retain good sensing performance after the thermoplastic process.
Abstract Efficient diagnosis of mycobacterial infections can effectively manage and prevent the transmission infectious diseases. Unfortunately, existing diagnostic strategies are challenged by long assay times, high costs, highly specialized expertise to distinguish between pulmonary tuberculosis (PTB) nontuberculous diseases (NTM‐PDs). Herein, in this study, an optimized 3D paper‐based analytical device (µPAD) is incorporated with a closed lateral flow (LF) strip into loop‐mediated...
Abstract Detection of circulating tumor cells (CTCs) in patient's blood is an important approach to cancer diagnosis and prognosis, but has been challenging due the rarity cells. Here, a magnetic‐enhanced capturing CTCs onto plasmonic gold (pGOLD) chip, through microfluidic immunomagnetic method, demonstrated. Owing squashed/flattened morphology by magnetic forces resulting close proximity near‐infrared (NIR) labels on pGOLD surface, ultrahigh NIR fluorescence enhancement ≈50–120‐fold...
Ionic hydrogels (PVA-PA-E/M hydrogels) with high adhesive strength, good environmental stability, excellent antibacterial properties, and conductivity. The hydrogel-based strain sensor exhibited low hysteresis linearity simultaneously.
We propose a Metal–Insulator–Metal structure consists of two surface plasmon polaritons (SPPs) and an H-shaped resonator. The reflectance spectrum is numerically simulated by the two-dimensional finite-difference time-domain method. results show that this can act as pressure sensor. To our knowledge, first proposal to utilize SPP resonator form size be small few hundred nanometers. nano-scale sensor opens wide field for potential applications in biological biomedical engineering.