A5037471658- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Algal biology and biofuel production
- Cancer-related molecular mechanisms research
- Photosynthetic Processes and Mechanisms
- RNA modifications and cancer
- Pregnancy-related medical research
- Ectopic Pregnancy Diagnosis and Management
- Estrogen and related hormone effects
- RNA Research and Splicing
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Differential Equations and Boundary Problems
- Ovarian cancer diagnosis and treatment
- Reproductive Health and Contraception
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Medical Research and Treatments
- Light effects on plants
- Dengue and Mosquito Control Research
Shanghai Jiao Tong University
2016-2025
International Peace Maternity & Child Health Hospital
2016-2025
Quzhou City People's Hospital
2020-2025
Xian Yang Central Hospital
2025
Inner Mongolia Medical University
2024
Shanghai Municipal People's Government
2019-2024
Renji Hospital
2011-2024
Nanjing Tech University
2024
Soochow University
2012-2024
Wuxi Ninth People's Hospital
2024
Endometriosis, a chronic disorder characterised by the presence of endometrial-like tissue outside uterus, is associated with iron overload and oxidative stress in lesion. Although it well established that can trigger ferroptosis, results previous studies on ferroptosis resistance endometriotic lesions are paradoxical. Here, we found some stromal cells cyst walls were contact fluid underwent ferroptosis. Surprisingly, endometrial cell triggered production angiogenic, inflammatory growth...
Solid pseudopapillary tumor of the pancreas (SPTP) is a low-grade malignant with favorable prognosis after surgery. Many previous studies have focused on clinical features or pathological biomarkers disease, but better understanding molecular mechanisms underlying SPTP may help guide future therapeutic strategies. Here, we used isobaric tags for relative and absolute quantitation (iTRAQ) technology integrated liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to identify...
Abstract Since most variants that impact polygenic disease phenotypes localize to non-coding genomic regions, understanding the consequences of regulatory element will advance human mechanisms. Here, we report systemic lupus erythematosus (SLE) risk variant rs2431697 as likely causal for SLE through disruption a element, modulating miR-146a expression. Using epigenomic analysis, genome-editing and 3D chromatin structure show tags cell-type dependent distal enhancer specific physically...
In recent years, the reproductive toxicity of new bisphenol analogs has garnered much interest, but it remains to be determined whether affect polycystic ovarian syndrome (PCOS). This study utilized data from a multicenter hospital-based case-control conducted in 2014–2016 examine association between endocrine-disrupting chemicals and infertility China. 321 PCOS cases 412 controls were included current analysis. We quantified seven urine samples, including A (BPA), AP (BPAP), AF (BPAF), B...
Abstract RNA acetylation is a universal post-transcriptional modification that occurs in various RNAs. Transfer (tRNA) found at position 34 (ac4C34) bacterial tRNAMet and 12 (ac4C12) eukaryotic tRNASer tRNALeu. The biochemical mechanism, structural basis functional significance of ac4C34 are well understood; however, despite being discovered the 1960s identification Kre33/NAT10 Tan1/THUMPD1 as modifying apparatuses, ac4C12 activity has never been reconstituted for nearly six decades. Here,...
Despite strong evidence that human genetic variants affect the expression of many key transcription factors involved in autoimmune diseases, establishing biological links between non-coding risk and gene targets they regulate remains a considerable challenge. Here, we combine genetic, epigenomic, CRISPR activation approaches to screen for functional IRF8 expression. We demonstrate locus containing rs2280381 is cell-type-specific enhancer spatially interacts with promoter. Further, mediates...
An Arabidopsis thaliana chlorophyll(ide) a oxygenase gene ( cao ), which is responsible for chlorophyll b synthesis from , was introduced and expressed in photosystem I-less strain of the cyanobacterium Synechocystis sp . PCC 6803. In this strain, most associated with II complex. line observations by Satoh et al. [Satoh, S., Ikeuchi, M., Mimuro, M. & Tanaka, A. (2001) J. Biol. Chem 276, 4293–4297], made but accounted less than 10% total chlorophyll. However, when lhcb encoding...
Abstract Transcriptional repressor Snail is a master regulator of epithelial–mesenchymal transition (EMT), yet the epigenetic mechanism governing to induce EMT not well understood. Here, we report that in pancreatic ductal adenocarcinoma (PDAC), elevated levels ubiquitin E3 ligase Ring1B and Snail, along with monoubiquitination H2A at K119 (H2AK119Ub1), are highly correlated poor survival. Mechanistic investigations identified as Snail-interacting protein showed carboxyl zinc fingers recruit...
Abstract Pancreatic cancer is a highly lethal malignancy with poor prognosis due to the lack of early symptoms and resultant late diagnosis. Thus, it extremely urgent establish simple effective method for diagnosis pancreatic cancer. Although some studies have provided positive evidence use exosomal surface protein glypican-1 (GPC1) as biomarker screening, its clinical application still controversial. Here, we systematically verified role GPC1 potential screening biomarker. First, bottleneck...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal common cancer because late diagnosis. tRNA-derived small RNAs (tsRNAs) are novel might serve as biomarkers for diagnosis and participate in diverse physiological pathological process. We investigated whether expression tsRNAs serum could be a noninvasive method early PDAC. Methods Blood sample PDAC patients healthy controls were collected from Ruijin Hospital, Shanghai, China. Tumor adjacent normal...
In recent years, perfluoroalkyl substances (PFASs), a family of fluorinated organic com pounds, have garnered much attention due to their reproductive and developmental toxicity in humans. Polycystic ovary syndrome (PCOS) is prevalent endocrine disease that affects women age significant contributor female infertility. A previous study suggested PFASs play possible role PCOS. We conducted clinical investigating the relationship between PCOS PFAS follicular fluid. total 73 infertile patients...
This prospective study aimed to determine whether patients with endometriosis are having different level of interlukin‐17 (IL‐17) in peritoneal fluid when compared without endometriosis. The minimal/mild had a significantly higher IL‐17 those moderate/severe or concentration was and infertility coexist. However, the did not correlate phase menstrual cycle Our suggested that might play an important role pathogenesis early endometriosis‐associated infertility.
BACKGROUNDAlthough nerve fibres are present in eutopic and ectopic endometrium, it is unclear whether they appear ovarian endometriotic lesions. We investigated the presence of lesions its correlation with clinical parameters women endometriosis.
Abstract The eutopic endometrium has been suggested to play a crucial role in the pathogenesis of adenomyosis. However, specific genes responsible for adenomyosis still remain be elucidated. We aim identify differentially expressed (DEGs) and molecular pathways/networks from patients provide new insight into disease mechanisms at transcriptome level. RNA sequencing (RNA‐Seq) was performed with 12 control groups. Differentially were validated by quantitative real‐time PCR (qPCR)...
Abstract Adenomyosis is associated with dysmenorrhea, infertility, and lesional fibrosis. The pathogenesis of adenomyosis still unclear. Plasminogen activator inhibitor 1 (PAI-1) plays important roles in pathological activities like tumor metastasis endometriosis. Our objective was to investigate the expression localization PAI-1 eutopic ectopic endometrium without adenomyosis. We also sought determine relationship between immunoreactivity severity dysmenorrhea extent fibrosis significantly...
Abstract Backgroud Laparoscopic adenomyomectomy combined with intraoperative placement of levonorgestrel-releasing intrauterine device (LNG-IUS) is a novel conservative surgical procedure for adenomyosis. Our study aimed to compare the efficacy surgery or without LNG-IUS treatment in Methods We retrospectively reviewed medical records adenomyosis patients who received laparoscopic from January 2014 April 2020, finally including 70 undergoing surgery-LNG-IUS as group A and 69 undegoing only...