A5100450767- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Sharing Economy and Platforms
- Oral microbiology and periodontitis research
- Circular RNAs in diseases
- Pharmacogenetics and Drug Metabolism
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Curcumin's Biomedical Applications
- Photodynamic Therapy Research Studies
- 2D Materials and Applications
- Genetic Associations and Epidemiology
- Biochemical Acid Research Studies
- Data-Driven Disease Surveillance
- Trace Elements in Health
- Public Health Policies and Education
- Surgical Sutures and Adhesives
- Redox biology and oxidative stress
- Sulfur Compounds in Biology
Shijiazhuang Tiedao University
2025
City University of Macau
2025
Shanghai Jiao Tong University
2013-2025
National Clinical Research Center for Digestive Diseases
2023-2025
Shanghai Ninth People's Hospital
2023-2025
Sichuan University
2008-2024
Institute of Semiconductors
2024
Chinese Academy of Sciences
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Triple-negative breast cancer is often aggressive and resistant to various therapies, especially corresponding targeted drugs. It shown that delivery of chemotherapeutic drugs tumor sites could enhance treatment outcome against triple-negative cancer. In this study, we exploited the active tumor-targeting capability macrophages by loading doxorubicin-carrying liposomes on their surfaces via biotin–avidin interactions. Compared with conventional liposomes, macrophage–liposome (MA-Lip) system...
Abstract Rheumatoid arthritis (RA) is a common chronic inflammatory disorder that usually affects joints. It was found roburic acid (RBA), an ingredient from anti-RA herb Gentiana macrophylla Pall., displayed strong anti-inflammatory activity. However, its medical application limited by hydrophobicity, lack of targeting capability and unclear functional mechanism. Here, we constructed pH responsive dual-target drug delivery system hitchhiking RBA (RBA-NPs) targeted both CD44 folate...
Though plastic nanoparticles have already raised much concern for their potential impact on health, our understanding of biological effects is still utterly limited. Here we demonstrate the first time that carboxyl-modified polystyrene (CPS) could effectively inhibit ferroptosis as a result reduced cellular ROS which was triggered by transcription factor EB (TFEB) nucleus translocation. In this process, CPS entered cells via macropinocytosis, then CPS-containing macropinosomes fused with...
Practice- and Policy-Oriented Abstract This study analyzes whether a ride-hailing platform should adopt closed business model, that is, serving riders only with platform-owned vehicles, or an open allowing private vehicles to utilize the provide services. Analytical results reveal model leads more service supply (supply-augmenting effect) lower price increase (price discrimination–hindering in surge period, both benefiting riders. It also reduces number of idle normal thus resulting...
Plants are sessile organisms, and they can not move away under abiotic or biotic stresses. Thus plants have evolved a set of genes that response to adverse environment modulate gene expression. In this study, we characterized functionally studied an ERF transcription factor from Artemisia annua, AaERF1, which plays important role in stress responses. The AaERF1 promoter had been cloned GUS staining results promoter-GUS transgenic A. annua showed is expressed ubiquitiously all organs. Several...
A hydrogel drug cargo based on 2D tungsten nitride nanosheets was fabricated.
Abstract Background Studies have indicated a potential relationship between gut microbiota and renal cell carcinoma. However, the causal various types of carcinoma, as well role inflammatory protein mediators, remains unclear. Methods This study aimed to identify microbiota, protein, cancer through large-scale genome-wide association (GWAS) utilizing pooled data. We employed Mendelian randomization (MR) investigate among these variables. Inverse variance weighting (IVW) was utilized primary...
ABSTRACT Residential mobility is a common phenomenon of tourism gentrification that has been extensively studied from social, economic, and political perspectives, leaving community psychology untouched. This study introduces theoretical model assesses the intention residents to relocate by examining their perceptions change relative deprivation—the comparison one's own or another's circumstances determine whether they are “better” “worse”. In order enhance representativeness, 313 valid...
A novel and efficient graphene-based gene delivery vector was prepared, the effect of changing PEI content on size, stability transfection efficiency were investigated.
Abstract Background Due to their porous structure and capability degrade under acidic conditions, CaCO 3 nanoparticles in vaterite form can be used as carriers effectively deliver drugs low-pH sites such tumors. The usually intravenous administration requires long-term phase colloidal stability for storage blood circulation. While passive accumulation tumors achieved via the enhanced permeation retention effect, active reactive groups on conjugate targeting molecules. Both requirements are...
Tissue adhesions could occur following surgeries, and severe tissue can lead to serious complications. Medical hydrogels be applied at surgical sites as a physical barrier prevent adhesion. For practical reasons, spreadable, degradable, self-healable gels are highly demanded. To meet these requirements, we carboxymethyl chitosan (CMCS) poloxamer-based generate low Poloxamer338 (P338) content displaying viscosity refrigerator temperature improved mechanical strength body temperature. Heparin,...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy, with high mortality rate unavailability of accurate therapies. However, its early prevention remains challenge. In the purview predictive, preventive, personalized medicine (PPPM), it paramount to identify novel powerful biomarkers. CISD2 crucial regulator iron homeostasis reactive oxygen species (ROS). Recent studies showed that NEET protein (NAF‐1) encoded by involved in regulating proliferation...