A5102345428- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Blood groups and transfusion
- Congenital heart defects research
- Angiogenesis and VEGF in Cancer
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Erythrocyte Function and Pathophysiology
- Zebrafish Biomedical Research Applications
- Forensic and Genetic Research
- Supply Chain and Inventory Management
- Cancer Risks and Factors
- Neonatal Health and Biochemistry
- Autopsy Techniques and Outcomes
- Healthcare Systems and Reforms
- Platelet Disorders and Treatments
- Cancer-related gene regulation
- Lipid metabolism and disorders
- Global Maternal and Child Health
- Nuts composition and effects
- Peroxisome Proliferator-Activated Receptors
- Advanced Decision-Making Techniques
- Cholesterol and Lipid Metabolism
- Growth Hormone and Insulin-like Growth Factors
Guiyang Medical University
2025
Beijing Red Cross Blood Center
2022
Center for Excellence in Molecular Cell Science
2014-2021
University of Chinese Academy of Sciences
2019-2021
Chinese Academy of Sciences
2014-2020
Shanghai Institutes for Biological Sciences
2014-2017
Guangzhou Blood Center
2017
Civil Aviation University of China
2015
Hebei University
2009-2010
Vascular growth and remodeling are dependent on the generation of new endothelial cells from stem involvement perivascular to maintain vessel integrity function. The existence cellular identity vascular (VESCs) remain unclear. pericytes in adult tissues thought arise recruitment differentiation mesenchymal progenitors during early development. In this study, we identified Protein C receptor-expressing (Procr+) as VESCs multiple tissues. Procr+ exhibit robust clonogenicity culture, high...
Signals from the niche play pivotal roles in regulating adult stem cell self-renewal. Previous studies indicated that steroid hormones can expand mammary cells (MaSCs) vivo. However, facilitating local factors directly contribute to MaSC expansion remain unclear. Here we identify R-spondin1 (Rspo1) as a novel hormonal mediator gland. Pregnancy and treatment up-regulate Rspo1 expression. cooperates with another mediator, Wnt4, promote self-renewal through Wnt/β-catenin signaling. Knockdown of...
The post-translational modification of proteins, including glycosylation, differs between normal and tumor cells. UDP-N-acetyl-D-galactosamine polypeptide N-acetylgalactosaminyltransferases (GalNAc-Tases) family enzymes regulates the initial steps mucin O-glycosylation is responsible for altered glycosylation state observed in cancer Recently it was found that GalNAc-T14 mRNA heterogeneously expressed breast carcinomas compared to tissue, however expression profile protein tissue still...
Endothelial and fibroblast niches are crucial for epithelial organs. How these heterotypic cells interact is of great interest. In this study, we reveal an axis signaling in which fibroblasts relay Wnt signals from the endothelial niche to organize patterning. We generate Axin2-membrane GFP (mGFP) reporter mouse observe robust Wnt/β-catenin activities surrounding mammary epithelium. To enable cell-type-specific gene manipulation vitro, establish organoid system via coculture (ECs),...
R-spondin1 (Rspo1) has been featured as a Wnt agonist, serving potent niche factor for stem cells in many tissues. Here we unveil novel role of Rspo1 promoting estrogen receptor alpha (Esr1) expression, hence regulating the output steroid hormone signaling mouse mammary gland. This action relies on Lgr4 and intracellular cAMP-PKA signaling, yet is independent Wnt/β-catenin signaling. These mechanisms were reinforced by genetic evidence. Luminal cells-specific knockout results decreased Esr1...
ABSTRACT HLA‐DQB1*04:01:09 has one nucleotide substitution compared to HLA‐DQB1*04:01:01:03 at position 759 in exon 4.
Abstract Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth. However, a significant portion human cancer, how signaling is perturbed remains unknown. To answer this question, we performed genome-wide screening genes that affect in Drosophila cross-referenced hit with cancer genome. In our screen, Prosap was identified as novel regulator potently affects tissue growth. Interestingly, mammalian homolog , SHANK2, most...
Shanghai is one of the pioneers proposing family doctor contract service (FDCS). However, there no quantitative research focusing on experience from a demand-side perspective. This study investigated chronic patients' relative preferences for FDCS using discrete choice experiment method. A face-to-face (DCE) was performed to elicit preference with 300 samples. Attributes and levels were extracted literature review focus group consultation patients. Seven attributes, follow-up frequency,...
Endothelial cells (ECs) are the fundamental building blocks of vascular architecture and mediate growth remodeling to ensure proper vessel development homeostasis. However, studies on endothelial lineage hierarchy remain elusive due lack tools gain access as well directly evaluate their behavior in vivo. To address this shortcoming, a new tissue model study angiogenesis using mammary fat pad has been developed. The gland develops mostly postnatal stages, including puberty pregnancy, during...
The FUT3 gene encodes α(1,3/1,4)-fucosyltransferase, which is a crucial enzyme in the synthesis of Lewis antigens. variants show race-specific differences. In this study, we conducted systematic sequence analysis coding sequence. objective was to explore genetic variations within Han population Northern China.
Helicobacter pylori infection is a significant pathogen in gastrointestinal diseases. Previous studies have identified single-nucleotide polymorphisms (SNPs) are factors associated with H. infection. Notably, Le
Endothelial cells (ECs) are the fundamental building blocks of vascular architecture and mediate growth remodeling to ensure proper vessel development homeostasis. However, studies on endothelial lineage hierarchy remain elusive due lack tools gain access as well directly evaluate their behavior in vivo. To address this shortcoming, a new tissue model study angiogenesis using mammary fat pad has been developed. The gland develops mostly postnatal stages, including puberty pregnancy, during...
In order to reduce the security of time, this paper introduced action analysis, guided by economic principle motion principle, Uses IEMS video analysis software, in process analysis.By removing invalid move, improve effective dynamic element, obtain a new video.Without any increase funds, sites and staff under premise provide considerable work personnel, efficiency security.
Objective To identify platelet allo-antibodies and auto-antibodies by simultaneous analysis of specific antibodies (SASPA) evanescent biosensor technology (EVA). Method Sera from 94 patients with HPA-1a, HPA-5b, HLA-I antibody were collected.The glycoprotein (GP)-specific complexes prepared.SASPA EVA performed to detect the antibodies.The mean fluorescence intensity (MFI) Slope values compared analyzed. Results For detection SASPA, sensitivity was 74.1%, 86.9%, 86.9% 40.9%,...
Objective To investigate the identification and characteristics of anti-HI compound antibody with wide thermal amplitude. Methods In March 2017, one pregnant woman positive irregular who identified specificity in Blood Group Research Department Dalian Center was selected as object this study. The 27 years old, AB, RhD blood group, 37 weeks pregnant. In past, had a surviving child through caesarean section, no history transfusion. A volume 5 mL peripheral collected from women her...