A5062889116- Cancer Immunotherapy and Biomarkers
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- CAR-T cell therapy research
- Rheumatoid Arthritis Research and Therapies
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- T-cell and B-cell Immunology
- Nicotinic Acetylcholine Receptors Study
- Smoking Behavior and Cessation
- Behavioral Health and Interventions
- Dementia and Cognitive Impairment Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cytomegalovirus and herpesvirus research
- Medical and Health Sciences Research
- Alzheimer's disease research and treatments
- IL-33, ST2, and ILC Pathways
- Neutropenia and Cancer Infections
- Immune cells in cancer
- Sarcoidosis and Beryllium Toxicity Research
- Obsessive-Compulsive Spectrum Disorders
- Genetic Neurodegenerative Diseases
- Circular RNAs in diseases
- Salivary Gland Disorders and Functions
- Melanoma and MAPK Pathways
University of Oxford
2018-2025
First Affiliated Hospital of GuangXi Medical University
2025
MRC Weatherall Institute of Molecular Medicine
2022-2025
Air Force Medical University
2025
Guangxi Medical University
2025
Oxford University Hospitals NHS Trust
2023-2024
Huashan Hospital
2024
John Radcliffe Hospital
2018-2021
Churchill Hospital
2019-2021
University of Cambridge
2015-2020
Abstract Treatment with immune checkpoint blockade (ICB) frequently triggers immune-related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving ICB for melanoma, we observed increased severe irAE risk in minor allele carriers of rs16906115, intronic to IL7 . We found that rs16906115 forms a B cell-specific expression quantitative trait locus (eQTL) patients. Patients carrying the demonstrate pre-treatment cell expression, which independently associates risk,...
To evaluate TNF-α inhibitor (TNFi) persistence when used as first- or second-line biologic therapy for the management of PsA, and to determine baseline clinical laboratory parameters associated with TNFi persistence.A retrospective single-centre cohort study was performed on all patients PsA initiated between 2003 2015. Demographic, characteristics were compared persistence, using Kaplan-Meier survival Cox proportional hazards models.One hundred eighty-eight prescribed first-line over a...
Abstract Background Immune checkpoint blockers (ICBs) activate CD8 + T cells, eliciting both anti-cancer activity and immune-related adverse events (irAEs). The relationship of irAEs with baseline parameters clinical outcome is unclear. Methods Retrospective evaluation on survival was performed across primary ( N = 144) secondary 211) independent cohorts patients metastatic melanoma receiving single agent (pembrolizumab/nivolumab—sICB) or combination (nivolumab ipilimumab—cICB) blockade. RNA...
We describe three cases of critical acute myositis with myocarditis occurring within 22 days each other at a single institution, all 1 month receiving the initial cycle anti-PD-1 drug pembrolizumab. Analysis T cell receptor repertoires from peripheral blood and tissues revealed high degree clonal expansion public clones between cases, several expanded skeletal muscle putatively recognizing viral epitopes. All patients had recently received COVID-19 mRNA booster vaccine prior to treatment...
Abstract Cytomegalovirus (CMV) is a globally endemic latent herpes virus that profoundly impacts T cell immunity. We investigated the oncological consequences of CMV infection across 341 prospectively recruited patients receiving immune checkpoint blockade (ICB) for melanoma. + with metastatic melanoma (MM) have higher lymphocyte counts, reduced neutrophil to ratio and divergent CD8 gene expression. Combination anti-CTLA-4/anti-PD-1 ICB, but not single-agent anti-PD-1 induces cytotoxicity...
Ferroptosis, an iron-dependent regulated cell death pathway, shares several features of Parkinson's disease (PD) physiopathology, and efficient neuroprotective therapies are required to prevent DAergic neuron initiated by ferroptosis. Electroacupuncture (EA), a treasure Traditional Chinese Medicine, exerted therapeutic effects against PD avoid the side dopamine (DA)-based therapies. However, its underlying mechanisms still need be fully understood. MPTP-induced mice were treated with EA...
"Successful tocilizumab desensitization in an adult with juvenile idiopathic arthritis." Scandinavian Journal of Rheumatology, 45(1), pp. 75–76
Objective. Patient self-report scales are invaluable in psoriatic arthritis (PsA), as they allow physicians to rapidly assess patient perspectives of disease activity. We aimed the agreement visual analog scale (VAS), a 100-mm horizontal line, and numerical rating (NRS), 21-point ranging from 0 10 increments 0.5, patients with PsA. Methods. Data were collected prospectively across 3 UK hospital trusts 2018 2019. All completed VAS NRS for pain, arthritis, skin psoriasis (PsO), global A subset...
Abstract Rationale Checking is a functional behaviour that provides information to guide behaviour. However, in obsessive-compulsive disorder (OCD), checking may escalate dysfunctional levels. The processes underpinning the transition from are unclear but be associated with individual differences support development of maladaptive We examined one such predisposition, sign-tracking pavlovian conditioned stimulus, which we previously found checking. How interacts another treatment emerging...
<h3>Introduction</h3> Checkpoint inhibitor immunotherapy use has increased significantly over recent years with licensing for more indications. Whilst immunotherapy-related colitis and hepatitis are well-recognised adverse events, gastritis (irG) is less well-described can present a diagnostic challenge. <h3>Methods</h3> A retrospective review of the oncology/electronic patient records was done to identify irG patients demographics, cancer type, investigations treatments recorded....
Ye, Weiyu BA; Fifield, Maeve C. MB, BS, MA, (Cantab), MRCP; Östör, Andrew J. K. FRACP, FRCP, FRCP (Edin) Author Information
Abstract Background The visual analogue scale (VAS), a 100mm horizontal line, is commonly used for many outcomes including pain in psoriatic arthritis (PsA). However, it can be susceptible to measurement error. numerical rating (NRS), 21-point scale, overcomes these limitations, however, not yet validated PsA. We aimed assess the agreement and reliability of VAS NRS scales Methods Data was collected prospectively across three UK hospital trusts from 2018-2019. All patients completed pain,...
Abstract We describe three cases of critical acute myositis with myocarditis occurring within 22 days each other at a single institution, all one month receiving the initial cycle anti-PD-1 drug Pembrolizumab. Analysis T cell receptor repertoires from peripheral blood and tissues revealed high degree clonal expansion public clones between cases, several expanded skeletal muscle putatively recognising viral epitopes. All patients had recently received COVID-19 mRNA booster vaccine prior to...
ABSTRACT Clinical responses to immune checkpoint blockade (ICB) for metastatic melanoma (MM) are variable, with patients frequently developing related adverse events (irAEs). The role played by myeloid populations in modulating ICB remains poorly defined. We explored the effect of MM and response across a cohort (n=116) healthy donors (n=45) using bulk single cell RNA-seq, flow cytometry. Monocytes from exhibit highly dysregulated baseline transcriptional profiles, whilst treatment elicits...
<h3>Background:</h3> Primary Sjögren's syndrome (pSS) is a heterogeneous systemic autoimmune disease marked with varied clinical manifestations and diversified treatment response, potentially due to different pathogeneses among patients. <h3>Objectives:</h3> Our study aimed clarify the etiology molecular variation of target organ, salivary glands (SGs), in pSS by stratifying them into distinguishable subgroups, which could inform choices pSS. <h3>Methods:</h3> Large-scale transcriptomic...
Summary Paragraph The relationship between chronic viral infection and cancer response to immune checkpoint blockade (ICB) is poorly understood. Cytomegalovirus (CMV) globally endemic causes severe disease in the immunocompromised. In immunocompetent individuals clinical effects of CMV are an area active investigation. Here, analysis 396 patients receiving ICB for cancer, we investigate oncological immunological consequences seropositivity. We find that with leads profound skewing CD8 + T...